Author: Jessica.F

Mansour, Mounir published the artcileActivation of aryl halides by Cu⁰/1,10-phenanthroline: Cu⁰ as precursor of Cu^I catalyst in cross-coupling reactions, Quality Control of 25753-84-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2008), 6051-6053, database is CAplus and MEDLINE.

The activation of aryl iodides and bromides by Cu⁰/1,10-phenanthroline in acetonitrile (S) generates Cu^I(phenanthroline)S₂⁺ which can be a catalyst for cross-coupling reactions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Quality Control of 25753-84-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Shaohui published the artcileEffect of Decarboxylation on the Photoinitiation Behavior of Nitrocarbazole-Based Oxime Esters, Computed Properties of 143-15-7, the publication is Macromolecules (Washington, DC, United States) (2022), 55(7), 2475-2485, database is CAplus.

A series of 50 oxime esters bearing various substituents were designed and synthesized as photoinitiators (48 of them were never synthesized before and only B1 and B10 were reported). Good light absorption properties in the visible range were observed for these oxime esters. Some structures exhibited better photoinitiation abilities than diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (TPO) upon exposure to a LED@405 nm. Interestingly, PIs with Me substituent on the oxime ester group have better photoinitiation performance than the others. Substituent effects were investigated through MOs calculations, the detection of CO₂, and the investigation of the generated free radicals. The results demonstrate that the substituents on the oxime ester group exert major effects on the photoinitiation ability via the decarboxylation reaction. In addition, a chem. mechanism was proposed. 3D printed objects were successfully obtained by using the most reactive oxime ester as photoinitiator, and their thermal initiation behaviors of several oxime esters were also studied (dual thermal/photochem. initiator behavior).

Macromolecules (Washington, DC, United States) published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Computed Properties of 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Grollier, Kevin published the artcileElectrochemical Trifluoromethylselenolation of Activated Alkyl Halides, Recommanded Product: 1-Bromododecane, the publication is European Journal of Organic Chemistry (2022), 2022(19), e202200123, database is CAplus.

A practical electrochem. method for the generation of CF₃Se^– anion from a shelf-stable reagent (TsSeCF₃) is reported allowing the metal-free trifluoromethylselenolation of activated alkyl halides RCH₂X (X = Br, Cl; R = 4-F-Ph, pyridin-2-yl, 5-nitrofuran-2-yl, undecyl, etc.). Trifluoromethylselenolated compounds RCH₂SeCF₃ have been obtained in modest to excellent yields under the optimized reaction conditions. Finally, cyclic voltammetric and ¹⁹F NMR studies are presented and allowed to gain insight into the reaction mechanism.

European Journal of Organic Chemistry published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Recommanded Product: 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kolycheva, M. T. published the artcileFluorinated benzaldehydes in Leuckart and Rodionov reactions, Computed Properties of 21101-63-3, the publication is Zhurnal Organicheskoi Khimii (1989), 25(11), 2367-72, database is CAplus.

Difluoromethylating RCOR¹ [I; R = 2-HOC₆H₄, R¹ = Me; R = 3,4-(HO)₂C₆H₃, R¹ = H] with ClCHF₂ in Me₂CHOH containing KOH at 70° gave 27-82% I [R = 2-CHF₂OC₆H₄, 3,4-(CHF₂O)₂C₆H₃; same R¹]. These and I (R = 2-CF₃C₆H₄, 2- and 4-CHF₂OC₆H₄; R¹ = H) reacted with HCONH₂ at 150-180° to give 57-82% RCHR¹NHCHO, which were hydrolyzed with concentrated HCl in MeOH to give 25-86% RCHR¹NH₂.HCl (II), and reduced with LiAlH₄ in THF to give 30-52% RCH₂NHMe.HCl (R = 4-CHF₂OC₆H₄, 2-CF₃C₆H₄). RCH₂Br (R = 4-CF₃SC₆H₄, 4-C₂F₅OC₆H₄) reacted with urotropine in CHCl₃ and then with aqueous-alc. HCl to give the corresponding II in 25-74% yield. RCHO (R = 2- and 4-CHF₂OC₆H₄) condensed with CH₂(CO₂H)₂ in EtOH containing NH₄OAc to give 40-52% RCH(NH₂)CH₂CO₂H and 18-35% RCH:CHCO₂H. Analogous treatment of PhCOCF₃ gave 56% CF₃CPh(OH)CH₂CO₂H.

Zhurnal Organicheskoi Khimii published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C8H6BrF3S, Computed Properties of 21101-63-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Li-Jun published the artcileSynthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents, Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(10), 3473-3479, database is CAplus and MEDLINE.

Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds I (R = 4-iodobenzyl), I (R = 4-(trifluoromethyl)benzyl), I (R = 4-nitrobenzyl), I (R = (2-methylthiazol-4-yl)methyl) exhibited significantly inhibitory activities against HBV DNA replication with IC₅₀ values of 5.71, 5.36, 8.90 and 9.08 μM, resp. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.

Bioorganic & Medicinal Chemistry Letters published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C17H18N3NaO3S, Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Suchaud, Virginie published the artcileIdentification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors, Product Details of C7H8BBrO3, the publication is Bioorganic & Medicinal Chemistry (2013), 21(14), 4102-4111, database is CAplus and MEDLINE.

New 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles were prepared and evaluated for their Pim kinase inhibitory potencies as well as their antiproliferative activities toward two prostatic cancer cell lines. Pyrazolocarbazole I was found to be a potent Pim kinase modulator with inhibitory potency toward the three isoforms. Compound II strongly inhibited Pim-3 with weaker effects toward Pim-1 and Pim-2, and thus could be used as an interesting mol. tool to study Pim-3 biol. functions.

Bioorganic & Medicinal Chemistry published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C13H17BrO3, Product Details of C7H8BBrO3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Galli, Diana published the artcileSuppressing the Surface Recombination and Tuning the Open-Circuit Voltage of Polymer/Fullerene Solar Cells by Implementing an Aggregative Ternary Compound, Safety of 2,5-Dibromo-3,4-dinitrothiophene, the publication is ACS Applied Materials & Interfaces (2018), 10(34), 28803-28811, database is CAplus and MEDLINE.

The authors present a novel small mol. based on dithienylthienothiadiazole units (named SM1) acting as an efficient component in ternary blend organic solar cells to modify the hole extraction at the interface. The SM1 suppresses the surface recombination and enhances the open-circuit voltage (V_oc). By introducing SM1 in a host system composed of poly(3-hexylthiophene) (P3HT) and [6,6]-phenyl-C₆₁-butyric acid Me ester (PCBM), the authors obtained V_oc values of up to 0.75 V and fill factors larger than 70% for the ternary blends. As a consequence, the power conversion efficiency is improved by ∼30% compared to P3HT:PCBM binary devices. External quantum efficiency and absorption spectra in the near-IR region do not show any contribution of SM1 in dried films. Instead, the addition of the small mol. improves the V_oc by reducing the surface recombination losses. To shed light on the recombination processes, the authors carried out Fourier-transform photocurrent spectroscopy and impedance spectroscopy measurements. The ternary concept can also have functionalities other than photosensitization and can even act as a morphol.-directing agent or an interface modifier.

ACS Applied Materials & Interfaces published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Safety of 2,5-Dibromo-3,4-dinitrothiophene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wroblewska, Elwira Katarzyna published the artcile5-(3-Bromo-4-hydroxy-5-methoxyphenyl)-7,7-dimethyl-7H-indolo[1,2-a]quinolinium perchlorate as a new indicator for anionic surface active agents determination. Part II. Influence of pH on the titration results, Application of Dimidium bromide, the publication is Tenside, Surfactants, Detergents (2011), 48(2), 127-129, database is CAplus.

The work refers to the already published modification of widely used method for anionic active agents determination which concerns the replacement of the mixed indicator, consisting of Acid Blue 1 and carcinogenic Dimidium Bromide, applied in the International Standard ISO 2271:1989 with solvatochromic dye, i.e. 5-(3-bromo-4-hydroxy-5-methoxyphenyl)-7,7-dimethyl-7H-indolo[1,2-a]quinolinium perchlorate (1). The value of pK_a for examined dye (1) amounts to 6.59, and the effect of pH of the probes on the anal. results was studied, i.e. precision of determination of titration endpoint. The change of pH for aqueous and apparent pH for organic phase were determined during the titration process. It was shown that there was no effect of the pH change in the range from 3.5 to 5.0 on the results. The modification of the method for the probes which pH do not fit to the above range is presented.

Tenside, Surfactants, Detergents published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C9H21NO3, Application of Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wroblewska, E. K. published the artcile5-(3-bromo-4-hydroxy-5-methoxyphenyl)-7,7-dimethyl-7H-indolo[1,2-a] quinolinium perchlorate as a new indicator for anionic surface active agents determination, Synthetic Route of 518-67-2, the publication is Tenside, Surfactants, Detergents (2010), 47(2), 119-122, database is CAplus.

5-(3-Bromo-4-hydroxy-5-methoxyphenyl)-7,7-dimethyl-7H-indolo[1,2-a]quinolinium perchlorate (la) was used as an indicator for anionic surface active agents determination in the manual direct two-phase titration according to the International Standard [ISO 2271: 1989] Surface active agents. The solvatochromic dye (la) can successfully replace the recommended mixed indicator consisting of a mixture of Acid Blue I and carcinogenic dimidium bromide. The detection of the titration endpoint with use of this dye turned out much easier than with the use of the mixed indicator. The procedure was also modified replacing carcinogenic and mutagenic chloroform with less toxic dichloromethane. The concentrations of the anionic surface – active substances in few com. available products were determined using modified two-phase titration method.

Tenside, Surfactants, Detergents published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C22H12F6O6S2, Synthetic Route of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Blake, Matthew R. published the artcileSmall Molecules Targeting PTPσ-Trk Interactions Promote Sympathetic Nerve Regeneration, Category: bromides-buliding-blocks, the publication is ACS Chemical Neuroscience (2022), 13(5), 688-699, database is CAplus and MEDLINE.

Chondroitin sulfate proteoglycans (CSPGs) prevent sympathetic nerve regeneration in the heart after myocardial infarction and prevent central nerve regrowth after traumatic brain injury and spinal cord injury. Currently, there are no small-mol. therapeutics to promote nerve regeneration through CSPG-containing scars. CSPGs bind to monomers of receptor protein tyrosine phosphatase sigma (PTPσ) on the surface of neurons, enhancing the ability of PTPσ to bind and dephosphorylate tropomyosin receptor kinases (Trks), inhibiting their activity and preventing axon outgrowth. Targeting PTPσ-Trk interactions is thus a potential therapeutic target. Here, we describe the development and synthesis of small mols. (HJ-01 and HJ-02) that disrupt PTPσ interactions with Trks, enhance Trk signaling, and promote sympathetic nerve regeneration over CSPGs.

ACS Chemical Neuroscience published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary