Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Safety of Methyl 4-bromobutanoate.
Wang, Yingge;Sun, Moran;Wang, Yuyang;Qin, Jinling;Zhang, Yixin;Pang, Yingyue;Yao, Yongfang;Yang, Hua;Duan, Yongtao research published 《 Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency》, the research content is summarized as follows. A novel series of cis-diphenylethene and benzophenone derivatives as tubulin/HDAC dual-targeting inhibitors were designed and synthesized. Among them, compound I exhibited the most potent antiproliferative activities against six different human cancer cell lines. I not only inhibited tubulin polymerization, disrupted cellular microtubule networks but also selectively inhibited class IIa HDACs, especially HDAC7 activity. Further, mol. docking demonstrated that I could occupy the binding pockets of tubulin and HDAC7. Cellular mechanism studies revealed that I could induce G2/M phase arrest by down-regulated expression of p-cdc2 and cell apoptosis by regulating mitochondrial membrane potential, reactive oxygen species (ROS) levels and apoptosis-related proteins (PARP, Caspase families) in a dose-dependent manner. Importantly, I significantly inhibited HUVEC tube formation, proliferation, migration, and invasion. The inhibitory effect against angiogenesis in vivo was confirmed by zebrafish xenograft. Furthermore, I could effectively suppress the proliferation and metastasis of MGC-803 cells in vitro and in a zebrafish xenograft. All the above results indicate that I can act as a promising antitumor and antiangiogenic agent via targeting tubulin and class IIa HDACs.
Safety of Methyl 4-bromobutanoate, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary