Application of 38573-88-5, A common heterocyclic compound, 38573-88-5, name is 1-Bromo-2,3-difluorobenzene, molecular formula is C6H3BrF2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 23 A solution of 6.0 g of 2,3-difluorobromobenzene in 25 m of anhydrous diethyl ether was added dropwise under stirring at 10-15¡ãC to 0.66 g of magnesium metal powder, followed by reaction at room temperature for one hour so that a Grignard reagent was formed. After 4.5 g of trans-4-propylcyclohexylcyclohexenone were added under stirring at -10 to 0¡ãC to the thus-formed Grignard reagent, they were reacted at room temperature for additional 1 hour. After the completion of the reaction, diluted hydrochloric acid was added dropwise to the reaction mixture, followed by the extraction of the reaction mixture with diethyl ether. After the extract was washed with saturated NaCl, anhydrous sodium sulfate was added to dry the extract. The diethyl ether was distilled off under reduced pressure, whereby 1-(trans-4-propylcyclohexyl)-4-(2,3-difluorophenyl)-4-hydroxycyclohexene was obtained as a crude reaction product.
The synthetic route of 38573-88-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; L.C.C. CONSULTANTS CO., LTD.; CITIZEN WATCH CO. LTD.; EP571652; (1993); A1;,
Bromide – Wikipedia,
bromide – Wiktionary