Related Products of 21524-34-5,Some common heterocyclic compound, 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, molecular formula is C15H23Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reactor thoroughly dried and purged with nitrogen was 300mL, 2-bromo-1,3,5-triisopropyl benzene 12.0g (42.4mmol), (2- methoxy-5-methylphenylboronic acid) 14.1g (85.0mmol), tripotassium phosphate (K3PO4) 27.0g (127mmol), Tris(dibenzylideneacetone)dipalladium(0) (chloroform adduct), 0.44g (0.42mmol), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl 0.35g (0.85mmol), was charged with toluene 100mL, and the mixture was stirred for 17 hours at 100C. The reaction solution was cooled to room temperature and filtered through celite. When the resultant residue by distilling off the filtrate purified by silica gel column chromatography, the desired product shown by the following formula (11) (hereinafter Compound (11) hereinafter) is 5.61 g (41% yield) obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-1,3,5-triisopropylbenzene, its application will become more common.
Reference:
Patent; MITSUI CHEMICALS INCORPORATED; KONDO, MASATAKA; UEHARA, NAOKI; MICHIGAMI, KENJI; ISHII, SEIICHI; TANAKA, KENICHI; (154 pag.)JP2015/193612; (2015); A;,
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