A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Safety of 1-Bromoheptane.
Hussaini, Sunusi Y.;Haque, Rosenani A.;Haziz, Umie F. M.;Amirul, A. A.;Razali, Mohd. R. research published ã?Dinuclear silver(I)- and gold(I)-N-heterocyclic carbene complexes of N-alkyl substituted bis-benzimidazol-2-ylidenes with aliphatic spacer: Synthesis, characterizations and antibacterial studiesã? the research content is summarized as follows. New series of dinuclear Ag(I)-NHC and Au(I)-NHC complexes (NHC = N-heterocyclic carbene) bearing n-alkyl homologous series with propylene spacers were synthesized. Initially, bis-benzimidazolium salts, 1–5 were synthesized via two steps n-alkylation reaction. The salts were then subsequently deprotonated with basic metal source (Ag2O) using in-situ deprotonation method to obtain the Ag(I)-NHC complexes 6–10, resp. The Au(I)-NHC complexes, 11–15 were synthesized via transmetalation reaction from their resp. Ag(I)-NHC complexes. All compounds were fully characterized by elemental analyses, FT-IR, 1H and 13CNMR spectroscopy. The antibacterial studies of these compounds were evaluated against E. coli and S. aureus using disk diffusion method. The Ag(I)-NHC complexes exhibit better activities with inhibition zone of 11 ± 1-20 ± 1mm and 9 ± 0-16 ± 1mm against E. coli and S. aureus resp., while Au(I)-NHC complexes show inhibition zone of 7 ± 0-14 ± 1mm for both E. coli and S. aureus bacteria. All the resp. benzimidazolium salts were inactive against the bacterial strains. Herein, authors found that the antibacterial activity is enhanced by the degree of bond strength due to the match between the hardness and softness of the metal center (Lewis acid) and NHC moiety (Lewis base). In this point of view, the Ag(I)-C bond was stronger bond to NHC ligand (hard acid-hard base combination) than that of Au(I)-C (soft acid-hard base combination) which resulted the slow release of silver ions for better activity. This is due to the fact that the antibacterial activities of complexes are related with delaying in releasing the metal ions (Ag+ and Au+) into the cell membrane.
Safety of 1-Bromoheptane, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary