Author: Jessica.F

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, A new synthetic method of this compound is introduced below., COA of Formula: C12H8Br2

An integrated flow microreactor system consisting of four T-shaped micromixers (M1,M2, M3 and M4), four microtube reactors (R1, R2, R3 and R4), and five microtube units [P1(inner diameter = 1000 m, length l = 100 cm), P2 (= 1000 m, l = 50 cm), P3 (= 1000m, l = 100 cm), P4 (= 1000 m, l = 50 cm), P5 (= 1000 m, l = 100 cm)] was used. Thewhole flow microreactor system was dipped in a water bass (24 ). A solution of 5,6-dibromoacenaphthene (0.10 M) in THF (flowrate = 6.00 mL min-1) and a solution of BuLi (0.50 M) in hexane (flow rate = 1.20 mL min-1) were introduced to M1 (= 250 m). The resulting solution was passed through R1 (phi= 500 mum, l = 3.5 cm) and was mixed with a solution of benzophenone (0.20 M) in THF (flow rate = 3.00 mL min-1) in M2 (phi= 500 mum). The resulting solution was passed through R2 (phi= 1000 mum, l = 200 cm) and was introduced to M3 (phi= 500 mum) where the solution was mixed with a solution of BuLi (0.50 M) in hexane (flow rate = 1.44 mLmin-1). The resulting solution was passed through R3 (phi= 1000 mum, l = 200 cm) and was introduced to M4 (phi= 500 mum) where the solution was mixed with a solution of 4,4′-difluorobenzophenone (0.20 M) in THF (flow rate = 3.60 mL min-1). The resulting solution was passed through R4 (phi= 1000 mum, l = 200 cm). After a steady state was reached, the product solution was collected for 130 s and was stirred for 4 h at 22 C under argon. Then the mixture was treated with BuLi (1.59 M) in hexane (6.8 mL) to consume excess ketones at -78 C. The resultant solution was further stirred for 2 h, and was treated with water.

The synthetic route of 19190-91-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Suzuki, Takanori; Uchimura, Yasuto; Nagasawa, Fumika; Takeda, Takashi; Kawai, Hidetoshi; Katoono, Ryo; Fujiwara, Kenshu; Murakoshi, Kei; Fukushima, Takanori; Nagaki, Aiichiro; Yoshida, Jun-Ichi; Chemistry Letters; vol. 43; 1; (2014); p. 86 – 88;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 18599-22-9 as follows. HPLC of Formula: C4H3BrF4

4-bromo-3,3,4,4-tetrafluoro-1-butene (8.7 g, 42 mmol), anthracene (5.0 g, 28 mmol) and toluene (100 g) were added to a 300 mL pressure-resistant reaction container, and a reaction was conducted at 150 C. for 24 hours. Subsequently, after cooling to room temperature, the resultant was concentrated using a rotary evaporator. Methanol (50 g) was added to the concentrate, followed by stirring. The precipitated solid was subjected to filtration. Then, the residue was dried under reduced pressure, so as to obtain intermediate product 14 (6.0 g, yield=55.6%).

According to the analysis of related databases, 18599-22-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOKYO OHKA KOGYO CO., LTD.; ARAI, Masatoshi; MAEHASHI, Takaya; IKEDA, Takuya; (95 pag.)US2018/149973; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4333-56-6 as follows. Product Details of 4333-56-6

To a stirred solution of cyclopropyl bromide (4.0 mL, 50 mmol) in 120 mL of ether at-78C was added dropwise a 1.7M solution of t-butyllithium in pentane (44.5 mL, 75.7 mmol). After 10 min, cooling bath was removed, stirring was continued for 1.5 h. The mixture was cooled again in a-78C bath, and 3-furaldehyde (3.5 mL, 41.9 mmol) was added. Reaction was continued for 1 h, and quenched with a saturated NH4CI aqueous solution. The aqueous mixture was extracted with CH2CI2 (100 mL x 3). The organic extracts were washed with brine, dried by Na2SO4, filtered, and concentrated in vacuo to give 5.3 g (91 %) of the alcohol product as a yellow oil.

According to the analysis of related databases, 4333-56-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/68460; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 445-02-3, name is 4-Bromo-2-(trifluoromethyl)aniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 445-02-3, Recommanded Product: 4-Bromo-2-(trifluoromethyl)aniline

EXAMPLE 19 (E)-3-Cyclopentyl-2-[4-(5-methyl-tetrazol-1-yl)-3-trifluoromethyl-phenyl]-N-thiazol-2-yl-acrylamide A solution of 2-(trifluoromethyl)-4-bromoaniline (4.8 g, 20 mmol) in dry tetrahydrofuran (20 mL) was cooled to 0 C. and then treated with acetic anhydride (8.2 g, 80 mmol). The reaction mixture was stirred at 0 C. for 10 min and then allowed to warm to 25 C. The reaction mixture was stirred at 25 C. for 2 h, at which time, thin layer chromatography analysis of the reaction mixture indicated the absence of starting material. The reaction mixture was then concentrated in vacuo. The crude residue precipitated from diethyl ether (50 mL) and hexanes (50 mL). The solid was collected by filtrated and washed with hexanes to afford N-(4-bromo-2-trifluoromethyl-phenyl)-acetamide (5.07 g, 90%) as an amorphous white solid: EI-HRMS m/e calcd for C9H7BrF3NO (M+) 281.8352, found 281.8348.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Sidduri, Achyutharao; US2002/35266; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 202865-83-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202865-83-6, name is 1-Bromo-3-fluoro-5-methylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To an oven-dried 5 mL screw-capped vial, N-(5-chloroquinolin-8-yl)butyramide (1a) (75 mg, 0.3mmol), heptafluoroisopropyl iodide (178 mg, 0.60 mmol), Pd(OAc)2 (6.7 mg, 0.03 mmol),1-AdCOOH (10.8 mg, 0.06 mmol), K2CO3 (124 mg, 0.9 mmol), toluene (276 mg, 3.0 mmol) andchlorobenzene (0.7 mL) were added in a glove box. The mixture was stirred for 48 h at 140 Cfollowed by cooling. The resulting mixture was filtered through a celite pad and concentrated invacuo. The residue was purified by column chromatography on silica gel (eluent: hexane/EtOAc=2/1) to afford the desired alkylated product 2a (61 mg, 60%) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-fluoro-5-methylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kubo, Teruhiko; Aihara, Yoshinori; Chatani, Naoto; Chemistry Letters; vol. 44; 10; (2015); p. 1365 – 1367;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 2862-39-7, The chemical industry reduces the impact on the environment during synthesis 2862-39-7, name is 2-Bromo-N,N-dimethylethanamine hydrobromide, I believe this compound will play a more active role in future production and life.

50 ml of N,N-dimethylformamide and 7.37 g of dimethylaminobromoethane hydrobromide were added to the reaction vessel.(0 ¡¤ 0318 mol), adding 5 g of potassium carbonate, stirring at room temperature for 15 min, adding 4.5 g of 2-benzylpyridine (0.0265 mol), heating to 80 C for 5 h, monitoring by TLC, filtering while hot, adding 150 ml of water and 150 ml of filtrate. Extracted with ethyl acetate and extracted with 100 ml of ethyl acetate.The ethyl acetate phases were combined and concentrated to give 6 g of Pheniramine.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N,N-dimethylethanamine hydrobromide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Zhongsheng Pharmaceutical Co., Ltd.; Guangdong Xian Qiang Pharmaceutical Co., Ltd.; Tan Zhenyou; Deng Jun; CN108164455; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 955959-84-9, These common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

0.21 g of palladium(II) acetate, xylene (20 mL), and 0.76 g of tri-tert-butylphosphine are added,Stirred at 60 ¡ãC for 30 minutes.The above solution was added to a flask heated to 60¡ãC under nitrogen to give the above compound 2 (7,9-Dihydrobenzo[4,5]furo[2,3-g]benzofurano[2′,3′:4,5]indolo[2,3-b]carbazole 7.4g), 4-(4-Bromophenyl)dibenzo[b,d]furan (13.2 g) and sodium tert-butoxide 5.2 g (54 mmol) were added to the above solution together with xylene (180 mL). Then, it heated up at 130 ¡ãC, and it heat-stirred for 6 hours. After cooling to room temperature, 200 mL of water was added. After the organic layer was extracted with chloroform, the organic layer was dried over MgSO 4 , the solvent was removed, and silica gel column chromatography was performed to give Compound A-9 (7.4 g, 47percent).

The synthetic route of 955959-84-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Co., Ltd. LG Chemical; Hong Wanshao; He Zaicheng; Xu Shangde; Jin Zhengfan; Li Zaizhuo; Jin Yuanhuan; (73 pag.)CN108017654; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 2635-13-4, name is 5-Bromobenzo[d][1,3]dioxole, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2635-13-4, Product Details of 2635-13-4

Step 1a. 5-Bromo-6-iodobenzo[d][1,3]dioxole (Compound 0102-1) A solution of 5-bromobenzo[d][1,3]dioxole (10.0 g, 50.0 mmol), anhydrous acetonitrile (150 mL), TFA (11.4 g, 100.0 mmol) and NIS (33.7 g, 150.0 mmol) was stirred at room temperature for 24 h. The solvent was removed under reduce pressure and the crude purified by column chromatography on silica gel (petroleum) to yield the title compound 0107-1 as a white solid (18.5 g, 91%): 1H NMR (DMSO-d6) delta 5.99 (s, 2H), 7.10 (s, 1H), 7.26 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromobenzo[d][1,3]dioxole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Cai, Xiong; Qian, Changgeng; US2010/184801; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4549-33-1, name is 1,9-Dibromononane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C9H18Br2

General procedure: To a stirred solution of 2-(phenylsulfonyl)methyl-4,5-diphenyloxazole 1 (500 mg, 1.33 mmol, 1.0 equiv) in dry THF (10 mL) was added potassium tert-butoxide (1.60 mmol, 1.2 equiv) at 5 C. The resulting yellow reaction mixture was stirred under a nitrogen atmosphere (30 min). The dibromo alkane (1.60 mmol, 1.2 equiv) was then slowly added to the reaction mixture by syringe, and reaction mixture was allowed to warm to room temperature and stirring was continued (16 h). After completion of reaction, cold water (10 mL) was poured into the reaction mixture followed by extraction with dichloromethane (2 x 20 mL). The organic layers were combined, washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude residue was submitted to gravity-column chromatography (hexane/ethyl acetate, 9:1) to afford the corresponding products 2a-d.

The synthetic route of 4549-33-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Patil, Pravin C.; Luzzio, Frederick A.; Tetrahedron; vol. 73; 29; (2017); p. 4206 – 4213;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 203302-95-8, name is 4-Bromo-3,5-difluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., category: bromides-buliding-blocks

4-bromo-3, 5-difluoroaniline (500 mg, 2.4 mmol), 2-trifluoromethoxybenzeneboronic acid (590 mg, 2.9 mmol), Pd2(dppf)Cl2 (98 mg, 0.12 mmol), cesium carbonate (2.35 g, 7.2 mmol) and acetonitrile/water (10 mL/1 mL) were added to a microwave tube. The mixture was nitrogen sparged for 5 min, stirred and heated to 120 C for 1 hour under microwave, washed with saturated ammonium chloride (20 mL), and separated by silica gel column (petroleum ether: ethyl acetate = 50:1) to give the product of 2,6-difluoro-2?-trifluoromethoxy-[1,1?-biphenylyl]-4-amine (yellow oil, 460 mg), with a yield of 66.3%. 1H NMR (400 MHz, CDCl3) delta 7.47-7.28 (m, 4H), 6.29-6.27 (d, J= 9.1Hz, 2H), 3.67 (s, 2H). MS (ESI) m/z: 290.1 (MH+).

According to the analysis of related databases, 203302-95-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Fudan University; WANG, Yonghui; HUANG, Yafei; YU, Fazhi; TANG, Ting; EP3476829; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary