Author: Jessica.F

Kakinami, Takaaki published the artcileHalogenation using quaternary ammonium polyhalides. XXV. Bromination of acetanilides with benzyltrimethylammonium tribromide-zinc chloride system, Formula: C10H16Br3N, the publication is Nippon Kagaku Kaishi (1990), 705-8, database is CAplus.

The reaction of acetanilides with equimolar amounts of PhCH₂N⁺Me₃ Br₃^– and ZnCl₂ in AcOH under mild conditions gave the bromo-substituted acetanilides in good yields. E.g., AcNHC₆H₃Me₂-3,5 gave 99% AcNHC₆HBr₂Me₂-2,4,3,5.

Nippon Kagaku Kaishi published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Formula: C10H16Br3N.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Miura, Yozo published the artcileSyntheses and Characterization of Poly(1,3-phenylene-2-amino-1,3-phenylene)s and Dimer and Tetramer Model Compounds, HPLC of Formula: 111865-47-5, the publication is Macromolecules (1998), 31(7), 2041-2046, database is CAplus.

The Pd-catalyzed cross-coupling polycondensation of 2,6-dibromoaniline or 2,6-dibromo-4-tert-butylaniline with 1,3-phenylenebis(trimethylene boronate) in benzene-water in the presence of K₂CO₃ and Bu₄NCl gave poly(1,3-phenylene-2-amino-1,3-phenylene)s in 56-86% yields. The number average mol. weights of the poly(1,3-phenylene)s determined by GPC using styrene standards are 2500-5720, which correspond to the d.p. of 15.0-25.6. The thermal stabilities of the polyphenylenes were evaluated by thermal gravimetry. The corresponding dimer and tetramer model compounds of poly(1,3-phenylene-2-amino-1,3-phenylene)s were prepared, and their properties were compared with those of the poly(1,3-phenylene)s.

Macromolecules published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, HPLC of Formula: 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Herberich, Gerhard E. published the artcileDerivatives of borole. V. Synthesis of [1-(diisopropylamino)borole]metal complexes and the Diels-Alder dimer of 1-(diisopropylamino)borole, Category: bromides-buliding-blocks, the publication is Chemische Berichte (1985), 118(11), 4303-13, database is CAplus.

Oxidation of Li [1-(diisopropylamino)borolenediide] (I) with SnCl₂ forms the Diels-Alder dimer II. I is a versatile reagent for the formation of [1-(diisopropylamino)borole]metal complexes. Suitable substrates are metal halides (CoBr₃·DME, NiCl₂·DME), organometallic metal halides, and simple metal halides in the presence of CO. Thermal reactions of II with carbonyl compounds may also give borole complexes. Fifteen compounds of Cr, Mn, Fe, Co, Ni, Ru, and Rh, including triple-decked complexes, are described.

Chemische Berichte published new progress about 18346-57-1. 18346-57-1 belongs to bromides-buliding-blocks, auxiliary class Cobalt, name is Cobalt(II) dibromo(1,2-dimethoxyethane), and the molecular formula is C4H10Br2CoO2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kitagawara, Yumina published the artcileNovel bioactivation pathway of benzbromarone mediated by cytochrome P450, Application of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Drug Metabolism & Disposition (2015), 43(9), 1303-1306, database is CAplus and MEDLINE.

Benzbromarone (BBR) is a hepatotoxic drug, but the detailed mechanism of its toxicity remains unknown. We identified 2,6-dibromohydroquinone (DBH) and mono-debrominated catechol (2-ethyl-3-(3-bromo-4,5-dihydroxybenzoyl)benzofuran; CAT) as novel metabolites of BBR in rat and human liver microsomal systems by comparison with chem. synthesized authentic compounds, and we also elucidated that DBH is formed by cytochrome P 450 2C9 and that CAT is formed mainly by CYP1A1, 2D6, 2E1, and 3A4. Furthermore, CAT, DBH, and the oxidized form of DBH are highly cytotoxic in HepG2 compared with BBR. Taken together, our data demonstrate that DBH, a novel reactive metabolite, may be relevant to BBR-induced hepatotoxicity.

Drug Metabolism & Disposition published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Application of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Namkoong, Yon published the artcileElectrochemiluminescent detection of glucose in human serum by BODIPY-based chemodosimeters for hydrogen peroxide using accelerated self-immolation of boronates, Safety of 2-(4-(Bromomethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(55), 7577-7580, database is CAplus and MEDLINE.

BODIPY-based ECL chemodosimeters were developed for the detection of hydrogen peroxide. The reactivity of boronate towards hydrogen peroxide was enhanced by adjacent fluorine atoms. In combination with glucose oxidase, a fluorine-substituted probe successfully quantified the glucose level in human serum, providing its potential as a versatile tool in point-of-care testing applications.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1029439-49-3. 1029439-49-3 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronate Esters,Boronic acid and ester,, name is 2-(4-(Bromomethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H17BBrFO2, Safety of 2-(4-(Bromomethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yoakim, Christiane published the artcileβ-Lactam Derivatives as Inhibitors of Human Cytomegalovirus Protease, COA of Formula: C8H6BrF3S, the publication is Journal of Medicinal Chemistry (1998), 41(15), 2882-2891, database is CAplus and MEDLINE.

The development of novel monobactam inhibitors of HCMV protease incorporating a carbon side chain at C-4 and a urea function at N-1 is described. Substitution with small groups at the C-3 position of the β-lactam ring gave an increase in enzymic activity and in stability; however, a lack of selectivity against other serine proteases was noted. The use of both tri- and tetrasubstituted urea functionalities gave effective inhibitors of HCMV protease. Benzyl substitution of the urea moiety was beneficial, especially when strong electron-withdrawing groups where attached at the para position. Modest antiviral activity was found in a plaque reduction assay.

Journal of Medicinal Chemistry published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C9H8BNO2, COA of Formula: C8H6BrF3S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Namba, Yoshiyuki published the artcileCrystal structure and the molecular behavior of 2,3-dibromo-2,3-dimethylbutane at room temperature, Name: 2,3-Dibromo-2,3-dimethylbutane, the publication is Bulletin of the Chemical Society of Japan (1970), 43(3), 677-81, database is CAplus.

The crystal structure of 2,3-dibromo-2,3-dimethylbutane at room temperature has a disordered nature. In the crystal, trans-form mols. have at least 4 orientations of equal statistical weight around the axes parallel to the [001] direction. Therefore, in spite of the low symmetry of the mol., the crystal belongs to the tetragonal system and has the space group of I4/mmm, while a = 7.38, c = 8.12 Å, and Z = 2.

Bulletin of the Chemical Society of Japan published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Name: 2,3-Dibromo-2,3-dimethylbutane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Koide, Tsutomu published the artcileDielectric study of solid 2,3-dibromo-2,3-dimethylbutane, Formula: C6H12Br2, the publication is Nippon Kagaku Zasshi (1970), 91(7), 622-5, database is CAplus.

The dielec. constant (D) of a crystal of 2,3-dibromo-2,3-dimethyl-butane was measured at 5-100 kHz at -170 to 100°. The measurements were made with an a.c. bridge. The sample was made by pressing crystal powder. The compactness was 0.98. No significant change of D was found at the transition point of -90°, while remarkable change was observed at another transition point of 70-80°. At -90 to 70°, D was ∼2.6. The theoretical value of D was calculated by the equation of Froelich, the result of which showed that the trans model was more favorable than the model of trans-gauche equilibrium

Nippon Kagaku Zasshi published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Formula: C6H12Br2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Martinez, Gabriel Espinosa published the artcileAccessing Pincer Bis(carbene) Ni(IV) Complexes from Ni(II) via Halogen and Halogen Surrogates, SDS of cas: 111865-47-5, the publication is Journal of the American Chemical Society (2016), 138(13), 4290-4293, database is CAplus and MEDLINE.

This communication describes the two-electron oxidation of (^DIPPCCC)NiX (^DIPPCCC = bis(diisopropylphenyl-benzimidazol-2-ylidene)phenyl; X = Cl or Br) with halogen and halogen surrogates to form (^DIPPCCC)NiX₃. These complexes represent a rare oxidation state of Ni, as well as an unprecedented reaction pathway to access these species through Br₂ and halogen surrogate (benzyltrimethylammonium tribromide). The Ni(IV) complexes were characterized by a suite of spectroscopic techniques and can readily reduce to the Ni(II) counterpart, allowing for cycling between the Ni(II)/Ni(IV) oxidation states.

Journal of the American Chemical Society published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, SDS of cas: 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Akagi, Katsuhiko published the artcileRelative reactivities of organic halides in displacement reactions. V. Effect of substituent on the reactivity of ω-substituted primary alkyl halides in the reaction with sodium thiosulfate, Category: bromides-buliding-blocks, the publication is Journal of the American Chemical Society (1956), 4034-7, database is CAplus.

Br(CH₂)₃SEt, b₅ 54-6°, n_D²⁰ 1.5113 (obtained from Br(CH₂)₃Br and NaSEt in poor yield) oxidized with 30% H₂O₂ in AcOH yielded 66% Br(CH₂)₃SO₂Et (XIX), b₄ 140°. Similarly was prepared Br(CH₂)₂SO₂Et (XX), b_3.5 126-8°. The rate constants for the reaction with Na₂S₂O₃ in 50% EtOH were determined by the method of Crowell and Hammett (C.A. 43, 1632h) for the following compounds (k × 10³ 1./mole/sec. at the temperatures indicated in parentheses, and heat and entropy of activation in kcal./mole and e.u., resp., given): EtBr, 0.298 ± 0.003 (12.3°), 1.07 ± 0.01 (24.9°), 3.33 ± 0.03 (37.3°), 16.2, -15.7; PrBr, 0.175 ± 0.001 (12.3°), 0.631 ± 0.004 (24.9°), 1.94 ± 0.02 (37.3°), 16.2, -16.9; BuBr, 0.132 ± 0.001 (12.3°) 0.465 ± 0.003 (24.9°), 1.47 ± 0.01 (37.3°), 16.1, -17.5; Br(CH₂)₂OEt (b₇₆₀ 125°), 0.344 ± 0.002 (37.3°), 1.16 ± 0.02 (49.8°), 3.44 ± 0.02 (62.5°), 18.3, -13.7°; Br(CH₂)₃OEt, 0.407 ± 0.003 (24.9°), 1.36 ± 0.01 (37.3°), 4.04 ± 0.02 (49.8°), 17.0, -15.0; (BrCH₂)₄OEt, 0.726 ± 0.007 (24.9°), 2.35 ± 0.02 (37.3°), 6.74 ± 0.06 (49.8°), 16.5, -15.6; Br(CH₂)₂Cl, 0.107 ± 0.002 (24.9°), 0.376 ± 0.003 (37.3°), 1.26 ± 0.01 (49.8°), 18.3, -13.5°; Cl(CH₂)₃Br, 0.405 ± 0.002 (24.9°), 1.35 ± 0.01 (37.3°), 4.26 ± 0.01 (49.8°), 17.4, -13.6; Br(CH₂)₄Cl, (b₁₁₀ 103-4°), 0.197 ± 0.002 (12.3°), 0.734 ± 0.002 (24.9°), 2.33 ± 0.01 (37.3°), 16.6, -15.0; XX, 0.722 ± 0.011 (24.9°), 2.60 ± 0.05 (37.3°), 8.08 ± 0.18 (49.8°), 19.2, -9.2; Br(CH₂)₃SO₂Et (b₄ 140°), 3.58 ± 0.11 (24.9°), 12.3 ± 0.3 (37.3°), 33.3 ± 0.1 (49.8°), 17.2, -12.3°; Ph(CH₂)₃Br, 0.890 ± 0.006 (37.3°), 3.24 ± 0.03 (49.8°), 8.47 ± 0.01 (62.5°), 17.9, -13.0; Ph(CH₂)₃Br, 0.417 ± 0.002 (24.9°), 1.53 ± 0.02 (37.3°), 4.65 ± 0.03 (49.8°), 17.9, -12.0; Ph(CH₂)₄Br, 1.36 ± 0.02 (37.3°), 4.34 ± 0.02 (49.8°), 12.8 ± 0.1 (62.5°), 17.8, -12.4; CH₂:CHCH₂Cl, 0.932 ± 0.01 (12.2°), 2.51 ± 0.04 (24.6°), 7.33 ± 0.03 (37.4°), 13.8, -21.7°; trans-CHCl:CHCH₂Cl (b₇₆₀ 111°, n_D²⁰ 1.4751), 1.60 ± 0.08 (12.2°), 4.94 ± 0.05 (24.6°), 13.7 ± 0.1 (37.4°), 14.5, -18.3; cis-CHCl:CHCH₂Cl (b₇₆₀ 104°, n_D²⁰ 1.4687), 2.59 ± 0.03 (12.2°), 7.42 ± 0.07 (24.6°), 21.6 ± 0.5 (37.4°), 14.4, -17.7; ClCH:CHCO₂Et, 1.71 ± 0.07 (12.3°), 5.36 ± 0.21 (24.9°), 18.0 ± 0.6 (37.3°), 15.8, -13.7.

Journal of the American Chemical Society published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C3H7BrO2S, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary