Author: Jessica.F

Cho, Yongjoon published the artcileDithienogermole-Based Nonfullerene Acceptors: Roles of the Side-Chains′ Direction and Development of Green-Tinted Efficient Semitransparent Organic Solar Cells, Safety of 2-Bromo-3-(2-ethylhexyl)thiophene, the publication is ACS Applied Energy Materials (2020), 3(8), 7689-7698, database is CAplus.

Inspired by the encouraging properties of Ge-fused heterocyclic dithienogermole (DTG) in optoelectronic applications, we here report two narrow-bandgap acceptor-donor′-donor-donor′-acceptor (A-D′-D-D′-A)-type isomeric nonfullerene acceptors based on DTG (DTG-IW with inward-facing side chains vs DTG-OW with outward-facing side chains) for use in organic solar cells (OSCs). The introduction of the inward-facing side chains into the backbone results in extremely confined face-on crystallites in the solid state, as verified by grazing-incidence wide-angle X-ray scattering measurements. This result is attributed mainly to a better power conversion efficiency (PCE) of 9.16% in the OSC based on a blend of DTG-IW with a narrow-bandgap PTB7-Th donor polymer, as compared with the corresponding DTG-OW-based one. Furthermore, the appealing feature of the blend mixing of the narrow-bandgap donor and acceptor pair is that it enables the construction of a green-tinted efficient semitransparent OSC with a PCE of 6.19% and transmittance of 50.4% in the green wavelength region through incorporation of the recently formulated semitransparent Ag/Sb₂O₃/Ag electrode. Overall, in addition to providing useful perspectives into the side-chain engineering of nonfullerene acceptors, this work highlights that OSC based on the A-D′-D-D′-A-type DTG is a promising narrow-bandgap acceptor for further improvement of the performance of semitransparent OSCs.

ACS Applied Energy Materials published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C12H19BrS, Safety of 2-Bromo-3-(2-ethylhexyl)thiophene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Huan published the artcileSynthesis and Evaluation of 1,2,4-Triazolo[1,5-a]pyrimidines as Antibacterial Agents Against Enterococcus faecium, HPLC of Formula: 21101-63-3, the publication is Journal of Medicinal Chemistry (2015), 58(10), 4194-4203, database is CAplus and MEDLINE.

Rapid emergence of antibiotic resistance is one of the most challenging global public health concerns. In particular, vancomycin-resistant Enterococcus faecium infections have been increasing in frequency, representing 25% of enterococci infections in intensive care units. A novel class of 1,2,4-triazolo[1,5-a]pyrimidines, e.g., I [R¹ = C₆H₄R’, 2-thienyl, 3-thienyl, 2-furyl, 2-pyrrolyl, 2-imiazolyl, 3-indolyl, 3-pyridyl, 2-methoxy-3-pyridyl, 4-pyridyl, cyclohexyl; R’ = i-Pr-4, H, Me-4, Et-4, i-Bu-4, OH-4, OMe-4, OH-3-OMe-4, (OMe)₂-3,4, O(Pr-i)-4, OCF₃-4, SMe-4, etc.], II [R¹ = C₆H₄NMe₂-4, R² = OEt,NHMe, R³ = SCH₂Ph; R¹ = 2-thienyl, R² = OEt, R³ = SCH₂C₆H₄CO₂H-4], III [R¹ = C₆H₄NMe₂-4, R³ = SCH₂Ph; R¹ = C₆H₄OMe-4, C₆H₄OEt-2, R³ = SCH₂C₆H₄CO₂H-4; R¹ = C₆H₃(OMe)₂-3,4, R³ = CH₂C₆H₄F-4; R¹ = C₆H₄Cl-4, R³ = SCH₂-(2-naphthyl)],. IV [R¹ = C₆H₄NMe₂-4, R² = H, R³ = SCH₂Ph; R¹ = C₆H₄Me-4, R² = H, R³ = SCH₂C₆H₄Me-2; R¹ = C₆H₄Me-4, R² = Me-2, Me₂-2,4, R³ = SCH₂C₆H₄Me-3; R¹ = C₆H₄Et-4, R² = H, Me-2, R³ = SCH₂C₆H₄OMe-3; etc.], V [R³ = H, NH₂, CO₂Me, CO₂Et, SMe, SCH₂CONH₂, SCH₂CO₂Et, SCH₂CH₂NHCO₂CH₂Ph, SCH₂-(4-pyridyl), S(2-pyridyl), SCH₂C₆H₄R”-4; R” = Me, OMe, SMe, CF₃, OCF₃, SCF₃, NO₂, CN, CO₂H, CO₂Me] and VI [R¹ = 2-thienyl, R³ = H; R¹ = C₆H₄CHMe₂-4, C₆H₄CO₂H-4, R³ = SCH₂CH₂NHCO₂CH₂Ph], active against E. faecium is reported herein. We used a three-component Biginelli-like heterocyclization reaction for the synthesis of a series of these derivatives based on reactions of aldehydes, β-dicarbonyl compounds, and 3-alkylthio-5-amino-1,2,4-triazoles. The resulting compounds were assayed for antimicrobial activity against the ESKAPE panel of bacteria, followed by investigation of their in vitro activities. These analyses identified a subset of 1,2,4-triazolo[1,5-a]pyrimidines that had good narrow-spectrum antibacterial activity against E. faecium and exhibited metabolic stability with low intrinsic clearance. Macromol. synthesis assays revealed cell-wall biosynthesis as the target of these antibiotics.

Journal of Medicinal Chemistry published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C8H5F3O3, HPLC of Formula: 21101-63-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kim, Heejin published the artcileIntegrated One-Flow Synthesis of Heterocyclic Thioquinazolinones through Serial Microreactions with Two Organolithium Intermediates, Name: (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, the publication is Angewandte Chemie, International Edition (2015), 54(6), 1877-1880, database is CAplus and MEDLINE.

An integrated microfluidic synthesis of a biol. active thioquinazolinone library was presented. Generation of o-lithiophenyl isothiocyanate and subsequent reaction with aryl isocyanates was optimized by controlling the residence time in the microreactor to 16 ms at room temperature S-Benzylic thioquinazolinone derivatives I (R¹ = H, F, OMe, NO₂, Cl, R² = H; R¹ = H, R² = F, Cl, OCF₃, SCF₃) were synthesized within 10 s in high yields (75-98 %) at room temperature These three-step reactions involved two organolithium intermediates, an isothiocyanate-functionalized aryllithium intermediate, and a subsequent lithium thiolate intermediate. The gram-scale synthesis of a multifunctionalized thioquinazolinone in the microfluidic device with a high yield (91 %) and productivity (1.25 g in 5 min) was also described.

Angewandte Chemie, International Edition published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C8H6BrF3S, Name: (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Raphael Karikachery, Alice published the artcileHigh Quantum Yield Molecular Bromine Photoelimination from Mononuclear Platinum(IV) Complexes, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane, the publication is Inorganic Chemistry (2013), 52(7), 4113-4119, database is CAplus and MEDLINE.

Pt(IV) complexes trans-Pt(PEt₃)₂(R)(Br)₃ (R = Br, aryl and polycyclic aromatic fragments) photoeliminate mol. bromine with quantum yields as high as 82%. Photoelimination occurs both in the solid state and in solution Calorimetry measurements and DFT calculations (PMe₃ analogs) indicate endothermic and endergonic photoeliminations with free energies from 2 to 22 kcal/mol of Br₂. Solution trapping experiments with high concentrations of 2,3-dimethyl-2-butene suggest a radical-like excited state precursor to bromine elimination.

Inorganic Chemistry published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Moon, Yejin published the artcileLight-Insensitive Organic Field-Effect Transistors with n-Type Conjugated Polymers Containing Dinitrothiophene Units, Recommanded Product: 2,5-Dibromo-3,4-dinitrothiophene, the publication is Advanced Electronic Materials (2018), 4(11), n/a, database is CAplus.

Here, it is reported that organic field-effect transistors (OFETs) with n-type conjugated polymer, poly[{2,5-bis-(2-octhyldodecyl)-3,6-bis-(thien-2-yl)-pyrrolo[3,4-c]pyrrole-1,4-diyl}-co-{2,2′-(3,4-dinitrothiophene)]-5,5′-diyl}] (PODTPPD-DNT), can be operated without large disturbance by surrounding light. The PODTPPD-DNT polymer synthesized via the Stille coupling reaction could act as a channel layer for n-channel OFETs. Although the PODTPPD-DNT polymer shows a broad optical absorption from UV to near-IR parts up to 1000 nm, the OFETs with the PODTPPD-DNT channel layers do not almost respond to monochromatic (520 and 780 nm) and white light. The reason is assigned to the exciton quenching effect by two nitro groups in the polymer chain. The semitransparent OFETs with the 20 nm thick PODTPPD-DNT channel layers are also almost light-insensitive for operation under typical room light conditions.

Advanced Electronic Materials published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Recommanded Product: 2,5-Dibromo-3,4-dinitrothiophene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nam, Doo H. published the artcileAn improved synthesis of captopril, Safety of 3-Bromo-2-methylpropanoic acid, the publication is Journal of Pharmaceutical Sciences (1984), 73(12), 1843-4, database is CAplus and MEDLINE.

An improved synthesis of captopril using methacrylic acid as the starting material is described. Treatment of methacrylic acid with a hydrogen halide gave the 3-halogneo-2-methylpropanoic acids, which were treated with SOCl₂ to yield the corresponding 3-halogeno-2-methylpropanoyl chlorides. Treatment of the chlorides with L-proline yielded the N-(R,S-3-halogeno-2-methylpropanoyl)-L-prolines (I, R = Br, Cl) (II) which were separated into optically pure R– and S-diastereoisomers using dicyclohexylamine. Treatment of (R)-II with methanolic NH₄SH gave captopril (I, R = SH).

Journal of Pharmaceutical Sciences published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Safety of 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Miclotte, Matthieu P. J. published the artcileTuning the Cloud-Point and Flocculation Temperature of Poly(2-(diethylamino)ethyl methacrylate)-Based Nanoparticles via a Postpolymerization Betainization Approach, Synthetic Route of 55788-44-8, the publication is ACS Polymers Au (2021), 1(1), 47-58, database is CAplus and MEDLINE.

The ability to tune the behavior of temperature-responsive polymers and self-assembled nanostructures has attracted significant interest in recent years, particularly in regard to their use in biotechnol. applications. Herein, well-defined poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA)-based core-shell particles were prepared by RAFT-mediated emulsion polymerization, which displayed a lower-critical solution temperature (LCST) phase transition in aqueous media. The tertiary amine groups of PDEAEMA units were then utilized as functional handles to modify the core-forming block chem. via a postpolymn. betainization approach for tuning both the cloud-point temperature (T_CP) and flocculation temperature (T_CFT) of these particles. In particular, four different sulfonate salts were explored aiming to investigate the effect of the carbon chain length and the presence of hydroxyl functionalities alongside the carbon spacer on the particle’s thermoresponsiveness. In all cases, it was possible to regulate both T_CP and T_CFT of these nanoparticles upon varying the degree of betainization. Although T_CP was found to be dependent on the type of betainization reagent utilized, it only significantly increased for particles betainized using sodium 3-chloro-2-hydroxy-1-propanesulfonate, while varying the aliphatic chain length of the sulfobetaine only provided limited temperature variation. In comparison, the onset of flocculation for betainized particles varied over a much broader temperature range when varying the degree of betainization with no real correlation identified between T_CFT and the sulfobetaine structure. Moreover, exptl. results were shown to partially correlate to computational oligomer hydrophobicity calculations Overall, the innovative postpolymn. betainization approach utilizing various sulfonate salts reported herein provides a straightforward methodol. for modifying the thermoresponsive behavior of soft polymeric particles with potential applications in drug delivery, sensing, and oil/lubricant viscosity modification.

ACS Polymers Au published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Synthetic Route of 55788-44-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wiskur, Sheryl L. published the artcilepK_a Values and Geometries of Secondary and Tertiary Amines Complexed to Boronic Acids-Implications for Sensor Design, Synthetic Route of 166821-88-1, the publication is Organic Letters (2001), 3(9), 1311-1314, database is CAplus and MEDLINE.

The pK_a values and the geometries of secondary and tertiary amines adjacent to boronic acids (e.g. 2-(PhCH₂NRCH₂)C₆H₄B(OH)₂; R = H, Me) were determined using potentiometric and ¹¹B NMR titrations The studies showed that the secondary ammonium ion has a pK_a similar to that of the tertiary ammonium species, which gives tetrahedral B centers at pH values ≳5.5. Therefore, secondary amines as well as tertiary amines, when placed proximal to B centers, can be used to create tetrahedral boronic acids at neutral pH for diol complexation. The mol. structure of 2,6-(2-(2-((HO)₂B)C₆H₄CH₂NHCH₂)-4-pyrimidinyl)₂pyridine was determined by x-ray crystallog.

Organic Letters published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C8H8O3, Synthetic Route of 166821-88-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Motornov, Vladimir published the artcileCopper(I)-Catalyzed Regioselective Chan-Lam N2-Vinylation of 1,2,3-Triazoles and Tetrazoles, Formula: C30H24BrCuN2P, the publication is Advanced Synthesis & Catalysis (2019), 361(14), 3306-3311, database is CAplus.

Copper-catalyzed coupling of π-deficient NH-azoles with vinylboronic acids or vinyltrifluoroborate salt provided a direct route to N2-vinyl-1,2,3-triazoles and N2-vinyltetrazoles. The coupling reaction was efficiently catalyzed by (phen)Cu(PPh₃)Br with low catalyst loading (5 mol%) under base-free conditions. The method was applicable for vinylation of unsubstituted, monosubstituted and disubstituted 1,2,3-triazoles with various functionalities with high N2-selectivity.

Advanced Synthesis & Catalysis published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Formula: C30H24BrCuN2P.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dickner, Tim published the artcileStereoselective synthesis and binding properties of novel concave-shaped indolizino[3,4-b]quinolines, Product Details of C7H13BrSi, the publication is Journal fuer Praktische Chemie (Weinheim, Germany) (2000), 342(8), 804-811, database is CAplus.

Novel all-cis-configurated indolizino[3,4-b]quinoline receptors I [R = Me, R¹ = H, Ph(CH₂)₃O; R² = H, PhNHCO] were prepared via diastereoselective Lewis acid-catalyzed cyclization of N-arylimines II as a key step. In order to obtain the indolizino[3,4-b]quinoline I (R = R² = H; R¹ = Cl), an N-arylimine precursor II (III; R = Me₃Si; R¹ = Cl; R² = H) was prepared in 8 steps from L-prolinol. In contrast to the known β-effect of silyl groups, cyclization of III proceeded via α-carbenium ion species to give the diastereomeric products I (R = Me₃Si; R¹ = Cl; R² = H), which were desilylated to I (R = R² = H; R¹ = Cl). The association constants for receptors I decreased in the order I (R = R² = H; R¹ = Cl) > I (R = Me; R¹ = R² = H) > I (R= Me; R¹ = H; R² = PhNHCO) > I [R = Me; R¹ = Ph(CH₂)₃O; R² = H] for both acetic acid and N-Z-phenylalanine as substrates.

Journal fuer Praktische Chemie (Weinheim, Germany) published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Product Details of C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary