A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Quality Control of 5392-10-9.
Saleem, Faiza;Kanwal;Khan, Khalid Mohammed;Chigurupati, Sridevi;Solangi, Mehwish;Nemala, Appala Raju;Mushtaq, Maria;Ul-Haq, Zaheer;Taha, Muhammad;Perveen, Shahnaz research published 《 Synthesis of azachalcones, their α-amylase, α-glucosidase inhibitory activities, kinetics, and molecular docking studies》, the research content is summarized as follows. Diabetes being a chronic metabolic disorder have attracted the attention of medicinal chemists and biologists. The introduction of new and potential drug candidates for the cure and treatment of diabetes has become a major concern due to its increased prevalence worldwide. In the current study, twenty-seven azachalcone derivatives were synthesized and evaluated for their antihyperglycemic activities by inhibiting α-amylase and α-glucosidase enzymes. Five compounds I (IC50 = 23.08 ± 0.03μM), (IC50 = 26.08 ± 0.43μM), II (IC50 = 24.57 ± 0.07μM), (IC50 = 27.57 ± 0.07μM), III (IC50 = 24.94 ± 0.12μM), (IC50 = 27.13 ± 0.08μM), IV (IC50 = 27.57 ± 0.07μM), (IC50 = 29.13 ± 0.18μM), and V (IC50 = 26.94 ± 0.12μM) (IC50 = 27.99 ± 0.09μM) demonstrated good inhibitory activities against α-amylase and α-glucosidase enzymes, resp. Acarbose was used as the standard in this study. Structure-activity relationship was established by considering the parent skeleton and different substitutions on aryl ring. The compounds were also subjected for kinetic studies to study their mechanism of action and they showed competitive mode of inhibition against both enzymes. The mol. docking studies have supported the results and showed that these compounds have been involved in various binding interactions within the active site of enzyme.
Quality Control of 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary