Author: Jessica.F

Electric Literature of 69321-60-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 69321-60-4 name is 2,6-Dibromotoluene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

DESCRIPTION FOR D933-bromo-2-methylbenzaldehyde (D93)To a solution of 1,3-dibromo-2-methylbenzene (3 g, 12.00 mmol) in Tetrahydrofuran (THF) (100 mL) stirred under nitrogen at -78 C. was added BuLi (9.00 mL, 14.40 mmol) dropwise. The reaction mixture was stirred at -78 C. for 20 min. DMF (1.115 mL, 14.40 mmol) was added dropwise. The reaction mixture was continuously stirred for 2 hours. The reaction was quenched with sat. aq. ammonia chloride solution. The aqueous layers were separated and extracted by EA for 3 times. The combined organic layers were washed by brine, dried over anhydrous sodium sulfate. The dried solution was concentrated in vacuo to afford 3-bromo-2-methylbenzaldehyde (D93) (2.4 g), which was used for the next step without further purification. MS (ES): C8H7BrO requires 197.9. found 199 (M+H+)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,6-Dibromotoluene, and friends who are interested can also refer to it.

Reference:
Patent; Glaxo Group Limited; US2011/269738; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 6627-78-7, A common heterocyclic compound, 6627-78-7, name is 1-Bromo-4-methylnaphthalene, molecular formula is C11H9Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

b. 5.0 g (0.0226 mole) of 1-bromo-4-methylnaphthalene, 3.2 g (0.0233 mole) of anthranilic acid, 3.0 g (0.0215 mole) of anhydrous potassium carbonate and 0.1 g of copper powder were heated in 35 ml of nitrobenzene at 190 to 195 C. for 1 hour while introducing nitrogen gas. The reaction product was cooled and the nitrobenzene as the solvent was completely removed by steam distillation. The residual aqueous solution was made slightly acidic with 2N hydrochloric acid. The precipitated crystal was washed with water and dried to obtain a crude crystal. Recrystallization from ethanol gave yellow needles crystal having a decomposition point of 215 to 217 C. As a result of the infrared absorption spectrum analysis and the mixed examination, it was found that this product was indentical with the compound obtained in the above method a).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Ikeda Mohando Co., Ltd.; US3989746; (1976); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 17247-58-4, The chemical industry reduces the impact on the environment during synthesis 17247-58-4, name is (Bromomethyl)cyclobutane, I believe this compound will play a more active role in future production and life.

Sodium sulfite (1.3 g; WAKO), ethanol (3.9 mL), and water (5.8 mL) were added to (bromomethyl)cyclobutane (0.8 mL; Ald), the resulting mixture was stirred at 100 C. for 2 hours, and the solvent was evaporated under reduced pressure. Toluene (10 mL), DMF (20 muL), and thionyl chloride (1.9 mL; TCI) were successively added to the residue, the resulting mixture was stirred at 110 C. for 5 hours, and the solvent was evaporated under reduced pressure. This residue was used instead of ethanesulfonyl chloride described in the step of Reference Example N-2 to give the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Bromomethyl)cyclobutane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASAHI KASEI PHARMA CORPORATION; US2010/261701; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 57190-17-7,Some common heterocyclic compound, 57190-17-7, name is 2-Bromo-1,3-diisopropylbenzene, molecular formula is C12H17Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a mixture of Pd(OAc)2 (23 mg, 0.1 mmol), DPE-Phos (125 mg,0.2 mmol), and Cs2CO3 (652 mg, 2.0 mmol) was added a solutionof 4a (496 mg, 1.0 mmol) and 2-bromo-1,3,5-trimethylbenzene(300 mg, 1.5 mmol) in 1,4-dioxane (15 mL) under N2, and the reactionmixture was heated at 110 C for 17 h with stirring. After coolingto r.t., and removal of solvents, the mixture was extracted withCH2Cl2 (3 × 20 mL), and the combined organic extracts werewashed with brine (20 mL) and dried (Na2SO4). Purification of theresidual oil by column chromatography on silica gel (hexanes-EtOAc, 10:1) afforded 5a

The synthetic route of 57190-17-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhu, Shifa; Wang, Chao; Zhao, Songxian; Xiao, Yelin; Hu, Lang; Huang, Zhipeng; Synthesis; vol. 46; 2; (2014); p. 212 – 224;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 67344-77-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67344-77-8, name is 1-(3-Bromophenyl)-N-methylmethanamine, This compound has unique chemical properties. The synthetic route is as follows.

Intermediate A (1.50 g, 7.5 mmol), pyridine-3-boronic acid (0.97 g, 7.9 mmol), Pd(PPh3)4 (0.44 g, 0.38 mmol) and K2C03 (2.68 g, 18.8 mmol) were placed in a 20 mL microwave reaction vial. The vessel was sealed with a crimp-cap septum and then was twice evacuated under hi- vacuum and flushed with nitrogen. THF (11 .5 mL) and H20 (5.5 mL) were added by syringe, theevacuation/nitrogen flush procedure was repeated and the vessel contents were then heated at reflux 0/N. After cooling to rt, the reaction mixture was partitioned between Et0Ac and H20 and the layers were separated. The aqueous layer was extracted twice with Et0Ac and the organic phases were combined, dried over MgS04 and concentrated in vacuo. Flash chromatography of the residue on silica gel eluting with an increasing proportion of Me0H (0.5 to 10percent) in DCM andevaporation of solvents in vacuo afforded Intermediate B as a faint-orange oil.

The chemical industry reduces the impact on the environment during synthesis 1-(3-Bromophenyl)-N-methylmethanamine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; VAL-CHUM, LIMITED PARTNERSHIP; MADIRAJU, S.R. Murthy; PRENTKI, Marc; JOLY, Erik; ZHAO, Shangang; WO2015/127559; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 52997-43-0, name is 7-(Bromomethyl)pentadecane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52997-43-0, Safety of 7-(Bromomethyl)pentadecane

General procedure: The solution of dihydroxyacetophenone (4, 1.0 equiv.), anhydrous potassium carbonate (2.0 equiv.) and corresponding alkyl bromides (1.1 equiv.) in acetonitrile was stirred at 70-80 C for 4-5 h. After evaporation of acetonitrile, the reaction mixture was diluted with dichloromethane and washed with water three times. The organic layer was dried with anhydrous sodium sulfate and evaporated under reduced pressure. The crude product was purified by column chromatography to give 5.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Venkateswararao, Eeda; Sharma, Vinay K.; Lee, Ki-Cheul; Sharma, Niti; Park, Sun-Hong; Kim, Youngsoo; Jung, Sang-Hun; European Journal of Medicinal Chemistry; vol. 54; (2012); p. 379 – 386;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 3017-70-7, The chemical industry reduces the impact on the environment during synthesis 3017-70-7, name is 2-Bromo-3-methyl-2-butene, I believe this compound will play a more active role in future production and life.

[00333] In a reaction tube under nitrogen, a mixture of PdCl2(dppf)CH2Cl2 (21 mg; 0.026 mmol), triethylamine (0.36 ml; 2.58 mmol), 2-bromo-3-methyl-2-butene (132 mg; 0.886 mmol), 1.29M HB(pin) in dioxane (1.00 ml; 1.29 mmol) and N-methylacetamide (39 mg; 0.53 mmol) in dioxane (4 ml; dried over 4 ? sieves) was sealed and stirred at 80 C. GC analysis after 24 hours showed formation of the desired alkenylborate compound which was also identified by GC/MS.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-3-methyl-2-butene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Commonwealth Scientific and Industrial Research Organisation; US6680401; (2004); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22385-77-9, name is 1-Bromo-3,5-di-tert-butylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 1-Bromo-3,5-di-tert-butylbenzene

Bis(pinacolato)diboron (6.89 g, 27.1 mmol) , KOAc (7.01 g, 71.4 mmol), 13 (5.62 g, 20.9 mmol) and 25 mL of dioxane were sparged with Ar for 1 h. Pd(dppf)Cl2 (341 mg, 0.418 mmol) was added and the reaction was sparged for an additional 20 min. The reaction was then refluxed overnight. The reaction was then cooled to room temperature and quenched with 50 mL of sat. NH4Cl and diluted with 75 mL of distilled water and extracted 3 x with 75 mL of Et2O. The combined organics were washed with 75 mL of water and 75 of brine, dried with magnesium sulfate, treated with activated charcoal, and filtered in through a pad of celite. The solvents were removed under vacuum. The product was isolated with column chromatography to afford a white solid (3.31 g, 50percent), mp 175-178 C (lit.7 mp 179 C). 1H NMR (CDCl3): delta 7.67 (s, 2H), 7.55 (s, 1H), 1.35 (s, 30H). The 1H NMR matches the known spectrum.7

The synthetic route of 22385-77-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Dressler, Justin J.; Miller, Sarah A.; Meeuwsen, Brian T.; Riel, Asia Marie S.; Dahl, Bart J.; Tetrahedron; vol. 71; 2; (2015); p. 283 – 292;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C6H5BrN4

To a solution of Intermediate B (195 mg, 0.91 mmol) in THF at -78 0C under N2 was added dropwise n-butyllithium (1.46 ml, 3.66 mmol). The reaction mixture was stirred for 15 min and then gaseous ethylene oxide was bubbled into the reaction mixture for 5 min. The diy-ice bath was removed and warmed up to rt. Analytical HPLC found a new peak and then the reaction was quenched with 2 ml saturated aq NH4Cl followed by addition of 10 ml EtOAc and H2O (2ml). The organic phase was collected and washed with brine and dried over Na2SO4 and evaporated to crude as yellow oil. The crude was dissolved in 5 ml 10%MeOH/CH2Cl2 and 4 ml silica gel was added and then solvent evaporated. The crude in the silica gel was loaded on an MPLC column and was eluted with a gradient 0 – 10%MeOH in CH2Cl2 to give 20 mg of the desired product. ; MS [M+H]+ = 178.9; LCMS RT = 1.1 min

The synthetic route of 937046-98-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2007/64931; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1295502-53-2, name is 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole

Dry 250mL three-necked flask was added compound 2 (3.87g, 5mmol), 4,7- dibromo-5,6-difluorobenzo [c] [1,2,5] thiadiazole (1.65g, 5mmol) , 120mL THF, and Pd (PPh3)Cl2(105mg, 0.15mmol); and dissolved with stirring, using a vacuum pump with nitrogen 3 times; the reaction temperature was raised to 70 24 hours; direct cooling to room temperature rotary evaporation, and dichloromethane: petroleum ether (1: 5) as eluent agent over a silica gel column to give an orange solid component is the desired product (1.97 g of, 46% yield);

The synthetic route of 1295502-53-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; National Center for Nanoscience and Technology (NCNST); Wei, Zhixiang; Yuan, liu; (22 pag.)CN105315273; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary