Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Application In Synthesis of 823-78-9.
Rezaei, Elham Babazadeh;Abedinifar, Fahimeh;Azizian, Homa;Montazer, Mohammad Nazari;Asadi, Mehdi;Hosseini, Samanesadat;Sepehri, Saghi;Mohammadi-Khanaposhtani, Maryam;Biglar, Mahmood;Larijani, Bagher;Amanlou, Massoud;Mahdavi, Mohammad research published 《 Design, synthesis and evaluation of metronidazole-1,2,3-triazole derivatives as potent urease inhibitors》, the research content is summarized as follows. A new series of benzyl-(imidazolylmethyl)triazole derivatives I [R = H, 2-Me, 4-Br, etc.] was synthesized and evaluated as Helicobacter pylori urease inhibitors. All the synthesized compounds were more potent than standard inhibitor thiourea against urease. Among the synthesized compounds, compound I [R = 4-F] (IC50 = 1.975 ± 0.25μM) with inhibitory activity around 11-fols more than thiourea (IC50 = 22.00 ± 0.14μM) was the most potent compound Kinetic study of this compound revealed that compound I [R = 4-F] inhibited urease in an uncompetitive mode. Based on mol. modeling study, compound I [R = 4-F] pointed toward the bi-nickel center and stabilized by H-bond and T-shape π-π hydrophobic interactions with the critical residues His492 and Asp633. Moreover, it anchored to the helix-turn-helix motif in the active site cavity through interaction with His593 and Arg609. Consequently, it proposed that compound I [R = 4-F] through stabilization of active site flap inhibited urease activity.
823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.
3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.
3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., Application In Synthesis of 823-78-9
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary