Author: Jessica.F

Photocatalyzed site-selective C(sp³)-H sulfonylation of toluene derivatives and cycloalkanes with inorganic sulfinates was written by Zhang, Shaonan;Cao, Shi;Lin, Yu-Mei;Sha, Liyuan;Lu, Cheng;Gong, Lei. And the article was included in Chinese Journal of Catalysis in 2022.SDS of cas: 57293-19-3 This article mentions the following:

Herein, a convenient and economic approach to site-selective C(sp3)-H sulfonylation via photo-induced HAT catalysis was reported. Employing a conjugated polycyclic quinone as a direct HAT photocatalyst, com. available inorganic sulfinates as the sulfonylation source, copper triflate as an inexpensive oxidant, a variety of toluene derivatives and cycloalkanes were converted into biol. and synthetically interesting sulfone products I [Ar = 4-MeC₆H₄, 4-EtC₆H₄, 4-MeOC₆H₄, etc.; R¹ = H, Me; R² = Me, Et, Ph, etc.; R³ = Ph, Et, i-Pr, etc.], II [R⁴ = cyclopentyl, cyclohexyl, cycloheptyl, etc.] under mild conditions. The mechanistic studies reveal that the reaction sequence involved direct HAT-induced radical formation and a subsequent copper-mediated organometallic process for the C-S bond formation. This method offered an appealing opportunity to furnish high value-added products from abundant hydrocarbon starting materials and inexpensive reagents. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3SDS of cas: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.SDS of cas: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One-Pot Preparation of (NH)-Phenanthridinones and Amide-Functionalized [7]Helicene-like Molecules from Biaryl Dicarboxylic Acids was written by Murai, Takuya;Xing, Yongning;Kurokawa, Mayu;Kuribayashi, Toshifumi;Nikaido, Masanori;Elboray, Elghareeb E.;Hamada, Shohei;Kobayashi, Yusuke;Sasamori, Takahiro;Kawabata, Takeo;Furuta, Takumi. And the article was included in Journal of Organic Chemistry in 2022.Electric Literature of C8H6BrFO2 This article mentions the following:

A one-pot transformation of biaryl dicarboxylic acids to (NH)-phenanthridinone derivatives based on a Curtius rearrangement and subsequent basic hydrolysis was developed. This method is also applicable for the preparation of optically active amide-functionalized [7]helicene-like mols. Furthermore, aza[5]helicene derivatives with a phosphate moiety were isolated as a product of the Curtius rearrangement step in the case of substrates that bear chalcogen atoms. The stereostructures of these products, revealed by X-ray diffraction anal., suggested that chalcogen-bonding and pnictogen-bonding interactions might contribute to their stabilization. The configurational stability of the helicene-like mols. and their chiroptical properties were further investigated. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Electric Literature of C8H6BrFO2).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Electric Literature of C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Magnetic glyconanoparticles for selective lectin separation and purification was written by Oz, Yavuz;Abdouni, Yamin;Yilmaz, Gokhan;Becer, C. Remzi;Sanyal, Amitav. And the article was included in Polymer Chemistry in 2019.Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin This article mentions the following:

A modular platform for the separation and purification of lectins using polymer coated iron oxide nanoparticles is developed. Supramol. host-guest interactions based on an adamantane beta-cyclodextrin (灏?CD) dyad are utilized to modify the polymeric interface. Poly(ethylene glycol) based hydrophilic polymer-coated magnetic iron oxide nanoparticles are fabricated using reversible addition-fragmentation chain transfer polymerization, followed by their chain-end modification to install adamantane groups on the nanoparticle surface. These adamantyl containing nanoparticles could be surface modified using 灏?CDs appended with appropriate ligands for intended applications. In this study, we exploit this supramol. system for the purpose of separation and purification of lectins. Therefore, a polymer-coated magnetic nanoparticle interface was decorated with two types of mannose-containing 灏?CD constructs, a monodisperse heptamannose conjugated CD and a CD-based 7-arm star shaped glycopolymer for selective binding towards the Con A (ConA) lectin. The monodisperse and polydisperse CD derivatives were compared in terms of their efficiency for binding to ConA. It was demonstrated that the polymeric CD construct significantly improved the binding of magnetic nanoparticles and provided an effective system for the separation and purification of ConA from a mixture of ConA and peanut agglutinin (PNA). Moreover, the surface bound isolated protein could be simply regenerated by the addition of competitive ligands such as mannose. Specificity to bind a particular lectin can be tailored by choosing the appropriate sugar based ligand, as demonstrated by the specific capture of PNA using a galactose-containing polymer. The modular nature of functionalization of the nanoparticle interface that is tunable by host-guest chem. affords a universal system that can be easily tailored for the purification of specific proteins from mixtures In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-mediated Intermolecular C-H aminohalogenation of Indoles at Room Temperature was written by Lu, Yuanhui;Zhang, Xiaoxiang;Xiao, Xiaoyu;Huang, Ninghua;Dou, Yadong;Liu, Chenrui;Wei, Wanxing;Zhang, Zhuan;Liang, Taoyuan. And the article was included in Asian Journal of Organic Chemistry in 2022.Electric Literature of C4H4BrNO2 This article mentions the following:

An efficient intermol. C-H aminohalogenation of indoles with azoles and NXS (X=F, Cl, Br, I) was developed to provide 2-azolyl-3-halogenated indoles I [R = H, 6-Me, 5-OMe, etc.; R¹ = 4-Br-1H-pyrazol-1-yl, 4-Cl-1H-pyrazol-1-yl, 4-Br-3,5-(Me)₂-1H-pyrazol-1-yl, etc.; R² = Me, Et, Bn, etc.; R³ = F, Cl, Br, I] in one single operation. In addition, this attractive route for the synthesis of compounds I was of great significance due to the product’s versatile reactivity for further transformations. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Electric Literature of C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lipid composition, fatty acids and sterols in the seaweeds Ulva armoricana, and Solieria chordalis from Brittany (France): an analysis from nutritional, chemotaxonomic, and antiproliferative activity perspectives was written by Kendel, Melha;Wielgosz-Collin, Gaetane;Bertrand, Samuel;Roussakis, Christos;Bourgougnon, Nathalie;Bedoux, Gilles. And the article was included in Marine Drugs in 2015.Electric Literature of C15H29BrO2 This article mentions the following:

Lipids from the proliferative macroalgae Ulva armoricana (Chlorophyta) and Solieria chordalis (Rhodophyta) from Brittany, France, were investigated. The total content of lipids was 2.6% and 3.0% dry weight for U. armoricana and S. chordalis, resp. The main fractions of S. chordalis were neutral lipids (37%) and glycolipids (38%), whereas U. armoricana contained mostly neutral lipids (55%). Polyunsaturated fatty acids (PUFA) represented 29% and 15% of the total lipids in U. armoricana and S. chordalis, resp. In both studied algae, the phospholipids were composed of PUFA for 18%. In addition, PUFA were shown to represent 9% and 4.5% of glycolipids in U. armoricana and S. chordalis, resp. The essential PUFA were 16:4n-3, 18:4n-3, 18:2n-3, 18:2n-6, and 22:6n-3 in U. armoricana, and 20:4n-6 and 20:5n-3 in S. chordalis. It is important to notice that six 2-hydroxy-, three 3-hydroxy-, and two monounsaturated hydroxy fatty acids were also identified and may provide a chemotaxonomic basis for algae. These seaweeds contained interesting compounds such as squalene, 浼?tocopherol, cholest-4-en-3-one and phytosterols. The antiproliferative effect was evaluated in vitro on human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) with an IC₅₀ of 23 娓璯/mL for monogalactosyldiacylglycerols isolated from S. chordalis and 24 娓璯/mL for digalactosyldiacylglycerols from U. armoricana. These results confirm the potentialities of valorization of these two species in the fields of health, nutrition and chemotaxonomy. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Electric Literature of C15H29BrO2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Electric Literature of C15H29BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Polyamine-Functionalized 2閳?Amino-LNA in Oligonucleotides: Facile Synthesis of New Monomers and High-Affinity Binding towards ssDNA and dsDNA was written by Danielsen, Mathias B.;Christensen, Niels Johan;Joergensen, Per T.;Jensen, Knud J.;Wengel, Jesper;Lou, Chenguang. And the article was included in Chemistry – A European Journal in 2021.Recommanded Product: 954-81-4 This article mentions the following:

Attachment of cationic moieties to oligonucleotides (ONs) promises not only to increase the binding affinity of antisense ONs by reducing charge repulsion between the two neg. charged strands of a duplex, but also to augment their in vivo stability against nucleases. In this study, polyamine functionality was introduced into ONs by means of 2閳?amino-LNA scaffolds. The resulting ONs exhibited efficient binding towards ssDNA, ssRNA and dsDNA targets, and the 2閳?amino-LNA analog carrying a tri-aminated linker showed the most pronounced duplex- and triplex-stabilizing effect. Mol. modeling revealed that favorable conformational and electrostatic effects led to salt-bridge formation between pos. charged polyamine moieties and the Watson-Hoogsteen groove of the dsDNA targets, resulting in the observed triplex stabilization. All the investigated monomers showed increased resistance against 3閳?nucleolytic digestion relative to the non-functionalized controls. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Recommanded Product: 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis, Antioxidant, Anti-Inflammatory, and Antimicrobial Screening of Newer Thiophene-Fused Arylpyrazolyl 1,3,4-Oxadiazoles was written by Mahajan, Pravin;Nikam, Mukesh;Chate, Asha;Nimbalkar, Urja;Patil, Vrushali;Bobade, Anil;Chaudhari, Abhay;Deolankar, Dattatray;Javale, Balasaheb;Gill, Charansingh. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2015.Category: bromides-buliding-blocks This article mentions the following:

A series of newer 1,3,4-oxadiazole derivatives containing a thiophene fused with pyrazole moiety of pharmacol. significance have been synthesized. The compounds were characterized by ¹H NMR, IR, and mass spectral techniques. The compounds were screened for their in vitro antioxidant, anti-inflammatory and antimicrobial activities. Several compounds showed significant antioxidant activity. One compound showed good anti-inflammatory activity. One compound showed activity . against bacterial and fungal strains. The synthesis of the target compounds was achieved using 3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid hydrazide as a starting material. The title compounds thus formed included 3-methyl-1-phenyl-5-(5-phenyl-1,3,4-oxadiazol-2-yl)-1H-thieno[2,3-c]pyrazole. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Category: bromides-buliding-blocks).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and anticancer activity of chromone-based analogs of lavendustin A was written by Nam, Dong Hyuk;Lee, Ki Yong;Moon, Chang Sang;Lee, Yong Sup. And the article was included in European Journal of Medicinal Chemistry in 2010.Application of 14425-64-0 This article mentions the following:

Lavendustin A and hormothamnione were reported to exhibit cytotoxic effects on tumor cell lines. In the present studies, a series of chromone-based lavendustin analogs were synthesized as a simplified hybrid of hormothamnione and lavendustin A by the reductive-amination of formyl-chromone with various amines followed by aminoalkylation. Most compounds synthesized showed significantly improved potencies compared to the standard compound lavendustin A against most of cancer cell lines tested indicating that the removal of styryl group enhanced cancer cell growth inhibitory activities. Compound I and II showed the most potent inhibitory activities with GI₅₀ values in the range of 6.01-9.92 娓璯/mL on A-549 and HCT-15 cells. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of Benzylic Alcohols by C-H Oxidation was written by Tanwar, Lalita;Boergel, Jonas;Ritter, Tobias. And the article was included in Journal of the American Chemical Society in 2019.Quality Control of 1-(3-Bromopropyl)-4-methoxybenzene This article mentions the following:

Selective methylene C-H oxidation for the synthesis of alcs. with a broad scope and functional group tolerance is challenging due to the high proclivity for further oxidation of alcs. to ketones. Here, authors report the selective synthesis of benzylic alcs. employing bis(methanesulfonyl) peroxide as an oxidant. Authors attempt to provide a rationale for the selectivity for monooxygenation, which is distinct from previous work; a proton-coupled electron transfer mechanism (PCET) may account for the difference in reactivity. Authors envision that our method will be useful for applications in the discovery of drugs and agrochems. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Quality Control of 1-(3-Bromopropyl)-4-methoxybenzene).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 1-(3-Bromopropyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists was written by Shi, Jun;Gu, Zhengxiang;Jurica, Elizabeth Anne;Wu, Ximao;Haque, Lauren E.;Williams, Kristin N.;Hernandez, Andres S.;Hong, Zhenqiu;Gao, Qi;Dabros, Marta;Davulcu, Akin H.;Mathur, Arvind;Rampulla, Richard A.;Gupta, Arun Kumar;Jayaram, Ramya;Apedo, Atsu;Moore, Douglas B.;Liu, Heng;Kunselman, Lori K.;Brady, Edward J.;Wilkes, Jason J.;Zinker, Bradley A.;Cai, Hong;Shu, Yue-Zhong;Sun, Qin;Dierks, Elizabeth A.;Foster, Kimberly A.;Xu, Carrie;Wang, Tao;Panemangalore, Reshma;Cvijic, Mary Ellen;Xie, Chunshan;Cao, Gary G.;Zhou, Min;Krupinski, John;Whaley, Jean M.;Robl, Jeffrey A.;Ewing, William R.;Ellsworth, Bruce Alan. And the article was included in Journal of Medicinal Chemistry in 2018.Electric Literature of C7H6BrF This article mentions the following:

G protein-coupled receptor 40 (GPR40) has become an attractive target for the treatment of diabetes since it was shown clin. to promote glucose-stimulated insulin secretion. Herein, we report our efforts to develop highly selective and potent GPR40 agonists with a dual mechanism of action, promoting both glucose-dependent insulin and incretin secretion. Employing strategies to increase polarity and the ratio of sp³/sp² character of the chemotype, we identified BMS-986118 (compound I), which showed potent and selective GPR40 agonist activity in vitro. In vivo, compound I demonstrated insulinotropic efficacy and GLP-1 secretory effects resulting in improved glucose control in acute animal models. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Electric Literature of C7H6BrF).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Electric Literature of C7H6BrF

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary