One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine, Quality Control of 1575-37-7
Fasiuddin, G. S.;Liakath Ali Khan, F.;Sakthivel, S.;Muthu, S.;Irfan, Ahmad research published ã?Synthesis, Spectroscopic, Molecular Docking and inhibitory activity of 6-Bromo-2-(4-chlorophenyl)-1H-benzimidazole- a DFT approachã? the research content is summarized as follows. A novel compound 6-bromo-2-(4-chlorophenyl)-1H-benzimidazole was synthesized to treat antimicrobial infections and characterized by FT-IR, FT-Raman, 1H-NMR, UV-Vis. The stable conformer and structural optimization were carried out using the DFT-B3LYP (6-311 ++ G (d, p)) method in Gaussian 16 W. FT-IR and FT-Raman exptl. and theor. wavenumbers with the complete vibrational assignment were reported. NMR of 1H -13C and UV-Vis is calculated at different solvents using the IEF-PCM method. The conductivity, reactivity and stability of the title compound are determined by HOMO-LUMO values. The antibacterial activity was tested against S. aureus and A. niger to indicate a significant zone of inhibition than the reference drug ciprofloxacin at the concentration of 25μg/mL, and protein and ligand interaction site in docking was determined by MEP. Finally, the mol. docking between the title and the reference compound ligand with the A. niger / 3EQA was studied and compared the binding energy of the compound at the active sites.
1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Quality Control of 1575-37-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary