In 2018,Angewandte Chemie, International Edition included an article by Garg, Neeraj; Conway, Louis P.; Ballet, Caroline; Correia, Mario S. P.; Olsson, Frida K. S.; Vujasinovic, Miroslav; Loehr, J.-Matthias; Globisch, Daniel. Electric Literature of C7H4BrNO4. The article was titled 《Chemoselective Probe Containing a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism》. The information in the text is summarized as follows:
While metabolites derived from gut microbiota metabolism have been linked to disease development in the human host, the chem. tools required for their detailed anal. and the discovery of biomarkers are limited. A unique and multifunctional chem. probe for mass spectrometric anal., which contains p-nitrocinnamyloxycarbonyl as a new bioorthogonal cleavage site has been designed and synthesized. Coupled to magnetic beads, this chem. probe allows for straightforward extraction of metabolites from human samples and release under mild conditions. This isolation from the sample matrix results in significantly reduced ion suppression, an increased mass spectrometric sensitivity, and facilitates the detection of metabolites in femtomole quantities. The chemoselective probe was applied to the anal. of human fecal samples, resulting in the discovery of four metabolites previously unreported in this sample type and confirmation of the presence of medically relevant gut microbiota-derived metabolites. In addition to this study using 3-Bromo-2-nitrobenzoic acid, there are many other studies that have used 3-Bromo-2-nitrobenzoic acid(cas: 116529-61-4Electric Literature of C7H4BrNO4) was used in this study.
3-Bromo-2-nitrobenzoic acid(cas: 116529-61-4) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Electric Literature of C7H4BrNO4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary