Electric Literature of 630-17-1,Some common heterocyclic compound, 630-17-1, name is 1-Bromo-2,2-dimethylpropane, molecular formula is C5H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Diisopropyl(2,2-dimethylpropyl)silane (51a) Magnesium (2.43 g, 100 mmol) and iodine (catalytic amount) were added to THF (100 mL), and 1-bromo-2,2-dimethylpropane (10.7 mL, 100 mmol) was added dropwise thereto for 20 minutes, followed by stirring at room temperature for 1 hour. After termination of exothermic reaction, the resultant mixture was further stirred at 50C for 5 hours, whereby 2,2-dimethylpropylmagnesium bromide THF solution was prepared. The procedure of synthesizing Compound 47a was repeated, except that the thus-prepared mixture was employed, whereby the Compound 51a was obtained as a colorless liquid (boiling point; 40 mmHg, 120.0 to 122.5C fraction, 7.65 g, 45%). 1H-NMR(CDCl3)delta 3.60 (1H, br s), 1.03-0.85 (23H, m), 0.67-0.63 (2H, m).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2,2-dimethylpropane, its application will become more common.
Reference:
Patent; TAIHO PHARMACEUTICAL COMPANY LIMITED; Sasaki, Takuma; Matsuda, Akira; EP1845102; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary