Author: Jessica.F

Lanzi, Matteo published the artcileCyclic Diaryl λ³-Bromanes as Original Aryne Precursors, Name: 2-Bromo-5-methoxybenzene boronic acid, the publication is Angewandte Chemie, International Edition (2021), 60(27), 14852-14857, database is CAplus and MEDLINE.

Despite the widespread application of hypervalent iodines, the corresponding λ³-bromanes are less explored. Herein the authors report a general, safe, and high-yielding strategy to access cyclic diaryl λ³-bromanes. These unique compounds feature reactivity that is appealing and complementary to that of λ³-iodanes, generating arynes under mild reaction conditions and in the presence of a weak base. Accordingly, formal meta-selective transition-metal-free C-O and C-N couplings may be achieved. Mechanistic studies unambiguously support the aryne generation mechanism.

Angewandte Chemie, International Edition published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Name: 2-Bromo-5-methoxybenzene boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dey, Madhudeepa published the artcileSynthesis of quaternary ammonium tribromides. A novel green approach, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Green Chemistry Letters and Reviews (2012), 5(4), 639-642, database is CAplus.

Potassium permanganate (KMnO₄) oxidizes quaternary ammonium bromides to the corresponding tribromides conveniently and effectively. The procedure carried out solvent-free and adopted as environmentally friendly. High purity, excellent yield, shorter reaction time and mild reaction conditions are some of the advantages of this synthetic protocol. The efficacy of quaternary ammonium tribromides, especially benzyltrimethylammonium tribromide, was also studied for bromination of some organic substrates.

Green Chemistry Letters and Reviews published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dey, Madhudeepa published the artcileNovel method of synthesis of quaternary ammonium tribromides and investigation of catalytic role of benzyltrimethylammonium tribromide in oxidation of alcohols to carbonyl compounds, Application In Synthesis of 111865-47-5, the publication is Synthetic Communications (2013), 43(12), 1734-1742, database is CAplus.

Stable crystalline organic quaternary ammonium tribromides (QATBs) were easily synthesized by the oxidation of the corresponding organic ammonium bromides (QABs) with ammonium persulfate. The reactions were performed under solvent-free conditions in presence of sulfuric acid and silica as supporting agent. Two equivalents of potassium bromide were used as the source of addnl. bromides for quant. conversion of QABs to QATBs. Ammonium persulfate, a cheap and readily available oxidant carries out the bromide oxidation to tribromide very effectively under solvent-free conditions. The synthesized QATBs catalyzed the oxidation of alcs. to carbonyl compounds with hydrogen peroxide as oxidant in high yields under mild reaction conditions.

Synthetic Communications published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Application In Synthesis of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dey, Madhudeepa published the artcileSodium hypochlorite-promoted novel synthesis of organic ammonium tribromides and application of phenanthroline hydrotribromide in chemoselective oxidation of organic sulfides by hydrogen peroxide, Computed Properties of 111865-47-5, the publication is Chemistry Letters (2014), 43(5), 631-633, database is CAplus.

A novel method of synthesis of organic ammonium tribromides (OATBs) is developed by using an inexpensive and eco-friendly sodium hypochlorite as oxidant for conversion of Br^– to Br₃^–. The OATBs thus prepared include both quaternary ammonium tribromides and N-heterocyclic tribromides. A new addition to the family of OATBs is made in the form of phenanthroline hydrotribromide. The efficacy of this new tribromide as catalyst is ascertained in the oxidative transformation of organic sulfides to their corresponding sulfoxides and sulfones by hydrogen peroxide.

Chemistry Letters published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Computed Properties of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Shi, Zhi-Cai published the artcileModulation of Peripheral Serotonin Levels by Novel Tryptophan Hydroxylase Inhibitors for the Potential Treatment of Functional Gastrointestinal Disorders, Category: bromides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2008), 51(13), 3684-3687, database is CAplus and MEDLINE.

The discovery of a novel class of peripheral tryptophan hydroxylase (TPH) inhibitors is described. This class of TPH inhibitors exhibits excellent potency in in vitro biochem. and cell-based assays, and it selectively reduces serotonin levels in the murine intestine after oral administration without affecting levels in the brain. These TPH1 inhibitors may provide novel treatments for gastrointestinal disorders associated with dysregulation of the serotonergic system, such as chemotherapy-induced emesis and irritable bowel syndrome.

Journal of Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C15H14Cl2S2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Teichmann, Marcus published the artcileBromination of 1,5-anhydrohex-1-enitols (glycals) using quaternary ammonium tribromides as bromine donors: synthesis of α-1,2-trans-2-bromo-2-deoxyglycopyranosyl bromides and fluorides, Application of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Synthesis (1993), 889-94, database is CAplus.

Addition of bromine to glycals using quaternary ammonium tribromides as bromine donors is realized with higher stereoselectivities (α-1,2-trans configurated products) compared to bromination with mol. bromine. The reaction is neither sensitive to the solvent nor to the nature of the protecting groups (acetyl, benzoyl, benzyl) of the glycals and very slightly affected by the orientation of the substituents of the different glycals. Some of the α-1,2-trans dibromo adducts have been isolated in 60-75% yields and transformed into the corresponding α-1,2-trans-2-bromo-2-deoxyglycopyranosyl fluorides.

Synthesis published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C6H12N2O, Application of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hammoud, Abdelhay published the artcileStereoselective synthesis of 1-acetoxy-7Z,11E-hexadecadiene or angoulure, the sex pheromone of the angoumois grain moth: Sitotrage cerealella Oliv, Formula: C7H13BrSi, the publication is Bulletin de la Societe Chimique de France (1978), 299-303, database is CAplus.

The title compound (I) was prepared by two methods: one involving a Wittig reaction and the other in which a Claisen-Johnson reaction was employed. Thus, (E)-BuCH:CH(CH₂)₃P⁺Ph₃ Br^– condensed with HCO(CH₂)₅CO₂Et to give (E,E)-BuCH:CHCH₂CH₂CH:CH(CH₂)₆CO₂Et, which was reduced (LiAlH₄) and O-acetylated to give I. The alkylation of (E)-HCCCH₂CH₂CH:CHBu by I(CH₂)₆OCH(OEt)Me yielded (E)-BuCH:CHCH₂CH₂CC(CH₂)₆OH, and O-acetylation and hydrogenation of the product gave I.

Bulletin de la Societe Chimique de France published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zeng, Xian-Liang published the artcileNucleophilic monofluoroalkylation with fluorinated phosphonium salt toward carbonyl and imine compounds, SDS of cas: 401-55-8, the publication is Journal of Fluorine Chemistry (2017), 17-23, database is CAplus.

A fluorinated substituent on the pos. phosphorus in phosphonium salt [Ph₃P⁺CF(Me)CO₂Et Br^–] was found to be able to act as a nucleophile to realize monofluoroalkylation of aldehydes, ketones and imines.

Journal of Fluorine Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C15H21BO3, SDS of cas: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Alexiou, Polyxeni published the artcileA Diverse Series of Substituted Benzenesulfonamides as Aldose Reductase Inhibitors with Antioxidant Activity: Design, Synthesis, and in Vitro Activity, Synthetic Route of 76283-09-5, the publication is Journal of Medicinal Chemistry (2010), 53(21), 7756-7766, database is CAplus and MEDLINE.

Based on bioisosteric principles, 2,6-difluorophenol and tetrazole, methylsulfonylamide, and isoxazolidin-3-one phenylsulfonamide derivatives were synthesized and tested in vitro in protocols primarily related to the long-term diabetic complications. Most of the compounds were found as aldose reductase inhibitors (ARIs) at IC₅₀ < 100 μM, while the introduction of the 4-bromo-2-fluorobenzyl group in a phenylsulfonamidodifluorophenol structure resulted in I, presenting a submicromolar inhibitory profile. However, the derivatives of tetrazole, methylsulfonylamine, and the (R)-enantiomer of isoxazolidin-3-one did not exhibit appreciable aldose reductase inhibitors (ARI) activity. The selectivity of the active ARIs is also discussed. Furthermore, the synthesized compounds exhibit potent antioxidant potential (homogeneous and heterogeneous systems).

Journal of Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Synthetic Route of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Belthle, Thomke published the artcileNanostructuring the Interior of Stimuli-Responsive Microgels by N-Vinylimidazoles Quaternized with Hydrophobic Alkyl Chains, COA of Formula: C12H25Br, the publication is Macromolecules (Washington, DC, United States) (2022), 55(3), 844-861, database is CAplus.

The functionality of stimuli-responsive microgels can be tailor-made by manipulating their internal nanostructure induced by the chem. composition and morphol. of the polymer network. Microgels with phase-separated domains on a nanoscopic length scale were synthesized by copolymerization of N-vinylcaprolactam (VCL) and amphiphilic-to-hydrophobic 1-vinyl-3-alkylimidazolium (VIM⁺C_nH_2n+1) bromides (Br^–) of different alkyl chain lengths (n = 12, 14, 16) as comonomers. These quaternized imidazoles provide dual functionality for immobilization of payload by electrostatic and hydrophobic interactions. The morphologies and properties of synthesized poly(VCL-co-VIM⁺C_nH_2n+1Br^–) microgels with 10 mol % comonomer were investigated systematically by ¹H and ¹³C high-resolution NMR spectroscopy and relaxometry. Chem. side-selective information about the monomers’ volume-phase transition temperatures, width of transition, and change in transition entropy was reported and correlated to the alkyl chain length of the VIM⁺C_nH_2n+1Br^– comonomer. ¹³C NMR spectroscopy reveals the existence of trans and gauche conformers of alkyl chains, which depends on the alkyl chain length and temperature Morphologies and dynamic contrasts of alkyl chain domains and VCL moieties of poly(VCL-co-VIM⁺C_nH_2n+1Br^–) microgels were investigated by ¹H transverse magnetization relaxation (T₂-relaxation). Finally, the microgels were successfully applied in the uptake of the hydrophobic dye Nile red, proving their ability to solubilize hydrophobic substances. In addition, the poly(VCL-co-VIM⁺C_nH_2n+1Br^–) microgels were utilized in electrostatic interactions, as well as simultaneous addition of hydrophobic and neg. charged payload as a proof of concept for dual functionality. This investigation will allow for a better understanding of the internal nanophase structure of complex poly(N-vinylcaprolactam) (PVCL)-based microgels comprising pH-independent pos. charges, as well as hydrophobic compartments, which have potential application as dual-functional delivery systems.

Macromolecules (Washington, DC, United States) published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, COA of Formula: C12H25Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary