These common heterocyclic compound, 103273-01-4, name is 2-Bromo-4-(tert-butyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 103273-01-4
30.0 g (157.88 mmol) 2-bromo-4-tert-butylaniline, 34.6 g (157.88 mmol) 4-bromobenzoyl chloride And 300 mL THF was added and stirred at room temperature for 3 hours. After the reaction is completed, the solvent is distilled off under reduced pressure. Solidification with diisopropyl ether (IPE) gave 42.6 g (yield: 72.3%) of a white solid compound (intermediate (37)).
The synthetic route of 2-Bromo-4-(tert-butyl)aniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Raepto Co., Ltd.; Seok Mun-gi; Go Byeong-su; Im Cheol-su; Kim Hyeon-a; Kim Gyu-sik; Park Yong-pil; Han Gap-jong; Oh Yu-jin; (37 pag.)KR102059550; (2019); B1;,
Bromide – Wikipedia,
bromide – Wiktionary