Gao, Limei; Shi, Ruijie; Tian, Yuting; Luo, Xi; Zheng, Yongsheng; Wang, Qiang published the artcile< Synthesis of Pyrazoles through [3+2] Cyclization of Nitrile Imines with Cinnamaldehydes Followed by Air Oxidation>, SDS of cas: 3893-18-3, the main research area is pyrazole preparation green chem regioselective; nitrile imine cinnamyl aldehyde cycloaddition oxidation.
An unprecedented [3+2] cycloaddition reaction of in situ generated nitrile imines with cinnamyl aldehydes followed by air oxidation has been successfully developed under mild conditions, providing an efficient approach to multisubstituted pyrazoles (up to 88% yield). Preliminary mechanistic investigation implies that the final product is generated through oxidation in the presence of air. The prominent features of this reaction include mild conditions, simple operation and gram-scale synthesis.
ChemistrySelect published new progress about [3+2] Cycloaddition reaction (regioselective). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary