Application of 14660-52-7In 2020 ,《Multitarget Compounds for Bipolar Disorder: From Rational Design to Preliminary Pharmacokinetic Evaluation》 appeared in ChemMedChem. The author of the article were Di Martino, Rita Maria Concetta; Bottegoni, Giovanni; Seghetti, Francesca; Russo, Debora; Penna, Ilaria; De Simone, Alessio; Ottonello, Giuliana; Mandrup Bertozzi, Sine; Armirotti, Andrea; Bandiera, Tiziano; Belluti, Federica; Cavalli, Andrea. The article conveys some information:
Due to the complex and multifactorial nature of bipolar disorder (BD), single-target drugs have traditionally provided limited relief with no disease-modifying effects. In line with the polypharmacol. paradigm, we attempted to overcome these limitations by devising two series of multitarget-directed ligands endowed with both a partial agonist profile at dopamine receptor D3 (D3R) and inhibitory activity against glycogen synthase kinase 3 beta (GSK-3β). These are two structurally unrelated targets that play independent, yet connected, roles in cognition and mood regulation. Two compounds (7 and 10) emerged as promising D3R/GSK-3β multitarget-directed ligands with nanomolar activity at D3R and low-micromolar inhibition of GSK-3β, thereby confirming, albeit preliminarily, the feasibility of our strategy. Furthermore, 7 showed promising drug-like properties in stability and pharmacokinetic studies. In the experiment, the researchers used Ethyl 5-bromovalerate(cas: 14660-52-7Application of 14660-52-7)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 14660-52-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary