Yu, Bangkui; Zou, Suchen; Huang, Hanmin published the artcile< Palladium-Catalyzed Ring-Closing Reaction for the Synthesis of Saturated N-Heterocycles with Aminodienes and N,O-Acetals>, Application of C7H8BrN, the main research area is saturated heterocycle preparation; aminodiene acetal palladium catalyst ring closing reaction.
An efficient palladium-catalyzed ring-closing reaction of aminodienes e.g., (E)-N-(2-(benzylamino)ethyl)-4-methyl-N-(penta-2,4-dien-1-yl)benzenesulfonamide with N,O-acetals RN(R1)CH2OCH3 [R = n-Bu, Bn, (4-bromophenyl)methyl, etc.; R1 = n-Bu, Bn, (4-bromophenyl)methyl, etc.; RR1 = -(CH2)2O(CH2)2-] for the synthesis of saturated N-heterocycles e.g., (E)-N,N-dibenzyl-3-(1-benzyl-4-tosyl-1,4-diazepan-6-yl)prop-2-en-1-amine is described. The reaction is consistently operated at room temperature and tolerates a wide range of functional groups with volatile MeOH as the sole byproduct. This method provides rapid and practical access to a broad range of saturated N-heterocycles e.g., (E)-N,N-dibenzyl-3-(1-benzyl-4-tosyl-1,4-diazepan-6-yl)prop-2-en-1-amine with diverse structural backbones that are useful building blocks in natural product synthesis and drug discovery.
Journal of Organic Chemistry published new progress about Acetals Role: RCT (Reactant), RACT (Reactant or Reagent) (N, O). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application of C7H8BrN.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary