On June 11, 2020, Sunwoo, Kyoung; Won, Miae; Ko, Kyung-Phil; Choi, Miri; Arambula, Jonathan F.; Chi, Sung-Gil; Sessler, Jonathan L.; Verwilst, Peter; Kim, Jong Seung published an article.Electric Literature of 83152-22-1 The title of the article was Mitochondrial Relocation of a Common Synthetic Antibiotic: A Non-genotoxic Approach to Cancer Therapy. And the article contained the following:
Tumor recurrence as a result of therapy-induced nuclear DNA lesions is a major issue in cancer treatment. Currently, only a few examples of potentially non-genotoxic drugs have been reported. Mitochondrial re-localization of ciprofloxacin, one of the most commonly prescribed synthetic antibiotics, is reported here as a new approach. Conjugation of ciprofloxacin to a tri-Ph phosphonium group (giving lead Mt-CFX) is used to enhance the concentration of ciprofloxacin in the mitochondria of cancer cells. The localization of Mt-CFX to the mitochondria induces oxidative damage to proteins, mtDNA, and lipids. A large bias in favor of mtDNA damage over nDNA was seen with Mt-CFX, contrary to classic cancer chemotherapeutics. Mt-CFX was found to reduce cancer growth in a xenograft mouse model and proved to be well tolerated. Mitochondrial re-localization of antibiotics could emerge as a useful approach to generating anticancer leads that promote cell death via the selective induction of mitochondrially mediated oxidative damage. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Electric Literature of 83152-22-1
The Article related to breast cancer cell death mitochondria ciprofloxacin, ciprofloxacin, dna damage, mitochondria, non-genotoxic cancer therapy, prodrug, reactive oxygen species, targeted therapeutics and other aspects.Electric Literature of 83152-22-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary