One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid, Computed Properties of 585-76-2
Huang, Xin;Wang, Yu-Shuang;Ma, Duo;Wang, Yuan-Yuan;Bian, Shi-Da;Zhang, Bo;Qiao, Yu;He, Zi-Ran;Lv, Meng;Cai, Guo-Long;Wang, Zi-Xuan;Liu, Xue-Song;Shi, Jing-Bo;Liu, Ming-Ming research published ã?Synthesis and biological evaluation of novel hybrids of phenylsulfonyl furoxan and phenstatin derivatives as potent anti-tumor agentsã? the research content is summarized as follows. In this study, furoxan moiety as an efficient NO donor was introduced to phenstatin, a microtubule-interfering agent (MIA), leading to the design and synthesis of a series of furoxan-based NO-releasing arylphenones derivatives I [Ar = 2-FC6H4, 4-BrC6H4, 4-ClC6H4, etc.; n= 1, 2] and II. In biol. evaluation, the synthesized compounds I and II showed moderate to potent anti-tumor activities against several human cancer cell lines, among which, compound I [Ar = 4-BrC6H4, n = 1] showed the most potent activities against both chemo-sensitive and resistant cancer cell lines with IC50 values ranging from 0.008 to 0.021μM. Further mechanistic studies revealed that I [Ar = 4-BrC6H4, n = 1] worked as a bifunctional agent exhibiting both tubulin polymerized inhibition and NO-releasing activities, resulting in potent anti-angiogenesis, colony formation inhibition, cell cycle arrest and apoptosis induction effects. In the nude mice xenograft model, I [Ar = 4-BrC6H4, n = 1] significantly inhibited the paclitaxel-resistant tumor growth with low toxicity, demonstrating the promising potential for further preclin. evaluation as a therapeutic agent, particularly for the treatment of chemo-resistant cancers.
Computed Properties of 585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary