The author of 《Synthesis of difluoroalkylated 2-azaspiro[4.5]decane derivatives via copper-catalyzed difluoroalkylation/dearomatization of N-benzylacrylamides》 were Li, Chengwen; Zhao, Yilin; Zhou, Jiaxin; Wang, Xue; Hou, Jingli; Song, Yuguang; Liu, Wenjuan; Han, Guifang. And the article was published in Organic & Biomolecular Chemistry in 2020. Formula: C4H6BrFO2 The author mentioned the following in the article:
An efficient method for the synthesis of difluoroalkylated 2-azaspiro[4.5]decanes I [R1 = H, 7-OMe, 7-F, etc.; R2 = iPr, tBu, adamantan-1-yl; R3 = H, Me; R4 = EtO2C, Et2NCO, 1-pyrrolidinylcarbonyl, 1-piperidinylcarbonyl, 2,3-dihydro-1-indolylcarbonyl] via copper-catalyzed difluoroalkylation of N-benzylacrylamides with halo- fluoroacetate/difluoroacetate was established. The reaction experienced a tandem radical addition and dearomatizing cyclization process. In addition, the resultant products could be smoothly converted into a difluoroalkylated quinolinone and saturated spirocyclohexanone scaffold. The experimental part of the paper was very detailed, including the reaction process of Ethylbromofluoroacetate(cas: 401-55-8Formula: C4H6BrFO2)
Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Formula: C4H6BrFO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary