Ling, Johanne; Bruneau-Voisine, Antoine; Journot, Guillaume; Evano, Gwilherm published the artcile< Copper-Catalyzed Carbonylative Cross-Coupling of Alkyl Iodides and Amines>, SDS of cas: 3959-07-7, the main research area is amide preparation; alkyl iodide amine carbon monoxide carbonylative cross coupling copper; amides; carbon monoxide; carbonylation; copper catalysis; cross-coupling.
A general copper-catalyzed carbonylative cross-coupling between amines and alkyl iodides was reported to form amides RC(O)NR1R2 [R = Cy, i-Pr, CH(Et)2, etc.; R1 = H, Me, R2 = n-hexyl, CH2Bn, t-Bu, etc.]. Using a simple combination of catalytic amounts of copper(I) chloride and N,N,N’;N””,N””-pentamethyldiethylenetriamine in the presence of sodium hydroxide under carbon monoxide pressure, a broad range of alkyl iodides and amines can be efficiently coupled to the corresponding amides that are obtained in good to excellent yields. Notable features of this process were the first one relying on a base metal catalyst, includeed the availability and low cost of the catalytic system, its successful use with primary, secondary, tertiary alkyl iodides and all classes of amines with no or limited competing nucleophilic substitution without CO incorporation as well as its efficiency with complex alkyl iodides and amines. Mechanistic studies demonstrated that a radical pathway is operative and the key role of CO.
Chemistry – A European Journal published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary