A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Related Products of 5392-10-9.
Selvaraj, Baskar;Nguyen, Uyen Tran Tu;Huh, Gyewon;Nguyen, Duc Hung;Mok, Il-Kyoon;Lee, Heesu;Kang, Kyungsu;Bae, Ae Nim;Kim, Dae Won;Lee, Jae Wook research published 《 Synthesis and biological evaluation of chalcone derivatives as neuroprotective agents against glutamate-induced HT22 mouse hippocampal neuronal cell death》, the research content is summarized as follows. Seventeen chalcone analogs were synthesized from 7-methoxy-3,4-dihydronaphthalen1(2H)-one and various aromatic aldehydes under basic conditions and their therapeutic properties were studied in mouse hippocampal cell line HT-22 against neuronal cell death induced by glutamate. From this study, we selected an analog I as a active compound which showed significantly high neuroprotection. This compound inhibited Ca2+ influx and reactive oxygen species (ROS) accumulation inside cells. The glutamate-induced cell death was analyzed by flow cytometry and it showed that I significantly reduced apoptotic or dead cell induced by 5 mM glutamate. Western blot anal. indicates that glutamate-mediated activation of MAPKs were inhibited by compound I treatment. In addition, the I enhanced Bcl-2 and decreased Bax, the anti and pro apoptotic proteins resp. Further anal. showed that, I prevented the nuclear translocation of AIF (apoptosis inducing factor) and inhibited neuronal cell death. Taken together, compound I treatment resulted in decreased neurotoxicity induced by 5 mM of glutamate. Our finding confirmed that compound I has neuro-therapeutic potential against glutamate-mediated neurotoxicity.
Related Products of 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary