Related Products of 22385-77-9,Some common heterocyclic compound, 22385-77-9, name is 1-Bromo-3,5-di-tert-butylbenzene, molecular formula is C14H21Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 1-bromo-3,5-di-tert-butylbenzene (3.380 g, 12.55 mmol, 3 equiv) in THF (25mL) was added dropwise under stirring to magnesium turnings (0.366 g, 15.05 mmol, 3.2equiv), activated with iodine (?0.1 mg). The reaction was stirred for 4 h under reflux, thencooled to ambient temperature and the unreacted Mg was filtered off. The Grignard solutionwas added dropwise to a solution of BiCl3 (1.312 g, 4.16 mmol, 1 equiv) in THF (20 mL) at0 C, and the reaction mixture was stirred overnight at ambient temperature. The solvent wasremoved under vacuum and the green residue was extracted with n-pentane (3 ¡Á 20 mL). After the removal of the solvent, 4 was isolated a colorless solid. Yield: 2.362 g (73percent basedon BiCl3). Single crystals suitable for X-ray analyses were grown from CH2Cl2 solution.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3,5-di-tert-butylbenzene, its application will become more common.
Reference:
Article; Preda, Ana-Maria; Krasowska, Ma?gorzata; Wrobel, Lydia; Kitschke, Philipp; Andrews, Phil C.; MacLellan, Jonathan G.; Mertens, Lutz; Korb, Marcus; Rueffer, Tobias; Lang, Heinrich; Auer, Alexander A.; Mehring, Michael; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 2125 – 2145;,
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