Author: Jessica.F

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22034-13-5, name is 4-Bromobenzo[c][1,2,5]thiadiazole, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Bromobenzo[c][1,2,5]thiadiazole

To a clear solution of B(C6F5)3 (0.050 g, 0.098 mmol) in CH2Cl2 (5 mL) was added a colorless solution of 4-bromo-benzo[2,1,3]thiadiazole (0.021 mg, 0.098 mmol) in CH2Cl2 (5 mL). The resulting yellow solution was allowed to stir for 30 minutes at room temperature. The solvent was removed in vacuo and the resulting solid washed with pentanes (2.x.10 mL) and dried under vacuum for 1 hour. The product was collected as a faint yellow solid. Recovered yield, 60 mg (85percent). Crystal’s suitable for X-ray diffraction were grown via slow diffusion of pentane into a concentrated solution of 4 in CH2Cl2. Upon addition of excess B(C6F5)3 (3 equivalents total) to 4, no change in the 1H or 19F spectrum was observed from 25 to -50° C. 1H NMR (CD2Cl2): delta 8.02 (d, 3JH-H=8 Hz, 1H, benzothiadiazole-p-CH), 7.71 (dd, 3JH-H=8 Hz, 3JH-H=8 Hz, 1H, benzothiadiazole-m-CH), 7.50 (d, 3JH-H=8 Hz, 1H, benzothiadiazole-o-CH). {1H} NMR (CD2Cl2): delta -5.5 (bs). 13C{1H} NMR (CD2Cl2, -50° C.) partial: 152.79, (s, quaternary), 149.22 (s, quaternary), 148.90 (dm, 1JC-F=250 Hz, CF), 148.22 (dm, 1JC-F=250 Hz, CF), 146.55 (dm, 1JC-F=245 Hz, CF), 141.73 (dm, 1JC-F=245 Hz, CF), 140.85 (dm, 1JC-F=250 Hz, CF), 138.99 (dm, 1JC-F=240 Hz, CF), 137.05 (dm, 1JC-F=245 Hz, CF), 136.74 (s, benzothiadiazole-m-CH), 134.01 (s, benzothiadiazole-p-CH), 131.90 (dm, 1JC-F=250 Hz, CF), 117.22 (quaternary), 116.05 (s, benzothiadiazole-o-CH). 19F NMR (CD2Cl2): delta -125.2 (br, 1F, ortho-C6F5), -131.0 (br, 3F, ortho-C6F5), -135.2 (br, 1F, ortho-C6F5), -137.2 (br, 1F, ortho-C6F5), -154.5 (s, 1F, para-C6F5), -156.5 (br, 2F, para-C6F5), -161.6 (br, 2F, meta-C6F5), 163.8 (br, 4F, meta-C6F5). 19F NMR (CD2Cl2, -50° C.): delta -125.17 (m, 1F, 3JF-F=22 Hz, ortho-C6F5), -130.58 (m, 1F, 3JF-F=21 Hz, ortho-C6F5), -131.42 (m, 2F, 3JF-F=24 Hz, ortho-C6F5), -134.13 (m, 1F, 3JF-F=24 Hz, ortho-C6F5), -137.58 (m, 1F, 3JF-F=24 Hz, ortho-C6F5), -153.99 (m, 1F, 3JF-F=20 Hz, para-C6F5), -155.31 (m, 1F, 3JF-F=20 Hz, para-C6F5), -157.27 (m, 1F, 3JF-F=22 Hz, para-C6F5), -161.28 (m, 1F, 3JF-F=20 Hz, meta-C6F5), -162.91 (m, 1F, 3JF-F=20 Hz, meta-C6F5), -162.74 (m, 1F, 3JF-F=20 Hz, meta-C6F5), -163.33 (m, 1F, 3JF-F=20 Hz, meta-C6F5), -163.77 (m, 1F, 3JF-F=22 Hz, meta-C6F5), -164.03 (m, 1F, 3JF-F=22 Hz, meta-C6F5). UV-vis: lambdamax=355 nm. X-Ray: C24H3B1Br1F15N2S1. Space Group=P-1. Cell: a=10.82(15) , b=11.82(18) , c=12.36(18) , alpha=63.7(3)°, beta=75.1(3)°, gamma=84.1(4)°, V=1369(35) 3. R=0.0432percent, Rw=0.1132percent. GOF=1.027.

According to the analysis of related databases, 22034-13-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bazan, Guillermo C.; Welch, Gregory C.; Coffin, Robert; Peet, Jeff; US2011/28656; (2011); A1;,
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Reference of 24358-62-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24358-62-1, name is 1-(4-Bromophenyl)ethylamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The corresponding ketone (20 mmol, 1.0 eq) and CH3OH (20 mL) were added to a 250 mL Schlenk tube containing [RhCp*Cl2]2 (61.8 mg, 100 mumol, 0.005 equiv) and HCOONH4 (6.36 g, 100 mmol, 5.0eq). The brown mixture was frozen, and the whole system was evacuated. The system was closed and then stirred at 70 C for 7 h. After the dark green resulting solution was cooled to room temperature, 1M aqueous HCl solution (38.4 mL) was added, and the mixture was washed twice with CH2Cl2 (5 mL) to remove the neutral compounds. After addition of a cold 12 M aqueous NaOH solution (3.6 mL) to the aqueous layer, the mixture was extracted six times with CH2Cl2 (12 mL). The combined organic layers were dried over anhydrous Na2SO4. Filtration and evaporation under reduced pressure gave crude amine,which was used without purification. All the crude corresponding amine was dissolved in dichloromethane (50 mL), and TCCA (trichloroisocyanuric acid) (3.2 g, 14 mmol) was added in a250 ml round-bottom flask at 0 C. Then, the mixture was stirred at ambient temperature during 1 h. Triethylamine (6.0 g, 6 mol) dissolved in dichloromethane (50 mL) was added, and the resulting mixture was washed with water (200 mL) and hydrochloric acid (1 M, 200 mL)successively. The organic layer was dried over anhydrous sodium sulfate. After concentration under reduced pressure, purification by column chromatography on silica gel (n-hexane/EtOAc:40/1) afforded pure product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(4-Bromophenyl)ethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chu, Benfa; Fang, Lili; Guo, Shan; Qi, Bing; Shi, Pengfei; Wang, Qi; Zhu, Jin; Tetrahedron Letters; (2020);,
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Application of 18599-22-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 18599-22-9 as follows.

General procedure: In a two-necked round-bottomed flask, equipped with a teflon-coated stirrer bar, were added iodobenzene (3a, 0.40 mL, 3.6 mmol) and Cu2O (0.027 g, 0.18 mmol), and a DMF solution of 2-Zn (0.60 M, 1.0 mL, 0.6 mmol). The whole was heated up at 100 C and stirred at that temperature for 24 h. After cooling to room temperature, the resultant was filtered through a short pad of silica gel using hexane as an eluent. The filtrate was concentrated in vacuo to give the crude materials, which was purified by silica gel column chromatography using hexanes as an eluent, leading to the corresponding compound 4a (0.036 g, 0.17 mmol) in 29% isolated yield as a colorless oil.

According to the analysis of related databases, 18599-22-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Tamamoto, Ken; Yamada, Shigeyuki; Konno, Tsutomu; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 2375 – 2383;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17247-58-4, name is (Bromomethyl)cyclobutane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of (Bromomethyl)cyclobutane

A mixture of 4-(tetramethyl-1 ,3, 2-dioxaborolan-2-yl)-1H-pyrazole (0.58 g, 2.96 mmol), (bromomethyl)cyclobutane (0.50 ml_, 4.44 mmol) and potassium carbonate (1 .23 g, 8.88 mmol) in N,N-dimethylformamide (6 mL) was heated at 100 C for 20 hours. The reaction mixture was cooled to RT, diluted with EtOAc (50 mL) and water (50 mL). The organic layer was separated, washed with water (50 mL) and brine (30 mL), dried (MgS04), concentrated under reduced pressure and purified by Biotage Isolera chromatography (25 g Silica column, using a gradient of eluents; 0-30% EtOAc in heptane) to afford the title compound (330 mg, 41 % yield) as a colourless oil. 1H NMR (250 MHz, chloroform-d) delta [ppm] 7.76 (s, 1 H), 7.64 (s, 1 H), 4.13 (d, J = 7.3 Hz, 2H), 2.95 -2.70 (m, 1 H), 2.20 – 1 .64 (m, 6H), 1 .31 (s, 12H). LCMS (Analytical Method A): Rt = 1 .13 min, MS (ESIpos): m/z = 262.9 (M+H)

The synthetic route of 17247-58-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeURLE, Stefan; DAVENPORT, Adam, James; STIMSON, Christopher; NAGEL, Jens; SCHMIDT, Nicole; ROTGERI, Andrea; GROeTICKE, Ina; RAUSCH, Alexandra; KLAR, Juergen; DYRKS, Thomas; (422 pag.)WO2018/114786; (2018); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 67344-77-8, name is 1-(3-Bromophenyl)-N-methylmethanamine, A new synthetic method of this compound is introduced below., Recommanded Product: 1-(3-Bromophenyl)-N-methylmethanamine

0. 15 g of tetrakistriphenylphosphine palladium was added at room temperature to a solution having 0.8 g of N-methyl-3-bromobenzylamine dissolved in 10 ml of toluene, followed by stirring for 5 minutes. 0.76 g of 2,4, 6- trimethylphenyl boronic acid, 3 ml of ethanol and 4.5 ml of a 2M sodium carbonate aqueous solution were sequentially added to this solution, followed by stirring for 4 hours under reflux. After cooling, 50 ml of ethyl acetate and 50 ml of a 5percent ammonium chloride aqueous solution were added, followed by stirring for a while. Then, liquid separation was carried out. The water layer was further extracted with 30 ml of ethyl acetate. Then, the organic layers were put together and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained crude product was purified by silica gel (Silica gel 60N; spherical and neutral, manufactured by Kanto Kagaku) column chromatography (developing solvent of n-hexane: ethyl acetate=1 : 1) to obtain 0.55 g of the objective compound as an oily substance. Further, NMR of this compound was as follows. 1H-NMR 5 (ppm) 2.00 (s, 6H), 2.08 (bs, lH), 2.33 (s, 3H), 2.46 (s, 3H), 3.80 (s, 3H), 6.93 (s, 2H), 7.41 (d, lH; J =7. 5 Hz), 7.08 (s, lH), 7.29 (d, lH; J =7. 5 Hz), 7.38 (t, lH; J =7.5 Hz)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ISHIHARA SANGYO KAISHA, LTD.?; WO2005/44007; (2005); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 771583-12-1, name is 2-(Aminomethyl)-4-bromoaniline, A new synthetic method of this compound is introduced below., Quality Control of 2-(Aminomethyl)-4-bromoaniline

In the 1000 ml three-necked bottle,5 g of 5-bromo-2-aminobenzylamine (molecular weight 200, 0.025 mol) was added, Add 150 ml of methylene chloride, stir, dissolve,Add 11 ml of triethylamine and cool to 0 C. Cooling and stirring, A solution of 20 ml of 4.75 g of beta-naphthoyl chloride dissolved in dichloromethane (molecular weight 190,0.025 moles) was slowly added. Natural to room temperature, stirring for 3 hours.Add 40 ml of water, separate the organic phase, evaporated,To obtain a solid intermediate product. The solid was dissolved in 60 ml of toluene,Add 4 ml of thionyl chloride, reflux for three days, cooling, product precipitation,Add 50 ml of concentrated aqueous ammonia, stir, and filter out 8.4 g of solid dihydro compound.The solid dihydro was dissolved in 80 ml of dichloromethane,Adding 2.3 g of manganese dioxide and stirring at room temperature for 18 hours to filter out the inorganic matter,The organic layer was evaporated to dryness and recrystallized to give 5.35 g of 6-bromo-2- (naphthalen-2-yl) quinazoline with a molecular weight of 334 in 64% yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Fan Hongtao; Li Yinkui; Shao Shuang; Ren Xueyan; (35 pag.)CN106554319; (2017); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 627871-16-3, name is 5-Bromo-4-fluoro-2-methylaniline, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Bromo-4-fluoro-2-methylaniline

Reference Example 52a; Pyridine (1.0 mL) and acetyl chloride (0.67 mL) were sequentially added to a methylene chloride (17 mL) solution of 5-bromo-4-fluoro-2-methylaniline (1.74 g), followed by stirring at room temperature for 1 hour. Water, 1 mol/L hydrochloric acid, and chloroform were added to the reaction mixture. The organic layer was separated, washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. Hexane was added to the obtained residue, and the solid substance was collected by filtration to obtain 1.83 g of N-(5-bromo-4-fluoro-2-methylphenyl)acetamide as a white solid.1H-NMR (DMSO-d6) delta: 2.06 (3H, s), 2.18 (3H, s), 7.27 (1H, d, J=9.5 Hz), 7.74 (1H, d, J=6.8 Hz), 9.38 (1H, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Toyama Chemical Co., Ltd.; US2011/275797; (2011); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 18599-22-9, name is 4-Bromo-3,3,4,4-tetrafluorobut-1-ene, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 4-Bromo-3,3,4,4-tetrafluorobut-1-ene

Under an argon atmosphere, methyl lithium-diethyl ether solution (1.0 M, 2.2 mL) without containing lithium bromide was dropped to tetrahydrofuran solution (2.0 mL) of 4-bromo-3,3,4,4-tetrafluoro-1-butene (0.23 g, 1.1 mmol) and 4- (trans-4-propylcyclohexyl) benzaldehyde (0.55 g, 2.4 mmol) at -78 C and stirred for 2 hours. After that, saturated ammonium chloride aqueous solution was poured into the reaction solution and reaction was stopped. The reaction solution was extracted three times with ethyl acetate, the obtained organic layer was dried with anhydrous sodium sulfate. After drying, filtration was carried out, and the obtained filtrate was concentrated with rotary evaporator. After that, the residue was purified by silica gel column chromatography (hexane / ethyl acetate = 7/1), compound (9-B) was obtained. (0.32 g, 0.88 mmol, 81% yield)

According to the analysis of related databases, 18599-22-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AGC Seimi Chemical Co., Ltd.; Konno, Tsutomu; Ishihara, Takashi; Asai, Tomoyuki; (24 pag.)JP2016/84300; (2016); A;,
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Synthetic Route of 627871-16-3,Some common heterocyclic compound, 627871-16-3, name is 5-Bromo-4-fluoro-2-methylaniline, molecular formula is C7H7BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under a nitrogen atmosphere, 5-bromo-4-fluoro-2-methylaniline (2.0 g, 9.80 mmol),Bis (pinacolato) diboron (3.73 g, 14.7 mmol),Palladium acetate (220 mg, 0.98 mmol),X-Phos (701 mg, 1.47 mmoll) and potassium acetate (2.89 g, 29.4 mmol) were suspended in 1,4-dioxane (20 mL),Under heating reflux,Stir for 1.5 hours.It was allowed to cool, diluted with water, and extracted with ethyl acetate.Wash the organic layer with saturated saline,Dried over anhydrous magnesium sulfate,The solvent was distilled off under reduced pressure.The obtained residue was purified by silica gel column chromatography (hexane-ethyl acetate),Compound 14(1.65g,Yield 67.0%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-4-fluoro-2-methylaniline, its application will become more common.

Reference:
Patent; Shionogi Co Ltd; Ogawa, Tomoyuki; (39 pag.)JP2019/182806; (2019); A;,
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These common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 4-(4-Bromophenyl)dibenzo[b,d]furan

Under an argon atmosphere, the intermediate body 3H-1 (2.36 g, 7.3 mmol), an intermediate body 3H-2 (3.0 g, 7.3 mmol), CuI (1.4 g, 7.3 mmol), tripotassium phosphate (2.3 g, 11 mmol), anhydrous dioxane (30 mL), and cyclohexanediamine (0.84 g, 7.3 mmol) were loaded in the stated order into a three-necked flask, and were then stirred at 100 C. for 8 hours. Water was added to the reaction liquid to precipitate a solid, and then the solid was washed with hexane and then with methanol. Further, the resultant solid was purified by silica gel column chromatography. Thus, a compound 3H (2.9 g, 60% yield) was obtained. The result of FD-MS analysis confirmed that the compound had a ratio m/e of 650 with respect to its molecular weight, i.e., 650.

The synthetic route of 4-(4-Bromophenyl)dibenzo[b,d]furan has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IDEMITSU KOSAN CO. LTD.; UNIVERSAL DISPLAY CORPORATION; Yamamoto, Hitoshi; Weaver, Michael S.; Brown, Julia J.; Nishimura, Kazuki; Iwakuma, Toshihiro; (76 pag.)US9966541; (2018); B2;,
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