Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4897-84-1, formula is C5H9BrO2, The most pervasive is the naturally produced bromomethane. Formula: C5H9BrO2
Legigan, Thibaut;Migianu-Griffoni, Evelyne;Redouane, Mohamed Abdenour;Descamps, Aurelie;Deschamp, Julia;Gager, Olivier;Monteil, Maelle;Barbault, Florent;Lecouvey, Marc research published 《 Synthesis and preliminary anticancer evaluation of new triazole bisphosphonate-based isoprenoid biosynthesis inhibitors》, the research content is summarized as follows. The synthesis of a new set of triazole bisphosphonates 8a–d and 9a–d presenting an alkyl or Ph substituent at the C-4 or C-5 position of the triazole ring is described. These compounds have been evaluated for their antiproliferative activity against MIA PaCa-2 (pancreas), MDA-MB-231 (breast) and A549 (lung) human tumor cell lines. 4-Hexyl- and 4-octyltriazole bisphosphonates 8b–c both displayed remarkable antiproliferative activities with IC50 values in the micromolar range (0.75-2.4μM) and were approx. 4 to 12-fold more potent than zoledronate. Moreover, compound 8b inhibits geranylgeranyl pyrophosphate biosynthesis in MIA PaCa-2 cells which ultimately led to tumor cells death.
Formula: C5H9BrO2, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary