Author: Jessica.F

Abdelhafiz, Fatma M. published the artcileDesigning of quaternized hyperbranched polyamidoamines dendrimers: Surface activity, pharmaceutical efficacy, and safety approach, HPLC of Formula: 143-15-7, the publication is Journal of Drug Delivery Science and Technology (2022), 102929, database is CAplus.

The low solubility of the drug considers a major challenge for pharmaceutical formulation of both oral and parenteral products. In this work various generations of cationic hyperbranched polyamidoamine (PAMAM) quaternary ammonium salt dendrimers terminated with amine end groups were synthesized. The pharmaceutical application of these quaternized cationic surfactants ended with amine end groups and those ended with ester end groups which prepared in an earlier study were investigated. These dendrimers were compared as solubilizing agents for coenzyme Q10 (poorly soluble drug) and the dendrimers that showed high solubilizing potential (G_2.5 C₈, G_2.5 C₁₂) were selected to be evaluated as a dendrimer in dissolution study for coenzyme Q10 or Ledipasvir drug. In our investigation a comparison between four dissolution media with different surfactants namely, G_2.5 C₈, G_2.5 C₁₂, CTAB and Labrasol used for the dissolution test of Q10 was carried out. The results revealed that % Q10 released after 4 h was 86.7, 70.5, 43 and 10.5% for these dissolution media, resp. These results indicated the priority of the synthesized cationic surfactants than the known com. cationic surfactant (CTAB) or than Labrasol as recommended surfactant in previous lectures. Therefore, the profiles of the ledipasvir dissolution in the three-dissolution media G_2.5 C₈, G_2.5 C₁₂ and FDA surfactant (1.5% tween 80 and 0.0075 mg/mL Butylated Hydroxytoluene (BHT)) are similar. The obtained results emphasized that the new surfactants can be used as alternative to FDA surfactant in the dissolution media of Ledipasvir. Eventually, the toxicity study was performed for two selected compounds from the prepared dendrimers, and these compounds were proved to be safe.

Journal of Drug Delivery Science and Technology published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, HPLC of Formula: 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Abdelhafiz, Fatma M. published the artcileDesigning of quaternized hyperbranched polyamidoamines dendrimers: Surface activity, pharmaceutical efficacy, and safety approach, Recommanded Product: 1-Bromooctane, the publication is Journal of Drug Delivery Science and Technology (2022), 102929, database is CAplus.

The low solubility of the drug considers a major challenge for pharmaceutical formulation of both oral and parenteral products. In this work various generations of cationic hyperbranched polyamidoamine (PAMAM) quaternary ammonium salt dendrimers terminated with amine end groups were synthesized. The pharmaceutical application of these quaternized cationic surfactants ended with amine end groups and those ended with ester end groups which prepared in an earlier study were investigated. These dendrimers were compared as solubilizing agents for coenzyme Q10 (poorly soluble drug) and the dendrimers that showed high solubilizing potential (G_2.5 C₈, G_2.5 C₁₂) were selected to be evaluated as a dendrimer in dissolution study for coenzyme Q10 or Ledipasvir drug. In our investigation a comparison between four dissolution media with different surfactants namely, G_2.5 C₈, G_2.5 C₁₂, CTAB and Labrasol used for the dissolution test of Q10 was carried out. The results revealed that % Q10 released after 4 h was 86.7, 70.5, 43 and 10.5% for these dissolution media, resp. These results indicated the priority of the synthesized cationic surfactants than the known com. cationic surfactant (CTAB) or than Labrasol as recommended surfactant in previous lectures. Therefore, the profiles of the ledipasvir dissolution in the three-dissolution media G_2.5 C₈, G_2.5 C₁₂ and FDA surfactant (1.5% tween 80 and 0.0075 mg/mL Butylated Hydroxytoluene (BHT)) are similar. The obtained results emphasized that the new surfactants can be used as alternative to FDA surfactant in the dissolution media of Ledipasvir. Eventually, the toxicity study was performed for two selected compounds from the prepared dendrimers, and these compounds were proved to be safe.

Journal of Drug Delivery Science and Technology published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Khudolei, V. V. published the artcileThe study of mutagenic activity of carcinogens and other chemical agents with Salmonella typhimurium assays: testing of 126 compounds, Quality Control of 97845-58-4, the publication is Archiv fuer Geschwulstforschung (1987), 57(6), 453-62, database is CAplus and MEDLINE.

A total of 126 chem. compounds were tested in the Ames assay with S. typhimurium of 8 various strains (mainly TA98 + TA100). For metabolic activation liver S₉ from arochlor-treated rats was used. In the first group of substances tested (51 compounds with confirmed carcinogenicity for animals) 45 agents possessed mutagenicity and 6 gave false-neg. response (1,2-dimethylhydrazine, urethane, DDT, chloroform, carbon tetrachloride, 1,4-dioxane). In group 2 (27 compounds which did not possess carcinogenic activity) 22 agents were correctly identified and the other 5 gave false-pos. responses (acrolein, styrene oxide, acridine orange, 1-naphthylamine, dichloromethane). After summation of data obtained, test sensitivity for both groups together made 88.2%; specificity 81.5% and predictive value 90%. In group 3 (48 compounds, presented by chem., pharmaceutical and food industries, for which either there are insufficient data on their carcinogenicity, or they were tested for the first time), 8 appeared mutagenic (1-aminoanthraquinone, 2-aminoanthraquinone, 1-amino-4-chloroanthraquinone, 2-amino-3-oxyanthraquinone, Rhoduline blue 5B, dinitrochlorbenzene, nitrosodiphenylamine and 2,3,5-trinitronaphthalene).

Archiv fuer Geschwulstforschung published new progress about 97845-58-4. 97845-58-4 belongs to bromides-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Bromide, name is 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane, and the molecular formula is C8H15BrO2, Quality Control of 97845-58-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Matsumoto, Mutsuyoshi published the artcileReversible Light-Induced Morphological Change in Langmuir-Blodgett Films, Recommanded Product: Sodium 3-bromopropane-1-sulfonate, the publication is Journal of the American Chemical Society (1998), 120(7), 1479-1484, database is CAplus.

An amphiphilic anionic azobenzene derivative, soluble in water, formed a monolayer on an aqueous subphase containing a water-soluble polycation. The monolayers were transferred onto solid substrate by the Langmuir-Blodgett (LB) technique. XPS measurements showed that ion exchange reaction proceeded almost completely at the air-water interface and that the ratio of the monomer unit of the polycation to the azobenzene was almost unity. UV/visible absorption and IR measurements indicated that the azobenzene photoisomerized reversibly in the LB films on alternate illumination with UV and visible light. Furthermore, a reversible morphol. change induced by light was observed in the LB films with AFM. Before illumination, the surface of the single-layer LB film was very smooth with a surface undulation of less than 1 nm. On illumination with UV light, however, a number of hills, with the height of ca. 5 nm and the diameter of the base of ca. 100 nm, appeared on the film surface. These structures almost disappeared on illumination with visible light. This indicates that the widely accepted assumption that photoisomerization should not change the two-dimensional structures significantly does not hold in the present case.

Journal of the American Chemical Society published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Recommanded Product: Sodium 3-bromopropane-1-sulfonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Abiru, Toichi published the artcileNucleosides and nucleotides. 107. 2-(Cycloalkylalkynyl)adenosines: adenosine A₂ receptor agonists with potent antihypertensive effects, Safety of (2-Bromoethyl)cyclopentane, the publication is Journal of Medicinal Chemistry (1992), 35(12), 2253-60, database is CAplus and MEDLINE.

Adenosine receptor-binding profiles in rat brain tissues and antihypertensive effects in spontaneously hypertensive rats (SHR) of a series of 2-(cycloalkylalkynyl)adenosines, e.g. I [R = Ph, CH₂CH₂Ph, C(OH)Me₂, cyclopentyl, cyclohexyl], and their congeners are described. MSBAR of this series of compounds I is discussed, focusing on the length of the alkynyl side chain, and bulkiness of the terminal cycloalkyl substituents in terms of binding activity and cardiovascular effects. I had a preferential affinity of for A₂ receptors. Of these derivatives, 2-(3-cyclopenyl-1-propyn-1-yl)adenosine (II) exhibited the most selective affinity for A₂ receptors. In the C-2 binding region of adenosine, compounds often have potent and/or selective A₂ activity from introduction of an acetylenic group at the C-2 position followed by one methylene residue further followed by a hydrophobic substituent such as a cycloalkyl ring at the terminal position of the alkynyl side chain. I.v. injection of II up to 100 μg/kg had a potent hypotensive effect without a marked decrease in heart rate in anesthetized SHR. These compounds caused a marked bradycardia upon i.v. administration in anesthetized SHR. Oral administration of II (0.1-1 mg/kg) had a potent and long-lasting antihypertensive effect in conscious SHR.

Journal of Medicinal Chemistry published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, Safety of (2-Bromoethyl)cyclopentane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yamato, Takehiko published the artcileDirect introduction of bromine onto a bridge methylene of 5,13-di-tert-butyl-8,16-dimethyl[2.2]metacyclophane, SDS of cas: 111865-47-5, the publication is Journal of Chemical Research (2006), 493-495, database is CAplus.

Treatment of 5,13-di-tert-butyl-8,16-dimethyl[2.2]metacyclophane I (R = R¹ = H) with 1,3-dibromo-5,5-dimethylhydantoin in CH₂Cl₂ led to the first successful introduction of bromine onto a bridge methylene group, giving I (R = H, R¹ = Br). This product was dehydrobrominated and was also converted to I (R = H; R¹ = OAc, OH) and I (RR¹ = O).

Journal of Chemical Research published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C8H13N5O, SDS of cas: 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Morino, Yonezo published the artcileDipole moments of 2,3-dihalo-2,3-dimethylbutane, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane, the publication is Bulletin of the Chemical Society of Japan (1955), 165-71, database is CAplus.

cf. C.A. 45, 947i; 48, 13297h. The dipole moments of X(Me)₂CC(Me)₂X [where X = Cl(I) and Br(II)] are 1.24, -; -, 0.88; 1.30, -; -, 0.97; 1.37, 1.03; and 1.47, 1.15 for -20; -15; 0; 6; 25; and 55°, resp., in CCl₄, and 1.74, 1.24 D. at 25° in C₆H₆. These data indicate the existence of a rotational isomer or gauche form with a ΔΕ of 1.1 and 1.3 for I and 1.5 and 1.5 kcal./mole for II in CCl₄ and heptane, resp. The dipole moments of the gauche form are 2.8 and 3.2 for I and 2.6 and 2.6 D. for II in CCl₄ and heptane, resp.

Bulletin of the Chemical Society of Japan published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yokohama, Shuichi published the artcileSynthesis and antiallergy activity of [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives. II. 6-Alkyl- and 6-cycloalkylalkyl derivatives, HPLC of Formula: 18928-94-4, the publication is Chemical & Pharmaceutical Bulletin (1992), 40(9), 2391-8, database is CAplus and MEDLINE.

A series of 6-alkyl- or 6-(cycloalkylalkyl)-[1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-ones, including I (R = cyclopentylethyl, cyclopentylpropyl, cyclohexylmethyl, cyclohexylpropyl, cycloheptylethyl, cyclooctylethyl, cyclododecylethyl), was synthesized from the corresponding 1,3,4-thiadiazol-5-amines II and the antiallergic activities of the products were evaluated. Among these compounds 6-(2-cyclohexylethyl)-[1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one (I, R = cyclohexylethyl), whose x-ray crystallog. stereostructure was determined, is a promising new antiallergic agent, which has low toxicity and dual activity as a leukotriene D₄ receptor antagonist and as an orally active mast cell stabilizer.

Chemical & Pharmaceutical Bulletin published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C9H6N2O2, HPLC of Formula: 18928-94-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nakatsuji, M. published the artcileFerro- and antiferromagnetic interactions of cyano-substituted thioaminyl radicals, SDS of cas: 111865-47-5, the publication is Polyhedron (2001), 20(11-14), 1355-1357, database is CAplus.

Four kinds of thioaminyls, N-(arylthio)-2-ethoxycarbonyl- (1), N-(arylthio)-2-acetyl- (2), N-(arylthio)-2-cyano- (3), and N-(arylthio)-2-fluoro-4,6-diarylphenylaminyls (4) were prepared Thioaminyls 3 were quite persistent and could be isolated as radical crystals. For the isolated three radicals (I, II, and III) the magnetic susceptibility measurements were carried out using a SQUID magnetometer in the temperature range 1.8-300 K The magnetic interactions of II and III were antiferromagnetic, and that of I was ferromagnetic. Anal. of the χ_molT vs. T plots of I with the 1-dimensional regular Heisenberg model gave 2J/k_B=+11.2 K.

Polyhedron published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, SDS of cas: 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Han, Hoon published the artcileDevelopment of a proton exchange membrane based on trifluoromethanesulfonylimide-grafted polybenzimidazole, Name: Sodium 3-bromopropane-1-sulfonate, the publication is Polymer Journal (Tokyo, Japan) (2021), 53(12), 1403-1411, database is CAplus.

Trifluoromethanesulfonylimide-grafted polybenzimidazole (PBI-TFSI) was synthesized for proton exchange membrane (PEM) applications. Its proton conductivity was (a) less dependent on humidity and (b) higher than that of conventional fluorine-based PEM (Nafion) and propanesulfonic acid-grafted PBI (PBI-PS) at a relative humidity of 40%. The chem. structure of PBI-TFSI was investigated using ¹H and ¹⁹F NMR and Fourier transform IR spectroscopy. The membranes exhibited good transparency, flexibility, and thermal stability up to 350 °C. Membranes with different side chain grafting ratios were prepared, and the water uptake and hydration number of the PBI-TFSI membranes were lower than those of the PBI-PS membranes, most likely because of the hydrophobicity of the side chain. The higher proton concentration provided by TFSI with stronger acidity than PS might be the reason for the higher proton conductivities of PBI-TFSI.

Polymer Journal (Tokyo, Japan) published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Name: Sodium 3-bromopropane-1-sulfonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary