Navarro, Gemma; Gonzalez, Angel; Sanchez-Morales, Adria; Casajuana-Martin, Nil; Gomez-Ventura, Marc; Cordomi, Arnau; Busque, Felix; Alibes, Ramon; Pardo, Leonardo; Franco, Rafael published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Design of Negative and Positive Allosteric Modulators of the Cannabinoid CB2 Receptor Derived from the Natural Product Cannabidiol》.COA of Formula: C20H20BrP The article contains the following contents:
Cannabidiol (CBD), the second most abundant of the active compounds found in the Cannabis sativa plant, is of increasing interest because it is approved for human use and is neither euphorizing nor addictive. Here, we design and synthesize novel compounds taking into account that CBD is both a partial agonist, when it binds to the orthosteric site, and a neg. allosteric modulator, when it binds to the allosteric site of the cannabinoid CB2 receptor. Mol. dynamic simulations and site-directed mutagenesis studies have identified the allosteric site near the receptor entrance. This knowledge has permitted to perform structure-guided design of neg. and pos. allosteric modulators of the CB2 receptor with potential therapeutic utility. The experimental part of the paper was very detailed, including the reaction process of Ethyltriphenylphosphonium bromide(cas: 1530-32-1COA of Formula: C20H20BrP)
Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.COA of Formula: C20H20BrP
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary