Li, Zhen; Huang, Meirong; Zhang, Xinhao; Chen, Jiean; Huang, Yong published the artcile< N-Heterocyclic Carbene-Catalyzed Four-Component Reaction: Chemoselective Cradical-Cradical Relay Coupling Involving the Homoenolate Intermediate>, Application In Synthesis of 3893-18-3, the main research area is beta tertiary gamma quaternary carboxylic acid chemoselective preparation; enal olefin nucleophile Togni reagent multicomponent relay coupling organocatalyst.
An organocatalytic four-component relay radical coupling to access a broad spectrum of β-tertiary-γ-quaternary carboxylic acid derivatives I [R = Ph, 4-MeC6H4, 2-thienyl, etc.; R1 = H, Ph, 4-BrC6H4, etc.; R2 = Et, Ph, 2-furyl, etc.; R3 = OMe, OEt, HNCH2C6H5, etc.] using simple reagents was reported. This strategy was complementary to the classical closed-shell synthetic approaches and was particularly effective in introducing a quaternary carbon substituent at β-carbon. Mechanistically, relay radical coupling involving N-heterocyclic carbene-derived homoenolates was challenging due to issues associated with site-selectivity and catalyst turnover. In this report, demonstrated high site control using a triazolium N-heterocyclic carbene catalyst and a transient acyl trapping strategy to prepare diversified carboxylic acid derivatives in a single pot.
ACS Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application In Synthesis of 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary