Product Details of 14660-52-7In 2021 ,《Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell lines》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry. The article was written by Nencetti, Susanna; Cuffaro, Doretta; Nuti, Elisa; Ciccone, Lidia; Rossello, Armando; Fabbi, Marina; Ballante, Flavio; Ortore, Gabriella; Carbotti, Grazia; Campelli, Francesco; Banti, Irene; Gangemi, Rosaria; Marshall, Garland R.; Orlandini, Elisabetta. The article contains the following contents:
Uveal melanoma (UM) represents an aggressive type of cancer and currently, there is no effective treatment for this metastatic disease. In the last years, histone deacetylase inhibitors (HDACIs) have been studied as a possible therapeutic treatment for UM, alone or in association with other chemotherapeutic agents. Here we synthesized a series of new HDACIs based on the SAHA scaffold bearing an (arylidene)aminoxy moiety. Their HDAC inhibitory activity was evaluated on isolated human HDAC1, 3, 6, and 8 by fluorometric assay and their binding mode in the catalytic site of HDACs was studied by mol. docking. The most promising hit was the quinoline derivative , a nanomolar inhibitor of HDAC6, which exhibited a good antiproliferative effect on UM cell lines at micromolar concentration and a capability to modify the mRNA levels of HDAC target genes similar to that of SAHA. The experimental part of the paper was very detailed, including the reaction process of Ethyl 5-bromovalerate(cas: 14660-52-7Product Details of 14660-52-7)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Product Details of 14660-52-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary