Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Formula: C5H9BrO2.
Sole, Daniel;Amenta, Arianna;Bennasar, M.-Lluisa;Fernandez, Israel research published 《 Palladium- and Ruthenium-Catalyzed Intramolecular Carbene CAr-H Functionalization of γ-Amino-α-diazoesters for the Synthesis of Tetrahydroquinolines》, the research content is summarized as follows. A synthetic method to prepare tetrahydroquinoline-4-carboxylic acid esters has been developed through the transition-metal-catalyzed intramol. aromatic C-H functionalization of α-diazoesters. Both [{Pd(IMes)(NQ)}2] (IMes = 1,3-dimesitylimidazol-2-ylidene, NQ = 1,4-naphthoquinone) and the first-generation Grubbs catalyst proved effective for this purpose. The ruthenium catalyst was found to be the most versatile, although in a few cases the palladium complex afforded better yields or selectivities. According to DFT calculations, Pd0– and RuII-catalyzed sp2-CAr-H functionalization proceeds through different reaction mechanisms. Thus, the Pd0-catalyzed reaction involves a Pd-mediated 1,6-H migration from the sp2-CAr-H bond to the carbene carbon atom, followed by a reductive elimination process. In contrast, electrophilic addition of the ruthenacarbene intermediate to the aromatic ring and subsequent 1,2-proton migration are operative in the Grubbs catalyst promoted reaction.
4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Formula: C5H9BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary