Fier, Patrick S.; Maloney, Kevin M. published an article on January 30 ,2019. The article was titled 《NHC-Catalyzed Deamination of Primary Sulfonamides: A Platform for Late-Stage Functionalization》, and you may find the article in Journal of the American Chemical Society.Recommanded Product: 25195-52-2 The information in the text is summarized as follows:
Primary alkyl and aryl sulfonamides underwent chemoselective deamination reactions with benzaldehyde and K2CO3 in the presence of a pyrrolotriazolium chloride via N-benzylidenesulfonamides to yield sulfinate salts; the sulfinates were converted in situ to Me and aryl sulfones, sulfonic acids, and sulfonamides. Reaction of the sulfinates with MeI in DMF yielded Me sulfones, while oxidation with H2O2 in the presence of tungstic acid yielded sulfonic acids. Reaction of the sulfinate generated from celecoxib with 15NH4OH yielded the corresponding 15N-labeled sulfonamide; coupling reactions of the celecoxib-derived sulfinate with iodobenzene and a chloropyridine yielded aryl sulfones, while desulfonative coupling with Ph triflate yielded a biphenylpyrazole. The method tolerated nearly all common functional groups, including primary amines, and was used for the late-stage derivatization of several complex pharmaceutical compounds In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-2-((methylsulfonyl)methyl)benzene(cas: 25195-52-2Recommanded Product: 25195-52-2)
1-Bromo-2-((methylsulfonyl)methyl)benzene(cas: 25195-52-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Recommanded Product: 25195-52-2 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary