Author: Jessica.F

In an article, author is Motamedi, Zahra, once mentioned the application of 143-15-7, Name is 1-Bromododecane, molecular formula is C12H25Br, molecular weight is 249.2309, MDL number is MFCD00000225, category is bromides-buliding-blocks. Now introduce a scientific discovery about this category, Application In Synthesis of 1-Bromododecane.

Combined Effects of Protocatechuic Acid and 5-Fluorouracil on p53 Gene Expression and Apoptosis in Gastric Adenocarcinoma Cells

Objectives: This study evaluated the combined effects of protocatechuic acid (PCA) and 5-fluorouracil (5-FU) on gastric adenocarcinoma (AGS) cells. Materials and Methods: The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, colony formation assay, flow cytometry technique, real-time quantitative polymerase chain reaction, and Western blotting were used to investigate cytotoxic effects, colony formation, apoptosis, p53 gene expression, and Bcl-2 protein level in AGS cells treated with 5-FU and PCA. Results: Our results demonstrated that PCA (500 mu M) alone or in combination with 5-FU (10 mu M) inhibited AGS cell proliferation, inhibited a colony formation, and increased apoptosis compared with untreated control cells. Moreover, the combined 5-FU/PCA exposure led to upregulation of p53 and downregulation of Bcl-2 protein when compared to the untreated control cells. Conclusion: The results demonstrate that the combined 5-FU/PCA may promote antiproliferative and pro-apoptotic effects with the inhibition of colony formation in AGS cells. The mechanisms by which the combined 5-FU/PCA exposure exerts its effects are associated with upregulation of p53 gene expression and downregulation of Bcl-2 level. Therefore, the combination of 5-FU with PCA not only could be a promising approach to potentially reduce the dose requirements of 5-FU but also could promote apoptosis via p53 and Bcl-2 signaling pathways.

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C18H37Br, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 112-89-0, Name is 1-Bromooctadecane, molecular formula is C18H37Br. In an article, author is Shull, Timothy E.,once mentioned of 112-89-0.

Inhibition of Fusarium oxysporum f. sp. nicotianae Growth by Phenylpropanoid Pathway Intermediates

Fusarium wilt in tobacco caused by the fungus Fusarium oxysporum f. sp. nicotianae is a disease-management challenge worldwide, as there are few effective and environmentally benign chemical agents for its control. This challenge results in substantial losses in both the quality and yield of tobacco products. Based on an in vitro analysis of the effects of different phenylpropanoid intermediates, we found that the early intermediates trans-cinnamic acid and para-coumaric acid effectively inhibit the mycelial growth of F. oxysporum f. sp. nicotianae strain FW316F, whereas the downstream intermediates quercetin and caffeic acid exhibit no fungicidal properties. Therefore, our in vitro screen suggests that trans-cinnamic acid and para-coumaric acid are promising chemical agents and natural lead compounds for the suppression of F. oxysporum f. sp. nicotianae growth.

If you¡¯re interested in learning more about 112-89-0. The above is the message from the blog manager. Formula: C18H37Br.

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 2635-13-4, Name is 5-Bromobenzo[d][1,3]dioxole, molecular formula is C7H5BrO2. In an article, author is Wu, Shuang,once mentioned of 2635-13-4, Name: 5-Bromobenzo[d][1,3]dioxole.

Thermodynamic modeling of the MBr-BaBr2 (M = Alkali metals) systems

The complete thermodynamic optimizations of MBr-BaBr2 (M = Li, Na, K, Rb, Cs) systems were performed based on thermodynamic principles using CALPHAD approach. In this work, the existence of BaBr2-based solid solubility was firstly evaluated according to the corresponding liquid curves in available literature by the limiting liquidus slope equation and ideal liquid curve. The liquid enthalpy of mixing for LiBr-BaBr2 binary system was calculated via empirical prediction method. The Gibbs energy of liquid molten mixtures were modeled by the substitutional solution model (SSM) and the associate solution model (ASM), while that of the double salts were processed into stoichiometric compounds based on the Neumann-Kopp technique. The thermodynamic database with a series of thermodynamic properties and phase equilibria data of investigated systems were successfully established by optimizing model parameters. The simulated results could provide theoretical guidance and technical support, as well as applying in the design for the multi-components eutectic materials by combination with the binary alkali metal bromide systems.

If you¡¯re interested in learning more about 2635-13-4. The above is the message from the blog manager. Name: 5-Bromobenzo[d][1,3]dioxole.

In an article, author is Baumeler, Thomas, once mentioned the application of 58534-95-5, Formula: C6H5BrFN, Name is 3-Bromo-2-fluoroaniline, molecular formula is C6H5BrFN, molecular weight is 190.013, MDL number is MFCD09864700, category is bromides-buliding-blocks. Now introduce a scientific discovery about this category.

Minimizing the Trade-Off between Photocurrent and Photovoltage in Triple-Cation Mixed-Halide Perovskite Solar Cells

Its lower bandgap makes formamidinium lead iodide (FAPbI(3)) a more suitable candidate for single-junction solar cells than pure methylammonium lead iodide (MAPbI(3)). However, its structural and thermodynamic stability is improved by introducing a significant amount of MA and bromide, both of which increase the bandgap and amplify trade-off between the photocurrent and photovoltage. Here, we simultaneously stabilized FAPbI(3 )into a cubic lattice and minimized the formation of photoinactive phases such as hexagonal FAPbI(3) and PbI2 by introducing 5% MAPbBr(3) , as revealed by synchrotron X-ray scattering. We were able to stabilize the composition (FA(0.95)MA(0.05)Cs(0.05))Pb(I-0.95 Br-0.05)(3), which exhibits a minimal trade-off between the photocurrent and photovoltage. This material shows low energetic disorder and improved charge-carrier dynamics as revealed by photothermal deflection spectroscopy (PDS) and transient absorption spectroscopy (TAS), respectively. This allowed the fabrication of operationally stable perovskite solar cells yielding reproducible efficiencies approaching 22%.

If you are interested in 58534-95-5, you can contact me at any time and look forward to more communication. Formula: C6H5BrFN.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5003-71-4, Name is 3-Bromopropan-1-amine hydrobromide, molecular formula is C3H9Br2N. In an article, author is Heshmati, Masoumeh,once mentioned of 5003-71-4, Computed Properties of C3H9Br2N.

Cytotoxicity and genotoxicity of silver nanoparticles in Chinese Hamster ovary cell line (CHO-K1) cells

Biomedical and pharmaceutical products comprising silver nanoparticles are attracting interest due to their potent antibacterial activities. For their safe use it has become imperative to test their cyto-genotoxic potential. In the present study the cytotoxicity and genotoxicity of three different sizes of AgNPs ranging from 15 to 22 nm and at concentrations 0.005-500 mu g/ml were studied in Chinese Hamster ovary cell line (CHO-K1) cells. Cytoxicity was assessed by MTT [3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide] assay and for genotoxicity comet, and micronucleus assays were utilized. AgNPs were able to internalize CHO-K1 cells and cause cytotoxicity at concentrations 0.005-500 mu g/ml. AgNP-induced cyto-genotoxicity in CHO-K1 cells could be attributed to its smaller primary size. AgNP-C of size similar to 15 nm was the most potent among the three AgNPs. The genotoxic response was biphasic that increased at lower concentrations (0.005-0.025 mu g/ml) and decreased at higher concentrations (0.05-0.1 mu g/ml) after 24 h of exposure. Such potential in vitro genotoxic effect of AgNPs remains to be further confirmed in animal cells in vivo.

Interested yet? Keep reading other articles of 5003-71-4, you can contact me at any time and look forward to more communication. Computed Properties of C3H9Br2N.

Synthetic Route of 76006-33-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 76006-33-2, Name is 3-Bromo-2-methylbenzoic acid, SMILES is O=C(O)C1=CC=CC(Br)=C1C, belongs to bromides-buliding-blocks compound. In a article, author is Abbasi, Maryam, introduce new discover of the category.

Bio-Fe3O4-MNPs catalyzed green synthesis of pyrrolo[2,1-a]isoquinoline derivatives using isoquinolium bromide salts: study of antioxidant activity

In this research, a novel, one-pot, efficient procedure with high yield for the synthesis of pyrrolo[2,1-a]isoquinoline derivatives using multi-component reaction of isoquinoline, alkyl bromides, and triphenylphosphine in the presence of Fe3O4-MNPs as catalyst under solvent-free conditions at room temperature is investigated. This study highlights an easy, simple, rapid, and clean method for the preparation of pyrrolo[2,1-a]isoquinoline derivatives. The Fe3O4-MNPs in these reactions were produced employing a green procedure by reduction of ferric chloride solution with pomegranate peel water extract. Additionally, antioxidant activity was studied for the some newly synthesized compounds such as 5a-5d using the DPPH radical trapping and reducing potential of ferric ion experiments and comparing the results with the results of synthetic antioxidants (2-tert-butylhydroquinone, TBHQ; butylated hydroxytoluene, BHT). As a result, compounds 5a-5d show trace DPPH radical trapping and excellent reducing power of ferric ion.

Synthetic Route of 76006-33-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 76006-33-2 is helpful to your research.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, SDS of cas: 1119-94-4, 1119-94-4, Name is Dodecyl trimethyl ammonium bromide, SMILES is CCCCCCCCCCCC[N+](C)(C)C.[Br-], belongs to bromides-buliding-blocks compound. In a document, author is Eliseenkov, E. V., introduce the new discover.

Characterization of Substituted 1,3-Dioxolanes and 1,3-Dioxanes by Gas Chromatography-Mass Spectrometry

Until recently, one of the reasons for the unsatisfactory characterization of alicyclic ketals of aliphatic and alkylaromatic ketones was the absence of any mention of the presence of such compounds in natural samples. Another reason is in the low yields of such ketals on the interaction of ketones and diols under the conditions of conventional acid catalysis. To optimize the synthesis of trace amounts of such ketals, we used cobalt(II) bromide and dimethyl glyoxime as catalysts. The simplest chromatographic parameters, including the difference between the retention indices of the products and the starting compounds (difference in retention indices, DRI), are effective for identifying the target ketals in reaction mixtures. Such combined chromatography-mass spectrometric characteristics as homologous increments of retention indices (i(RI)) are informative not only for the group identification of analytes (assignment to the corresponding homologous series) and the assessment of their molecular weights (at low-intense signals of molecular ions). They are also useful for the determination of the total number of branches of the sp(3)-carbon skeleton of molecules (N) using the regression of N approximate to ai(RI) + b.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1119-94-4. SDS of cas: 1119-94-4.

Application of 14660-52-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 14660-52-7, Name is Ethyl 5-bromovalerate, SMILES is C(C(OCC)=O)CCCBr, belongs to bromides-buliding-blocks compound. In a article, author is Kolmel, Dominik K., introduce new discover of the category.

Photoredox cross-electrophile coupling in DNA-encoded chemistry

A catalytic manifold that enables photoredox cross-electrophile coupling of alkyl bromides with DNA-tagged aryl iodides in aqueous solution is presented. This metallaphotoredox transformation was aided by the identification of a new pyridyl bis(carboxamidine) ligand, which proved critical to the nickel catalytic cycle. The described C(sp(2))-C(sp(3)) coupling tolerates a wide range of both DNA-tagged aryl iodides as well as alkyl bromides. Importantly, this reaction was optimized for parallel synthesis, which is a paramount prerequisite for the preparation of combinatorial libraries, by using a 96-well plate-compatible blue LED array as the light source. Therefore, this mild and DNA-compatible transformation is well positioned for the construction of DNA-encoded libraries. (C) 2020 Elsevier Inc. All rights reserved.

Application of 14660-52-7, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 14660-52-7.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 768-90-1, Name is 1-Bromoadamantane, molecular formula is C10H15Br, belongs to bromides-buliding-blocks compound. In a document, author is Huang, Hai-Yun, introduce the new discover, HPLC of Formula: C10H15Br.

Effective Tools for the Metal-catalyzed Regiodivergent Direct Arylations of (Hetero)arenes

The direct functionalization of two different C-H bonds of the same organic molecule using different procedures – also called regiodivergent C-H bond functionalization – currently represents an important research topic in organic chemistry, as it demonstrates the versatility of C-H bond functionalization methodology. Over the last decade, the number of tools to control such regiodivergent C-H bond functionalizations has increased significantly. In this account, we will present the various tools that allowed us to arylate different positions of various (hetero)arenes, via a C-H bond functionalization, using palladium or ruthenium catalysis.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 768-90-1. HPLC of Formula: C10H15Br.

In an article, author is Ghosh, Swagatika, once mentioned the application of 41459-42-1, Safety of 3-Bromo-2-(bromomethyl)propanoic acid, Name is 3-Bromo-2-(bromomethyl)propanoic acid, molecular formula is C4H6Br2O2, molecular weight is 245.9, MDL number is MFCD00010643, category is bromides-buliding-blocks. Now introduce a scientific discovery about this category.

Synthesis, characterization and antimicrobial evaluation of some novel 1,2,4-triazolo [3,4-b][1,3,4]thiadiazine bearing substituted phenylquinolin-2-one moiety

Pathogenic microbes have mutated and developed resistance to the latest range of antibiotics, which has kept synthetic chemist hunting for better and least toxic antimicrobial agents. Cyclocondensation of substituted anilines with 3-phenyl-2-propenoic acid yielded Phenyl-(substituted)-quinolin-2-one derivatives (1a1t). In the next step phenylquinolin-2-one acetic acid derivatives (2a2t) were prepared by the treatment of (1a1t) with chloroacetic acid. Further (2a2t) derivatives were reacted with thiocarbohydrazide to obtain a series of 4-amino-5-sulfanyl-4,5-dihydro-1,2,4-triazolo-4-pheny-(substituted)-quinolin-2-one derivatives (3a3t). Then condensation of (3a3t) with phenacyl bromide provided series of fused heterocyclic derivatives of 4-phenyl-1-({6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl}methyl)-(substituted)-1,2-dihydro quinolin-2-one (4a4t). Structures of these newly synthesized derivatives were established by elemental analysis, FT-IR, 1H NMR and Mass spectroscopy. Final derivatives (4a4t) were screened for their in vitro antibacterial and antifungal activities against the standard drugs Ampicillin and Fluconazole respectively. The compounds 4d, 4g and 4j showed potent activity against all the studied microbes. Particularly compounds substituted with halogen groups at para position of phenylquinoline ring exhibited significant antimicrobial activity against studied microbes.(C) 2015 Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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