40161-54-4, name is 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene
(1) A suspension of Compound 1 (590 muL), Compound 2 (3162 muL), and potassium carbonate (1191 mg) in N-methylpyrrolidone (3 mL) was heated under microwave radiation at 180C for 2 hours. The reaction solution was cooled to room temperature, poured into water, and then extracted with ethyl acetate. The resultant organic layer was washed with water and saturated saline, dried, and concentrated under reduced pressure. The residue was purified with silica gel column chromatography (hexane:ethyl acetate=99:1-90:10) to give Compound 3 (3.336 g) as a colorless viscous material. MS (ESI): m/z 380/382 [M+H] +
The synthetic route of 40161-54-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; YAMAMOTO, Yasuo; SATO, Atsushi; MOROKUMA, Kenji; SHITAMA, Hiroaki; ADACHI, Takashi; MIYASHIRO, Masahiko; (260 pag.)EP3150578; (2017); A1;,
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