In 2022,Henriques, Dina Schwarz G.; Rojo-Wiechel, Elena; Klare, Sven; Mika, Regine; Hothker, Sebastian; Schacht, Jonathan H.; Schmickler, Niklas; Gansauer, Andreas published an article in Angewandte Chemie, International Edition. The title of the article was 《Titanocene(III)-Catalyzed Precision Deuteration of Epoxides》.Application In Synthesis of Ethyltriphenylphosphonium bromide The author mentioned the following in the article:
Authors describe a titanocene(III)-catalyzed deuterosilylation of epoxides that provides β-deuterated anti-Markovnikov alcs. with excellent D-incorporation, in high yield, and often excellent diastereoselectivity after desilylation. The key to the success of the reaction is a novel activation method of Cp2TiCl2 and (tBuC5H4)2TiCl2 with BnMgBr and PhSiD3 to provide [(RC5H4)2Ti(III)D] without isotope scrambling. It was developed after discovering an off-cycle scrambling with the previously described method. Precision deuteration can be applied to the synthesis of drug precursors and highlights the power of combining radical chem. with organometallic catalysis. In the experiment, the researchers used many compounds, for example, Ethyltriphenylphosphonium bromide(cas: 1530-32-1Application In Synthesis of Ethyltriphenylphosphonium bromide)
Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Application In Synthesis of Ethyltriphenylphosphonium bromide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary