Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 20469-65-2, formula is C8H9BrO2, The most pervasive is the naturally produced bromomethane. Safety of 1-Bromo-3,5-dimethoxybenzene
Wei, Wei;Liu, Zhihao;Wu, Xiuli;Gan, Cailing;Su, Xingping;Liu, Hongyao;Que, Hanyun;Zhang, Qianyu;Xue, Qiang;Yue, Lin;Yu, Luoting;Ye, Tinghong research published 《 Synthesis and biological evaluation of indazole derivatives as anti-cancer agents》, the research content is summarized as follows. Design, synthesis and biol. evaluation of a series of indazole derivatives I [R1 = 2-aminopyrimidin-4-yl, 6-amino-3-pyridyl, 4-(4-methylpiperazin-1-yl)phenyl, etc.] was reported. In vitro antiproliferative activity screening showed that compound I [R1 = 6-(4-methylpiperazin-1-yl)-3-pyridyl] had potent growth inhibitory activity against several cancer cell lines (IC50 = 0.23-1.15μM). Treatment of the breast cancer cell line 4T1 with compound I [R1 = 6-(4-methylpiperazin-1-yl)-3-pyridyl] inhibited cell proliferation and colony formation. I [R1 = 6-(4-methylpiperazin-1-yl)-3-pyridyl] dose-dependently promoted the apoptosis of 4T1 cells, which was connected with the upregulation of cleaved caspase-3 and Bax, and down-regulation of Bcl-2. compound I [R1 = 6-(4-methylpiperazin-1-yl)-3-pyridyl] also decreased the mitochondrial membrane potential and increased the levels of reactive oxygen species (ROS) in 4T1 cells. Addnl., treatment with compound I [R1 = 6-(4-methylpiperazin-1-yl)-3-pyridyl] disrupted 4T1 cells migration and invasion, and the reduction of matrix metalloproteinase metalloproteinase-9 (MMP9) and increase of tissue inhibitor matrix metalloproteinase 2 (TIMP2) were also observed Moreover, compound I [R1 = 6-(4-methylpiperazin-1-yl)-3-pyridyl] could suppress the growth of the 4T1 tumor model without obvious side effects in vivo. Taken together, these results identified compound I [R1 = 6-(4-methylpiperazin-1-yl)-3-pyridyl] as a potential small mol. anti-cancer agent.
Safety of 1-Bromo-3,5-dimethoxybenzene, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary