Author: Jessica.F

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69902-83-6, name is 1-Bromo-2-methyl-3-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H6BrF3

Bromo-3- (trifluoromethyl) -2-methylbenzene (5.0 g, 20.9 mmol),Bromosuccinimide (3.72 g, 20.9 mmol),Azobisisobutyronitrile (300 mg) was dissolved in dry carbon tetrachloride (100 mL)Heat under reflux for 16 hours under nitrogen.The reaction was cooled to room temperature and filtered,The filtrate was added imidazole (2.85 g, 42 mmol) and potassium carbonate (4.34 g, 31.37 mmol)Heat under reflux for 5 hours under nitrogen.LC-MS showed the reaction was complete,The reaction solution was filtered,The filtrate was concentrated,The residue was dissolved in dichloromethane (50 mL)Wash with water (2 × 40 mL).Organic phase filtration,concentrate,The residue was purified by flash silica gel column to give 1- (2-bromo-6- (trifluoromethyl) benzyl) -1H-imidazole (5.0 g).

According to the analysis of related databases, 69902-83-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Tong Chaolong; Bao Rudi; Li Yuannian; (67 pag.)CN107312005; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 90562-10-0, name is 1-Bromo-4-(3-bromopropyl)benzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 90562-10-0, Recommanded Product: 90562-10-0

The reaction mixture of 28 (0.20 g, 0.59 mmol) and 1-bromo-4-(3-bromopropyl)benzene (46) (0.22 g, 0.79 mmol) in dry 1,4-dioxane (8 ml) was stirred for 5 days to afford the title compound as a white solid in 60% yield (0.22 g). mp: 219-220 C; 1H-NMR (500 MHz, DMSO-d6): delta = 7.24-7.29 (m, 14H), 6.73 (s, 1H), 5.17 (m, 1H), 3.83 (m, 1H), 3.21-3.38 (m, 6H), 3.05 (m, 1H), 2.53 (m, 2H), 1.47-2.22 (m, 7H); 13C-NMR (125 MHz, DMSO-d6): delta = 172.8, 139.8, 130.7, 128.8, 128.5, 128.3, 128.1, 127.6, 127.5, 81.2, 69.0, 62.9, 59.9, 54.2, 31.5, 23.9, 20.9, 18.1; HRMS calcd. for C30H33Br1N1O3 [M]+: 534.1638; found: m/z = 534.1644; HPLC (Method A): tR (min) = 13.98 (97%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Yamashita, Yasunobu; Tanaka, Ken-ichiro; Yamakawa; Asano; Kanda, Yuki; Takafuji; Kawahara, Masahiro; Takenaga, Mitsuko; Fukunishi, Yoshifumi; Mizushima; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3339 – 3346;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 766-96-1, name is 1-Bromo-4-ethynylbenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-4-ethynylbenzene

To a 50 mL test tube was added the crude product from above (0.306 g, 1.69 mmol), 1-bromo-4-iodobenzene(0.478 g, 1.69 mmol), Pd(PPh3)4 (0.057 g, 0.05 mmol), and CuI (0.019 g, 0.10 mmol). To a separate test tubewas added tetrahydrofuran (20 mL), and triethylamine (5 mL). Each tube was sealed with a rubber septumand purged with a continuous stream of argon (5 min). The contents of the liquids tube were transferred tothe solids tube via cannula under argon. The resulting mixture was stirred at 50C under argon for 24 h. Theresulting suspension was extracted between dichloromethane and 5% NH4OH (aq). The organic layer wasseparated and dried over MgSO4. After filtration to remove the drying agent, the solvent was removed viarotary evaporation to give a brown-orange powder. 1H NMR spectrum matched that previously described.8This crude 4,4?-dibromotolane product was used directly in the next step without further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Christensen, Joseph A.; Fletcher, James T.; Tetrahedron Letters; vol. 55; 33; (2014); p. 4612 – 4615;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89523-51-3, name is 5-Bromobenzo[c]phenanthrene, A new synthetic method of this compound is introduced below., COA of Formula: C18H11Br

Example 4 Synthesis of 5-(diphenylamino)benzo[c]phenanthrene 190 mul (1 mmol) of chlorodi-tert-butylphosphine and then 112 mg (0.5 mmol) of palladium(II) acetate are added to a suspension of 15.3 g (50 mmol) of 5-bromobenzo[c]phenanthrene, 10.2 g (60 mmol) of diphenylamine and 7.7 g (80 mmol) of sodium tert-butoxide in 500 ml of toluene, and the mixture is subsequently heated under reflux for 5 h. After the mixture has been cooled to 60 C., 500 ml of water are added, the organic phase is separated off, filtered through silica gel, evaporated virtually to dryness at 80 C. in vacuo, and 300 ml of ethanol are then added. After cooling, the solid is filtered off with suction. The product is purified by recrystallisation from dioxane five times (about 8 ml/g). Yield: 12.6 g (32 mmol), 64.1%, purity 99.9% (HPLC).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Merck Patent GmbH; US2011/288292; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6698-13-1, name is 4-Bromo-1,3-benzodioxole, A new synthetic method of this compound is introduced below., Safety of 4-Bromo-1,3-benzodioxole

[0907] Method 3: To a stirred mixture of 5-(4-fluorophenyl)-4-methylpyridin-2(1H)-one (2.04 g, 10 mmol, 1.0 eq.), 4-bromobenzo[d][1,3]dioxole (3.0 g, 15 mmol, 1.5 eq.), and K2C03 (2.76 g, 20 mmol, 2eq.) in DMF (50 mL) was added CuT (191 mg, 1 mmol, 0.1 eq.) and 8- hydroxyquinoline (140 mg, 1 mmol, 0.1 eq.). The reaction mixture was stuffed at 140C for 3 days under N2 protection. The mixture was cooled to rt, diluted with EA (250 mL), washed with water and brine, concentrated. The residue was purified by flash chromatography on silica gel (PE:EA=5:1-*1:1) to yield Compound 184 (680 mg, 21% yield) as white solid. ?H NMR (CDC13, 400 MHz) (57.35-7.32 (m, 2H), 7.26 (s, 1H), 7.18 (t, J=8.8Hz, 2H), 7.02-6.94 (m, 3H), 6.67 (s, 1H),6.13 (s, 2H), 2.21 (s, 3H). MS (ES) m/z [M+Hf? 323.8.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; INTERMUNE, INC.; RAMPHAL, Johnnie, Y.; BUCKMAN, Brad, Owen; EMAYAN, Kumaraswamy; NICHOLAS, John, Beamond; SEIWERT, Scott, D.; WO2015/153683; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 5153-40-2,Some common heterocyclic compound, 5153-40-2, name is 1-Bromo-2,3,4,5,6-pentamethylbenzene, molecular formula is C11H15Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of 15.92 g (80 mmol) 2,4,6-Me3C6H2Br in 80 mL THF was added dropwise to 2.32 g (96 mmol) Mg, activated with 3 g (16 mmol) 1,2-Br2C2H4, in 20 mL THF. The reaction mixture was refluxed for 2 h and afterward allowed to cool to r.t. To the Grignard reagent solution was added dropwise a solution of 7.55 g (16 mmol) 2,4,6-I3C6H2OH and0.44 g (0.64 mmol) [(IPr)PdCl2(3-ClC5H4N)]. The reaction mixture was refluxed for another 21 h and quenched with2 mL H2O stirring under argon for 30 min. After solvent removal, the obtained residue was dissolved in 80 mL Et2Oand 20 mL CH2Cl2 and filtered over a 2 cm alumina pad. Solvent removal at reduced pressure afforded a brown oil which was eluted over a 10 cm alumina column witha mixture of Et2O-pentane 2:1 (v/v). To the pale-yellow oil obtained after the solvent removal, methanol was added. After sonication, 1 precipitated as a colorless solid. Filtration and vacuum drying afforded 3.8 g (52 %) of 1.

The synthetic route of 5153-40-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; olea, Atena B.; Olaru, Marian; Silvestru, Cristian; Ra, Ciprian I.; Zeitschrift fur Naturforschung – Section B Journal of Chemical Sciences; vol. 70; 1; (2015); p. 77 – 81;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 112279-60-4,Some common heterocyclic compound, 112279-60-4, name is 4-Bromo-2,5-difluoroaniline, molecular formula is C6H4BrF2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 197 5,8-Difluoro-1,2-dihydro-6-(3-nitrophenyl)-2,2,4-trimethylquinoline (Compound 297, structure 83 of Scheme XXI, where R1 =R3-5 =R7 =R9 =H, R2 =nitro, R6 =R8 =fluoro) This compound was prepared by the same procedure as described in the synthesis of Compound 291 (EXAMPLE 191) from 4-bromo-2,5-difluoroaniline (32 mg, 0.13 mmol) and 3-nitrobenzeneboronic acid (167 mg, 1.0 mmol) to afford 3 mg (10%) of Compound 297 as a colorless oil. Data for Compound 297: 1 H-NMR(400 MHz, CDCl3) 8.33 (t, J=1.6, 1H), 8.14 (dd, J=8.0, 1.6, 1H), 7.78 (d, J=8.0, 1H), 7.57 (t, J=8.0, 1H), 6.94 (dd, J=10.8, 6.3, 1H), 5.37 (s, 1H), 4.16 (bs, 1H), 2.17 (dd, J=7.0, 1.3, 3H), 1.34 (s, 6H).

The synthetic route of 112279-60-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ligand Pharmaceuticals Incorporated; US5688810; (1997); A;,
Bromide – Wikipedia,
bromide – Wiktionary

90562-10-0, name is 1-Bromo-4-(3-bromopropyl)benzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 1-Bromo-4-(3-bromopropyl)benzene

EXAMPLE 23 3-[(N-(3-(4-Bromo-phenyl)-propyl)-piperidin-3-yl)-methyl]7,8dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one-hydrochloride Prepared from 3-[(piperidin-3-yl)-methyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one and 3-(4-bromophenyl)propyl bromide analogously to Example 1. Yield: 34.8% of theory, Melting point: 100-104 C.

The synthetic route of 90562-10-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Boehringer Ingelheim GmbH; US5175157; (1992); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 28148-04-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28148-04-1, name is 1,3-Dibromo-2-methylpropane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The beta- lactam carbonyl compound of the formula shown in C6H5-COCH2CONH-CH31.0mmol added 50 ml round bottomFlask, and then followed by adding K2CO32.4mmol, tetrabutylammonium bromide 0.07mmol, ammonium acetate 1.2mmol, 1,3- dibromo-2-Methyl propane 1.2mmol and 30mL of deionized water and mix well. The reaction was continued stirring at 30 deg C 8.0 hours, stoppedThe reaction, was filtered, dried, purified by recrystallization methanamine obtained after 5-benzoyl-6- methyl-3,4-dihydro-pyran-3, 87% yield of product.

The synthetic route of 1,3-Dibromo-2-methylpropane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Huaihua University; Xiang, Dexuan; Liang, Chunhua; Liu, Yilin; Xiang, Bailin; Zhang, Li; (9 pag.)CN105541770; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 89523-51-3, These common heterocyclic compound, 89523-51-3, name is 5-Bromobenzo[c]phenanthrene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Argon atmosphere, 2-nitro-phenylboronic acid 2.00g, 5-bromo-benzo [c] phenanthrene, 6.12g, tetrakis triphenylphosphine palladium (0) 0.462g, DME 80mL, 2M aqueous sodium carbonate solution in the flask was added 40mL and the mixture was heated and stirred 24 hr reflux. after cooling to room temperature (25 ), after the reaction solution was extracted using toluene, and removing the water layer, an organic layer was washed with saturated aqueous sodium chloride. The organic layer was dried over magnesium sulfate, concentrated, and the residue was purified by silica gel column chromatography to give 5- (2-nitro-phenyl) benzo [c] phenanthrene was obtained a 5.72g.

The synthetic route of 89523-51-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Idemitsu Kosan Corporation; Kawamura, Masahiro; Mizuki, Yumiko; Ito, Hirokazu; Hayama, Tomoharu; Haketa, Tasuku; (69 pag.)KR2015/126340; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary