《Palladium Catalyzed C-O Coupling of Amino Alcohols for the Synthesis of Aryl Ethers》 was written by Mikus, Malte S.; Sanchez, Carina; Fridrich, Cary; Larrow, Jay F.. Application of 7073-94-1 And the article was included in Advanced Synthesis & Catalysis in 2020. The article conveys some information:
Amine containing aryl ethers are common pharmacophore motifs that continue to emerge from drug discovery efforts. As amino alcs. are readily available building blocks, practical methodologies for incorporating them into more complex structures are highly desirable. We report our efforts to explore the application of Pd-catalyzed C-O coupling methods to the arylation of 1,2- and 1,3-amino alcs. [e.g., 1-bromo-4-(trifluoromethyl)benzene + amino alc. I → II (82%, 68% isolated)]. We established general and reliable conditions, under which we explored the scope and limitations of the transformation. The insights gained have been valuable in employing this methodol. within a fast-moving drug discovery environment, which we anticipate will be of general interest to the synthesis and catalysis communities. After reading the article, we found that the author used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Application of 7073-94-1)
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Application of 7073-94-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary