Author: Jessica.F

Sweeting, Orville J. published the artcile1,3-Dienes. II. Stereoisomerism of bromides and glycols derived from 2,3-dimethyl-1,3-butadiene, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane, the publication is Journal of the American Chemical Society (1946), 1057-61, database is CAplus.

cf. C.A. 35, 1377.4. (MeC:CH₂)₂ (I) (41 g.) in 200 mL. CHCl₃ at -10°, treated with 80 g. Br in 150 mL. CHCl₃ during 5 h., gives 87% of the trans-1,4-dibromide (II), b₅ 88.5-91.5°, m. 47-7.5°, and small quantities of the cis-isomer (III), b₅ 77.5-9.5°, d₄²⁵ 1.6695, n_D²⁵ 1.5558, n_D⁵⁰ 1.5420, and of the 1,2,3,4-tetrabromide (IV), m. 138.5-9°. I (76 g.) in 200 mL. petr. ether at -5°, treated with 148 g. Br at such a rate that the temperature remained below 0° (7 h.), gives 25.5 g. of IV, 75% of II, and 4% of III. When the reaction of I and Br in CHCl₃ is illuminated with UV light (temperature not above 30°) there result 10% of II and 46% of III; without illumination, 80% of II was formed. Ozonolysis of III gives 75% of BrCH₂Ac; no HCHO was found. II (25 g.), heated under reduced pressure at 120° for 15 h., gives 11.1 g. of III. II (65 g.) and 60 g. AcOK in 550 mL. absolute EtOH, refluxed 10 h., give 67% of trans-1,4-diacetoxy-2,3-dimethyl-2-butene (V), m. 38.5-9°; similarly, III gives 75% of the cis-isomer (VI) of V, b₇ 108-11°, b₂₈ 138-44°. V (5 g.) in 100 mL. CCl₄, treated with 4 g. Br at -10°, gives 17% of the 2,3-di-Br derivative, b₇ 70-2°, which rapidly becomes green and then black; the same compound appears to be formed from VI, and also by stirring 15 g. of IV and 25 g. AcOAg in AcOH for 14 h. IV does not react with AcOK. V (10 g.) and 31.5 g. Ba(OH)₂ in 50 mL. EtOH, refluxed and stirred for 5 h., give 46% of trans-2,3-dimethyl-2-butene-1,4-diol (VII), m. 57-8° (bisphenylurethane, m. 157-7.5°); the cis-isomer (VIII), b₅ 110-15° (bisphenylurethane, m. 147-8°). Pinacol and aqueous HBr give 2,3-dibromo-2,3-dimethylbutane, m. 177-7.5° (sealed tube). The following values for μ × 10¹⁸ are given: II 1.72, III 2.49, IV 1.55, V 1.90, VI 2.58, VII 1.93, VIII 2.52, and trans-1,4-dibromo-2-butene 1.63. The phys. and chem. evidence affords reasonable grounds for assigning the trans-configuration to II, V, and VII. All the evidence is consistent with the view that III is the cis-isomer and that VI and VIII are largely, if not entirely, the cis-isomers.

Journal of the American Chemical Society published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C17H37NO3, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Xiang published the artcileCatalytic remote hydrohalogenation of internal alkenes, Quality Control of 143-15-7, the publication is Nature Chemistry (2022), 14(4), 425-432, database is CAplus and MEDLINE.

Abstract: Primary alkyl halides have broad utility as fine chems. in organic synthesis. The direct halogenation of alkenes is one of the most efficient approaches for the synthesis of these halides. Internal alkenes, in particular mixtures of isomers from refineries, constitute readily available and inexpensive feedstock and are the most attractive starting materials for this synthesis. However, the hydrohalogenation of alkenes generally affords branched alkyl halides; there are no catalytic methods to prepare linear alkyl halides directly from internal alkenes, let alone from a mixture of alkene isomers. Here a report the remote oxidative halogenation of alkenes under palladium catalysis via which both terminal and internal alkenes yield primary alkyl halides efficiently. Engineering pyridine-oxazoline ligands by introducing a hydroxyl group is essential for achieving excellent chemo- and regioselectivity. The catalytic system is also good for the mixture of alkene isomers generated from dehydrogenation of alkanes, providing a window to investigate the high-value utilization of inexpensive alkanes.

Nature Chemistry published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Quality Control of 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Xiaoyi published the artcileNovel fluorescent columnar liquid crystal based on tetraphenylethylene-rufigallol-tetraphenylethylene triads, COA of Formula: C12H25Br, the publication is Journal of Molecular Structure (2022), 132210, database is CAplus.

Two new tetraphenylethylene- rufigallol-tetraphenylethylene triads 7a and 7b were synthesized in yield of 50%. These compounds were characterized by mass spectrometry, NMR spectroscopy, and elemental anal. Their mesomorphic behaviors were studied by polarization microscopy, DSC, and x-ray diffractometry. Study of their liquid crystalline behaviors indicated that 7a and 7b possessed the hexagonal columnar mesophase. 7b with dodecyl chains exhibited the low phase transition temperatures and wide range of mesophase temperatures in comparison with 7a. 7a and 7b exhibited excellent aggregation-induced emission in H₂O/THF solution The fluorescence quantum yields of these compounds in the solid state were 22 and 16%, resp. Results from this study suggest that sym. trimer was a good approach to construct novel fluorescence columnar liquid crystals.

Journal of Molecular Structure published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C65H82N2O18S2, COA of Formula: C12H25Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yuan, Lin published the artcileA highly active and selective chalcogen bond-mediated perchlorate channel, Application of 1-Bromooctane, the publication is Chinese Chemical Letters (2022), 33(4), 2026-2030, database is CAplus.

Artificial membrane transporters that either use chalcogen bonds to facilitate transmembrane flux of anions or show high selectivity toward perchlorate anions are rare. In this work, we report on one such novel monopeptide-based transporter system, featuring both chalcogen bonds for highly efficient anion transport and high transport selectivity toward ClO-4 anions. Structurally, these monopeptide mols. associate with each other via H-bonds to produce H-bonded 1D stack that not only one dimensionally but also directionally aligns the terminal bicyclic thiophene motifs to the same side. Functionally, these well-aligned thiophenes create a sulfur-rich transmembrane pathway, combinatorially fine-tunable to enable anions to efficiently cross the membrane in the increasing activity of Cl- < Br- < NO-3 < ClO-4via chalcogen bonds, with EC50 values of 0.75, 0.40, 0.37 and 0.093 μmol/L (0.3 mol% relative to lipid mols.), resp.

Chinese Chemical Letters published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C9H7NO3, Application of 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lian, Zhe published the artcileSignificant enhancement of light-harvesting efficiency through the formation of [2]pseudorotaxane with γ-cyclodextrin based on a bolaamphiphile of salicylaldehyde azine moiety, Product Details of C13H17BrO3, the publication is Dyes and Pigments (2019), 475-480, database is CAplus.

In this work, we have designed and synthesized a bolaamphiphile of salicylaldehyde azine (BSA), which can form [2]pseudorotaxane with γ-cyclodextrin (BSA@γ-CD) in aqueous solution and exhibit remarkable enhancement of the fluorescence emission. Both BSA and BSA@γ-CD assembly can spontaneously form spherical aggregates in aqueous solution with diameter at about 30 nm and 20 nm, resp. By using BSA and BSA@γ-CD as energy donor and sulforhodamine 101 (SR101) as energy acceptor, we fabricated two artificial light-harvesting systems in aqueous solution Significantly, an efficient energy transfer process was revealed to occur between the BSA or BSA@γ-CD assembly and the loaded SR101 to obtain high energy transfer efficiency and antenna effect. More importantly, energy transfer efficiency and antenna effect can be greatly improved in these two systems only just by addition of γ-CD.

Dyes and Pigments published new progress about 1207448-58-5. 1207448-58-5 belongs to bromides-buliding-blocks, auxiliary class Bromide,Benzene,Phenol,Ether,Aldehyde, name is 4-((6-Bromohexyl)oxy)-2-hydroxybenzaldehyde, and the molecular formula is C13H17BrO3, Product Details of C13H17BrO3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Cavieres, Jenifer published the artcileIonanofluids based on ionic liquid mixtures, a new approach as an alternative material for solar energy storage, Recommanded Product: 1-Bromooctane, the publication is Journal of Molecular Liquids (2022), 118677, database is CAplus.

Hybrid materials based on ionic liquids (ILs) known as Ionanofluids (INFs) have shown exciting improvements in their thermophys. properties compared to their base fluids (BF). Within this group, INFs obtained using mixtures of ionic liquids as BFs have been virtually ignored until now. In this work, INFs composed of two equimolar mixtures of ILs, [Omim][PF₆] + [Odmim][PF₆] and [Omim][PF₆] + [Odmim][BF₄] as base fluids and Multiwalled Carbon Nanotubes (MWCNTs) with weight percentages of 0.04, 0.06, 0.08, and 0.1 wt% were elaborated. Furthermore, the thermophys. properties of our proposed new materials were evaluated and compared to conventional materials currently used in solar energy storage systems. It was shown that the heat capacity (Cp) reaches increases of up to 3.7 and 3.2 times that of nitrated salts and the com. fluid Therminol VP-1, which translates into a 9.4% and 284% higher thermal storage d. (E), resp., and even lower thermal diffusivity (α), which supports the preliminary idea of using these new materials for energy storage.

Journal of Molecular Liquids published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kale, Someshwar B. published the artcileRongalite as a Sulfone Source: Sulfonylation of para-Quinone Methides and Alkyl/allyl Halides, Product Details of C8H17Br, the publication is Chemistry – An Asian Journal (2022), 17(16), e202200408, database is CAplus and MEDLINE.

A one-pot three-component reaction using p-quinone methides, rongalite and alkyl/allyl halides has been described. The corresponding unsym. sulfones were obtained in good yields under mild reaction conditions in the absence of any metal, base or any other additive.

Chemistry – An Asian Journal published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Product Details of C8H17Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mistry, Shailesh N. published the artcile4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M₁ Muscarinic Acetylcholine Receptor, Computed Properties of 76283-09-5, the publication is Journal of Medicinal Chemistry (2016), 59(1), 388-409, database is CAplus and MEDLINE.

Pos. allosteric modulators (PAMs) of the M₁ muscarinic acetylcholine receptor (M₁ mAChR) are a promising strategy for the treatment of the cognitive deficits associated with diseases including Alzheimer’s and schizophrenia. Herein, we report the design, synthesis, and characterization of a novel family of M₁ mAChR PAMs. The most active compounds of the 4-phenylpyridin-2-one series exhibited comparable binding affinity to the reference compound, 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (BQCA), but markedly improved pos. cooperativity with acetylcholine, and retained exquisite selectivity for the M₁ mAChR. Furthermore, the pharmacol. characterization revealed ligands with a diverse range of activities, including modulators that displayed both high intrinsic efficacy and PAM activity, those that showed no detectable agonism but robust PAM activity and ligands that displayed robust allosteric agonism but little modulatory activity. Compound I was found to have the best pharmacol. profile. Thus, the 4-phenylpyridin-2-one scaffold offers an attractive starting point for further lead optimization.

Journal of Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Computed Properties of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Seo, Jin-soo published the artcileNovel inhibitors of prolyl 4-hydroxylase; solid-phase synthesis of 2,2-dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyran derivatives, COA of Formula: C7H5Br2F, the publication is Bulletin of the Korean Chemical Society (2006), 27(6), 909-917, database is CAplus.

2,2-Dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyrans were identified as prolyl 4-hydroxylase inhibitors via a screening process using HSC-T6 and LI 90 cells that express an immortalized rat hepatic stellate cell line and as part of a test of the type I collagen contents employing the ELISA method. A subsequent lead optimization effort based on solid-phase parallel synthesis led to the identification of 2,2-dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyrans as potent inhibitors of prolyl 4-hydroxylase.

Bulletin of the Korean Chemical Society published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C9H8BrF3, COA of Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary