Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Computed Properties of 823-78-9.
Kang, Dongwei;Urhan, Cagil;Wei, Fenju;Frutos-Beltran, Estrella;Sun, Lin;Alvarez, Mar;Feng, Da;Tao, Yucen;Pannecouque, Christophe;De Clercq, Erik;Menendez-Arias, Luis;Liu, Xinyong;Zhan, Peng research published 《 Discovery, optimization, and target identification of coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors》, the research content is summarized as follows. Despite significant advances in antiretroviral therapy, acquired immunodeficiency syndrome remains as one of the leading causes of death worldwide. New antiretroviral drugs combined with updated treatment strategies are needed to improve convenience, tolerability, safety, and antiviral efficacy of available therapies. In this work, a focused library of coumarin derivatives was exploited by cell phenotypic screening to discover novel inhibitors of HIV-1 replication. Compounds I, II, III, IV and V showed moderate activity against wild-type and drug-resistant strains of HIV-1 (IIIB and RES056). Four of those mols. were identified as inhibitors of the viral RT-associated RNase H. Structural modification of the most potent III and IV led to the discovery of compound 8a. This mol. showed increased potency against wild-type HIV-1 strain (EC50 = 3.94 ± 0.22 μM) and retained activity against a panel of mutant strains, showing EC50 values ranging from 5.62 μM to 202 μM. In enzymic assays, 8a was found to inhibit the viral RNase H with an IC50 of 12.3 μM. Mol. docking studies revealed that Me 5-(7,8-dihydroxy-6-nitro-2-oxo-2H-chromene-3carboxamido)-2-hydroxybenzoate could adopt a binding mode similar to that previously reported for other active site HIV-1 RNase H inhibitors.
823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.
3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.
3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., Computed Properties of 823-78-9
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary