《Phage-Guided Targeting, Discriminative Imaging, and Synergistic Killing of Bacteria by AIE Bioconjugates》 was published in Journal of the American Chemical Society in 2020. These research results belong to He, Xuewen; Yang, Yujun; Guo, Yongcan; Lu, Shuguang; Du, Yao; Li, Jun-Jie; Zhang, Xuepeng; Leung, Nelson L. C.; Zhao, Zheng; Niu, Guangle; Yang, Shuangshuang; Weng, Zhi; Kwok, Ryan T. K.; Lam, Jacky W. Y.; Xie, Guoming; Tang, Ben Zhong. Reference of 4-Bromobutanoic acid The article mentions the following:
New agents with particular specificity toward targeted bacteria and superefficacy in antibacterial activity are urgently needed in facing the crisis of worldwide antibiotic resistance. Herein, a novel strategy by equipping bacteriophage (PAP) with photodynamic inactivation (PDI)-active AIEgens (luminogens with aggregation-induced emission property) was presented to generate a type of AIE-PAP bioconjugate with superior capability for both targeted imaging and synergistic killing of certain species of bacteria. The targeting ability inherited from the bacteriophage enabled the bioconjugates to specifically recognize the host bacteria with preserved infection activity of phage itself. Meanwhile, the AIE characteristic empowered them a monitoring functionality, and the real-time tracking of their interactions with targets was therefore realized via convenient fluorescence imaging. More importantly, the PDI-active AIEgens could serve as powerful in situ photosensitizers producing high-efficiency reactive oxygen species (ROS) under white light irradiation As a result, selective targeting and synergistic killing of both antibiotic-sensitive and multi-drug-resistant (MDR) bacteria were successfully achieved in in vitro and in vivo antibacterial tests with excellent biocompatibility. This novel AIE-phage integrated strategy would diversify the existing pool of antibacterial agents and inspire the development of promising drug candidates in the future. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Reference of 4-Bromobutanoic acid)
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Reference of 4-Bromobutanoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary