In 2022,Varakala, Saiprasad Dasugari; Reshma, Rudraraju Srilakshmi; Schnell, Robert; Dharmarajan, Sriram published an article in European Journal of Medicinal Chemistry. The title of the article was 《Lead derivatization of ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate and 5-bromo-2-(thiophene-2-carboxamido) benzoic acid as FabG inhibitors targeting ESKAPE pathogens》.Reference of 3-Bromo-2-methylbenzoic acid The author mentioned the following in the article:
Our previous studies on FabG have identified two compounds 5-bromo-2-(thiophene-2-carboxamido) benzoic acid (A) and Et 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate(B) as best hits with allosteric mode of inhibition. FabG is an integral part of bacterial fatty acid biosynthetic system FAS II shown to be an essential gene in most ESKAPE Pathogens. The current work is focussed on lead expansion of these two hit mols. which ended up with forty-three analogs (twenty-nine analogs from lead compound A and fourteen compounds from lead compound B). The enzyme inhibition studies revealed that compound I (effective against EcFabG, AbFabG, StFabG, MtFabG1) and II (inhibiting EcFabG and StFabG) had potency of broad-spectrum inhibition on FabG panel. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Reference of 3-Bromo-2-methylbenzoic acid)
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Reference of 3-Bromo-2-methylbenzoic acid Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary