Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Formula: C7H4Br2O2.
Paul, Subrata;Alam, Ashraful Md.;Pal, Tarun Kumar;Uddin, Najem Md.;Islam, Monirul Md.;Sheikh, Chanmiya Md. research published 《 Quantum computational, spectroscopic investigation, molecular docking, and in vitro pharmacological studies of sulfonamide Schiff base》, the research content is summarized as follows. A new Schiff base, (E)-4-((3,5-dibromo-2-hydroxybenzylidene)amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide was synthesized and characterized by various physico-chem., X-ray crystallog. and DFT methods. The exptl. findings were compared with the computed data. The characteristic azomethine band was found at 1616 cm-1 in the exptl. FTIR spectrum. Single X-ray crystallog. data indicated that the crystal system of the compound was monoclinic with space group P21/c. The exptl. values were well correlated with the computed ones. The kinetic stability of the compound was high due to the larger HOMO-LUMO energy gap. Mol. docking and POM (Petra/Osiris/Molinspiration) investigation of the compound were also performed. POM anal. identified one antibacterial and two antitumor pharmacophore sites in the compound It exhibited higher binding energy than the reference drug in mol. docking study. The compound followed Lipinski’s rule of five and exhibited promising drug-like character and drug score. Moreover, in vitro anticancer, antibacterial, antifungal, anti-inflammatory and antioxidant properties of the compound were also carried out. It showed good antibacterial effects against S. aureus and S. typhi strains. In case of antifungal activity, the compound showed moderate inhibitory activity against both A. niger and A. flavus strains. Besides, it had the capability to stabilize the human red blood cell membrane in hypotonic solution and protect hemolysis. The highest cytotoxic activity of the compound with was observed against A549 lung cancer cells. Finally, the compound showed moderate antioxidant activity.
Formula: C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.
3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.
3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).
3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., 90-59-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary