Gotoh, Hiroaki; Ishikawa, Hayato; Hayashi, Yujiro published the artcile< Diphenylprolinol Silyl Ether as Catalyst of an Asymmetric, Catalytic, and Direct Michael Reaction of Nitroalkanes with α,β-Unsaturated Aldehydes>, SDS of cas: 3893-18-3, the main research area is silyl ether stereoselective Michael addition catalyst nitroalkane unsaturated aldehyde.
A catalytic enantioselective direct conjugate addition of nitroalkanes to α,β-unsaturated aldehydes using diphenylprolinol silyl ether as an organic catalyst has been developed. Using this methodol. as a key step, short syntheses of therapeutically useful compounds have also been accomplished. For example, the reaction of 4-chlorocinnamaldehyde with nitromethane using (2S)-2-[diphenyl[(trimethylsilyl)oxy]methyl]pyrrolidine as catalyst gave (-)-(βS)-4-chloro-β-(nitromethyl)benzenepropanal. The latter was converted into (βS)-4-chloro-β-(nitromethyl)benzenepropanoic acid, which is a precursor for (S)-baclofen.
Organic Letters published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (nitro). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary