Kumar, Gautam; Bhattacharya, Debkanta; Chatterjee, Indranil published an article in 2022. The article was titled 《Lewis Acid-Assisted Transition Metal-Free Aminocyanation of Alkynes with Arylamines and N-Cyanosuccinimide》, and you may find the article in Advanced Synthesis & Catalysis.Category: bromides-buliding-blocks The information in the text is summarized as follows:
A transition-metal-free aminocyanation of aryl alkynes has been achieved using indium tribromide, InBr3 or B(C6F5)3 as a Lewis acid. This aminocyanation protocol features with non-toxic cyanide source, a good substrate scope and potentially valuable aminocyanation products. Mechanistic studies reveal the complex formation between Lewis acid and alkyne to produce in situ alkyne nitrile as a key intermediate. Further hydroamination of alkyne nitrile with arylamines affords the E-selective (E:Z = 70:30 to 90:10) β-aminoacrylonitrile derivatives The experimental process involved the reaction of Indium(III) bromide(cas: 13465-09-3Category: bromides-buliding-blocks)
Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary