Organic compounds having carbon bonded to bromine are called organic bromides. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Safety of Methyl 4-bromobutanoate.
Shao, Lihua;Bai, Yue;Wang, Qiutang;Chen, Zizhang;Xie, Yundong;Bian, Xiaoli research published 《 Design, synthesis and evaluation of 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione-Based fibrates as potential hypolipidemic and hepatoprotective agents》, the research content is summarized as follows. Six novel target compounds, 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione (ADT) based fibrates I [R1 = R2 = Me, n = 0; R1 = Et, R2 = H, n = 0; R1 = Me, R2 = H, n = 0; R1 = R2 = H, n = 2, 3, 4], were synthesized and evaluated. All the synthesized compounds were preliminarily screened by using the Triton WR-1339-induced hyperlipidemia model, in which I [R1 = R2 = Me, n = 0] (II) exhibited more potent hypolipidemic property than pos. drug fenofibrate (FF). II also significantly decreased serum triglycerides (TG), total cholesterol (TC) and low d. lipoprotein cholesterin (LDL) in methionine solution (Mets) induced hyperlipidemic mice. Moreover, hepatic transaminases (AST and ALT) were obviously ameliorated after treatment with II and the histol. observation indicated that II ameliorated the injury in liver tissue and inhibited the hepatic lipid accumulation. In the livers of II-administrated rat, the levels of PPARα related to lipids metabolism were up-regulated. Addnl. effects such as antioxidant, anti-inflammatory and H2S releasing action confirmed and reinforced the activity of II as a potential multifunctional hypolipidemic and hepatoprotective agent.
4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Safety of Methyl 4-bromobutanoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary