Author: Jessica.F

Kajigaeshi, Shoji published the artcileOxidation using quaternary ammonium polyhalides. IV. Selective oxidation of sulfides to sulfoxides with benzyltrimethylammonium tribromide, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Bulletin of the Chemical Society of Japan (1989), 62(10), 3376-7, database is CAplus.

The reaction of sulfides with a stoichiometric amount of benzyltrimethylammonium tribromide and aqueous sodium hydroxide in dichloromethane at room temperature or in 1,2-dichloroethane under reflux gave the corresponding sulfoxides in good yields.

Bulletin of the Chemical Society of Japan published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kajigaeshi, Shoji published the artcileOxidation of thiols to disulfides with benzyltrimethylammonium tribromide, Quality Control of 111865-47-5, the publication is Chemistry Express (1991), 6(2), 129-32, database is CAplus.

Oxidation of RSH (R = Me₂CH, Me(CH₂)_n, n = 2-5, 7, PhCH₂, p-MeC₆H₄, p-ClC₆H₄, Ph, o-, p-tolyl, 2-benzothiazolyl) with benzyltrimethylammonium tribromide and NaOH in CH₂Cl₂-H₂O at room temperature gave 60-99% 13 RSSR.

Chemistry Express published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Quality Control of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kono, Takahiro published the artcileSynthesis and photo-electrochemical properties of novel thienopyrazine and quinoxaline derivatives, and their dye-sensitized solar cell performance, Quality Control of 52431-30-8, the publication is Organic Electronics (2012), 13(12), 3097-3101, database is CAplus.

Light absorption from visible to NIR region is required to increase the photocurrent and to enhance the photo-energy conversion efficiencies in dye-sensitized solar cells (DSSCs). We have now developed novel thienopyrazine dye TP1 which has absorption up to 700 nm. Quinoxaline dye QX2 with absorption at shorter wavelengths than TP1 has been synthesized for comparisons. The power conversion efficiencies of DSSCs with TP1 and QX2 showed 4.4% and 3.2%, resp. The absorption edge in IPCE of TP1 reached 800 nm and the open circuit voltage (Voc) of QX2 was high (0.77 V). To improve the device performances, QX2 was used as a co-adsorbent dye with TP1. In the mixed sensitizer based DSSC, a high power conversion efficiency of 6.2% was achieved due to the effective light harvesting and steric effect of QX2.

Organic Electronics published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Quality Control of 52431-30-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rakowitz, Dietmar published the artcileOn the synthesis of bioisosteres of O-benzothiazolyl-oxybenzoic acids and evaluation as aldose reductase inhibitors, Formula: C7H5Br2F, the publication is Archiv der Pharmazie (Weinheim, Germany) (2005), 338(9), 419-426, database is CAplus and MEDLINE.

A series of compounds characterized by bioisosteric replacement of pharmacophores were prepd, e.g., I (R = CH(=NOH) or NO₂) and tested as aldose reductase inhibitors (ARIs). On the one hand, the acidic function was formally replaced by an oxime or a nitro group and on the other hand the lipophilic substituent was modified. The results of the biol. evaluation of these derivatives permitted to gain insight into structural features critical for the aldose reductase inhibition.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bhuyan, Bhaskar J. published the artcileSynthesis, characterization and antioxidant activity of angiotensin converting enzyme inhibitors, Formula: C4H7BrO2, the publication is Organic & Biomolecular Chemistry (2011), 9(5), 1356-1365, database is CAplus and MEDLINE.

Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I (Ang I) to angiotensin II (Ang II). ACE also cleaves the terminal dipeptide of vasodilating hormone bradykinin (a nonapeptide) to inactivate this hormone. Therefore, inhibition of ACE is generally used as one of the methods for the treatment of hypertension. Oxidative stress’ is another disease state caused by an imbalance in the production of oxidants and antioxidants. A number of studies suggest that hypertension and oxidative stress are interdependent. Therefore, ACE inhibitors having antioxidant property are considered beneficial for the treatment of hypertension. As selenium compounds are known to exhibit better antioxidant behavior than their sulfur analogs, we have synthesized a number of selenium analogs of captopril, an ACE inhibitor used as an antihypertensive drug. The selenium analogs of captopril not only inhibit ACE activity but also effectively scavenge peroxynitrite, a strong oxidant found in vivo.

Organic & Biomolecular Chemistry published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Formula: C4H7BrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Choi, Isaac published the artcileRecyclable Ruthenium Catalyst for Distal meta-C-H Activation, HPLC of Formula: 401-55-8, the publication is Chemistry – A European Journal (2020), 26(66), 15290-15297, database is CAplus and MEDLINE.

The unprecedented hybrid-ruthenium catalysis for distal meta-C-H activation was disclosed. The hybrid-ruthenium catalyst was recyclable, as was proven by various heterogeneity tests, and fully characterized with various microscopic and spectroscopic techniques, highlighting the phys. and chem. stability. Thereby, the hybrid-ruthenium catalysis proved broadly applicable for meta-C-H alkylations of among others purine-based nucleosides and natural product conjugates. Addnl., its versatility was further reflected by meta-C-H activations through visible-light irradiation, as well as para-selective C-H activations.

Chemistry – A European Journal published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ruasse, Marie Francoise published the artcileSolvation and steric effects on electrophilic reactivity of ethylenic compounds. 1. Stereochemistry and bromination of congested adamantylidenealkanes, Category: bromides-buliding-blocks, the publication is Journal of Organic Chemistry (1990), 55(8), 2298-303, database is CAplus.

Rate constants for bromine addition to I (R, R¹ given: H, H; H, Me; H, Et; H, Me₂CH; H, Me₃C; H, neopentyl; Me, Me; Et, Et; Me, Me₂CH; Me₂CH, Me₂CH) were determined in MeOH and in AcOA. The data indicate that solvent effect is markedly smaller than that on linear alkenes, which suggests that greater steric retardation in I can be attributed to mechanistic changes: inhibition of nucleophilic solvent assistance in the ionization step and/or return resulting from a slow product-forming step.

Journal of Organic Chemistry published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Garlock, Edward A. Jr. published the artcileAnthracene series. I. Methyl ketones and carbinolamines derived from 1,2,3,4-tetrahydroanthracene, HPLC of Formula: 52358-73-3, the publication is Journal of the American Chemical Society (1945), 2255-9, database is CAplus and MEDLINE.

Anthracene (I) (89 g.), 5 g. Cu chromite, and 300 cc. decalin, shaken with H at 2300 lb. and 250° for 24 min., give 43% of the 1,2,3,4-tetrahydro derivative (II); reduction at 1500 lb. and 130° gives 25% of II. Reduction of I at 2300 lb. and 150° for 5 min. gives 95% of the 9,10-dihydro derivative AcCl (20.5 cc.) and 60 g. AlCl₃ in 190 cc. PhNO₂ at -3° to -7°, treated slowly with 45.5 g. of II in 145 cc. PhNO₂, with stirring at 5° for 20 h., the resulting oil distilled at 0.1 mm. (160-70°), and crystallized from 200 cc. ligroin, give 17.6 g. of 6-acetyl-1,2,3,4-tetrahydroanthracene (III), m. 101-2°, and, from the mother liquor, 13.5 g. of the 5-isomer (IV), n_D²⁵ 1.6333 (isolated as the semicarbazone, m. 209-11°). III yields a semicarbazone, m. 251.5-2.5°; an oxime, m. 165.5-7°; and a picrate, light yellow, m. 118-20°. III (4.4 g.) in 25 cc. AcOH, treated with 5 g. CrO₃ in 3 cc. H₂O and 22 cc. AcOH at 50°, warmed to 60° for 10 min. and allowed to stand at room temperature for 1 h., gives 2.2 g. of 6-acetyl-1,2,3,4-tetrahydro-9,10-anthraquinone, yellow, m. 169-70°. III (8.96 g.) in 260 cc. EtOH at 5°, treated dropwise with 2.1 cc. Br, gives 8 g. of the 6-(ω-bromoacetyl)derivative (V), light yellow, m. 113.5-15°. III (1.1 g.), reduced with 6.5 cc. of 3 N (iso-PrO)₃Al in iso-PrOH for 15 min., gives 0.9 g. of the 6-(1-hydroxyethyl) derivative, m. 87.5-8.5°. III (2.2 g.), 10 g. amalgamated Zn, 20 cc. AcOH, 20 cc. concentrated HCl, and 8 cc. PhMe, refluxed 24 h. (three 6-cc. portions of concentrated HCl added during this period), give 1.9 g. of 6-ethyl-1,2,3,4-tetrahydroanthracene, m. 38-9.5° (picrate, bright red, m. 100-1°, very unstable). III (3.3 g.), refluxed with alk. NaOCl for 2 h., gives 2.8 g. of 1,2,3,4-tetrahydro-6-anthracenecarboxylic acid, m. 264-6°; Et ester (VI), m. 113°. Dehydrogenation of III gives 2-acetylanthracene and of VI gives Et 2-anthroate. V (6.06 g.) in 50 cc. absolute ether, treated with 6.38 g. Am₂NH, shaken for 3 h., and reduced with 30 cc. 3 N (iso-PrO)₃Al in iso-PrOH, gives 3.5 g. of 6-(2-diamylamino-1-hydroxyethyl)-1,2,3,4-tetrahydroanthracene-HCl, m. 114.5-16°; the diheptylamino homolog m. 114.5-16.5°; the dinonylamino homolog m. 112-16°. IV forms an oxime, m. 120.5-2.5°, and a picrate, light yellow, m. 115-16°. Oxidation of IV with CrO₃ in AcOH gives 5-acetyl-1,2,3,4-tetrahydro-9,10-anthraquinone, light yellow, m. 122-4°. Reduction of IV with (iso-PrO)₃Al in iso-PrOH gives 5-(1-hydroxyethyl)-1,2,3,4-tetrahydroanthracene, m. 73.5-6.5°. Oxidation of IV with NaOCl gives 1,2,3,4-tetrahydro-5-anthracenecarboxylic acid, m. 190-6°; Et ester, m. 64-70°. Dehydrogenation of IV gives 1-acetylanthracene. In the reaction of I and AcCl in C₂H₂Cl₄, the formation of III is almost entirely suppressed and the oily ketone (IV) is formed in approx. the same yield as in the PhNO₂ experiment

Journal of the American Chemical Society published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, HPLC of Formula: 52358-73-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Okuda, Yasuhiro published the artcileIntramolecular cyclization mediated by silylmetalation of acetylenes with dimethylphenylsilylmethylmagnesium (PhMe₂SiMgMe)/cuprous iodide and radical nature of the reagent, Computed Properties of 81216-14-0, the publication is Tetrahedron Letters (1984), 25(23), 2483-6, database is CAplus.

HCC(CH₂)₃XR (X = bond, CH₂, CHMe, CHBu,CH₂CH₂; R = O₃SC₆H₄Me-4, O₃SMe, Br) underwent CuI-catalyzed reaction with Me₂SiPhMgMe to give 25-91% methylenylcycloalkanes I. However, the same treatment of HCCCH₂CHR¹O₃SMe (R¹ = H, Me) gave 30-45% methylenecyclopropanes II and 10-41% silylcyclobutenes III.

Tetrahedron Letters published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Computed Properties of 81216-14-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kajigaeshi, Shoji published the artcileHalogenation using quaternary ammonium polyhalides. Part 22. Selective bromination of aromatic ethers with benzyltrimethylammonium tribromide, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1990), 897-9, database is CAplus.

The reaction of aromatic ethers with a stoichiometric amount of benzyltrimethylammonium tribromide in CH₂Cl₂-MeOH or HOAc-ZnCl₂ under mild conditions gave, selectively, mono-, di-, or tribromo aromatic ethers in quant. yield.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary