Synthetic Route of 69321-60-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 69321-60-4, name is 2,6-Dibromotoluene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
2.362 g 2,6-dibromo-toluene (9.45 mmol) was dissolved in 10 mL dry THF under N2 atmosphere and the mixture was cooled to -78 C. Then 5.2 mL nBuLi (2.OM in pentane,10.4 mmol) was added dropwise and the mixture was stirred for 15 minutes. Then 2.31 mL2-isopropoxy-4,4,5 ,5-tetramethyl- 1,3 ,2-dioxaborolane (11.3 mmo 1) was added dropwise and the mixture was allowed to warm up to r.t.. It was stirred until no further conversion was observed. Then the mixture was quenched with aqueous NH4C1 solution, then extracted with EtOAc. The combined organic layer was dried over Na2SO4, filtered and thefiltrate was concentrated under reduced pressure. The crude product was purified via flash chromatography using heptane and EtOAc as eluents to obtain Preparation B7. 1H NMR(400 MHz, CDC13) oe: 7.67 (d, 1H), 7.62 (d, 1H), 7.10 (t, 1H), 2.53 (s, 3H), 1.29 (s, 12H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dibromotoluene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; SZLAVIK, Zoltan; SZABO, Zoltan; CSEKEI, Marton; PACZAL, Attila; KOTSCHY, Andras; BRUNO, Alain; GENESTE, Olivier; CHEN, I-Jen; DAVIDSON, James Edward Paul; MURRAY, James Brooke; ONDI, Levente; RADICS, Gabor; SIPOS, Szabolcs; PROSZENYAK, Agnes; PERRON-SIERRA, Francoise; BALINT, Balazs; (188 pag.)WO2016/207226; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary